6533b82ffe1ef96bd1295c4b

RESEARCH PRODUCT

Disturbed brain activation during a working memory task in drug-naive adult patients with ADHD.

Thomas GesierichGoran VucurevicAndreas KonradMichael HussPeter StoeterMartin BayerlFriederike VogelChristoph FehrThomas F. Dielentheis

subject

AdultMaleAdolescentCentral nervous systemPosterior parietal cortexYoung AdultNeuroimagingmental disordersmedicineAttention deficit hyperactivity disorderHumansMemory Disordersmedicine.diagnostic_testWorking memoryIllicit DrugsGeneral NeuroscienceBrainCognitionMiddle Agedmedicine.diseaseDrug-naïvemedicine.anatomical_structureMemory Short-TermAttention Deficit Disorder with HyperactivityFemalePsychologyFunctional magnetic resonance imagingNeurosciencemedicine.drug

description

Neuroimaging studies in attention-deficit/hyperactivity disorder (ADHD) have shown abnormalities in several brain areas including the frontostriatal circuitry and were mostly conducted in children and adolescents. We investigated 30 never-medicated adult ADHD patients (16 males) and 30 matched healthy control individuals. Functional magnetic resonance imaging was acquired during a working memory paradigm (n-back). Group activation maps and group differences of activation were calculated using voxel-based analyses. The generic activation pattern was more extended in the control group. In ADHD patients, significantly decreased activation was found in the right inferior parietal cortex. Disturbed parietal brain function may particularly contribute to inattention and working memory impairment in ADHD patients.

yearjournalcountryeditionlanguage
2010-04-21Neuroreport
10.1097/wnr.0b013e328338b9behttps://pubmed.ncbi.nlm.nih.gov/20224456