Search results for "Lieu"

L’irrespect sur les réseaux socionumériques

2018

Design of a Virtual Learning Environment for Students with Special Needs

2006

The European Social Fund-supported Portland Partnership project developed a computer-based virtual learning environment (VLE) to benefit students with cognitive and physical disabilities. This system provided students with access to a suite of software programs to teach them basic/essential skills needed for everyday life and to use information and communications technology (ICT). The VLE can be customized to meet individual students’ needs by selecting an input device, adjusting its setting, or choosing a symbol set to support on-screen text. The learning programs within the VLE required careful design to make them stimulating and beneficial to students who have diverse health conditions a…

The Extracellular δ-Domain is Essential for the Formation of CD81 Tetraspanin Webs

2014

AbstractCD81 is a ubiquitously expressed member of the tetraspanin family. It forms large molecular platforms, so-called tetraspanin webs that play physiological roles in a variety of cellular functions and are involved in viral and parasite infections. We have investigated which part of the CD81 molecule is required for the formation of domains in the cell membranes of T-cells and hepatocytes. Surprisingly, we find that large CD81 platforms assemble via the short extracellular δ-domain, independent from a strong primary partner binding and from weak interactions mediated by palmitoylation. The δ-domain is also essential for the platforms to function during viral entry. We propose that, ins…

Rapid and sensitive detection of metapneumovirus in clinical specimens by indirect fluorescence assay using a monoclonal antibody.

2008

Human metapneumovirus, with two known genotypes named A and B, is associated with mild respiratory symptoms to severe LRTI in children, high-risk adults and the elderly. Rapid and reliable methods of hMPV detection in clinical samples are essential to implement appropriate care, to better understand the pathology of hMPV and to determine its epidemiology. Respiratory samples from 1,386 patients collected during 2 consecutive years were screened for hMPV using indirect immunofluorescence (IFA) assay with a monoclonal antibody. Forty-three patients tested positive for hMPV by the IFA method. In parallel, the samples were examined with RT-PCR on the F gene. Of these, 41 specimens were RT-PCR p…

Fenêtres sur couples : trois nouvelles de Sean O'Faolain

2003

In several short stories, Sean O'Faolain ponders over the complexity of love relationships and tries to unveil some of the unconscious motivations underlying them. This essay focuses on three of these short stories, namely "There's a Birdie in the Cage", "Discord" and "An Inside Outside Complex", and shows how, in each of them, the fissures or cracks in love relationships are figuratively represented by an isotopy of windows, the various qualities of which are artfully exploited by O'Faolain (the window as partition between contiguous spaces, as transparent filter, as surface or frame). The position of characters with regard to windows (their framing) and their relations to windows (how the…

Du territoire géographique au territoire économique : la situation de la viticulture

2011

Through time and space, the construction of the wine territories reveals them as subjects of economic issues. The analysis of these economic issues mobilizes traditional concepts (theory of comparative advantages) and more moderns (new economic geography). Thus, we progress gradually from the geographical territory with numerous dimensions (subsoil, soil, vegetation…) to the concept of economic territory of which the use by the wine growing refers to the traditional factors of structuring and the use of space (ground, population, financing, nature, …). Considering the use of these various factors within a region, a country or / and between several countries requires: (1) to consider the int…

Study of vocalists' use of emotions in performance preparation

2015

Musicians and educators understand the importance of expressivity in vocal performance. Despite the acceptance of expressivity as a crucial element in musical performance, educators have reported addressing it only cursorily or not addressing it at all when preparing for a performance. For these reasons, this research has focused on techniques used by trained musicians when preparing a performance, to be adapted and applied for use by teachers with their large vocal ensembles. Participants in this study were enrolled in vocal / operatic performance programs at universities in the United States, Ireland, Finland, and Hong Kong. Their progress was tracked throughout the semester by three ques…

Réduction de la place de la voiture à Lyon: l'acceptation sociale ne fait pas tout

2015

International audience

Highly sensitive olfactory biosensors for the detection of volatile organic compounds by surface plasmon resonance imaging

2018

International audience; Nowadays, monitoring of volatile organic compounds (VOCs) is very important in various domains. In this work, we aimed to develop sensitive olfactory biosensors using odorant binding proteins (OBPs) as sensing materials. Three rat OBP3 derivatives with customized binding properties were designed and immobilized on the same chip for the detection of VOCs in solution by surface plasmon resonance imaging (SPRi). We demonstrated that the proteins kept their binding properties after the immobilization under optimized conditions. The obtained olfactory biosensors exhibited very low limits of detection in both concentration (200pM of beta-ionone) and in molecular weight of …

Retour sur une recherche européenne sur le volontariat des aînés et réflexions sur les particularismes français

2016

International audience