Search results for "Ligo"
showing 10 items of 1427 documents
El demonio social en la Constitución / 3
2004
Este artículo forma un bloque junto a "Ambiciones de un europeísta (1)" (El País, 2 de octubre de 2004); "Matria Europa, 2" (El País, 16 de octubre de 2004) y "Prisas intergubernamentales / 4" (El País, 30 de obtubre de 2004).
Introduction and Technical Survey: Protein Aggregation and Fibrillogenesis
2012
In this chapter we provided the overall background to the subject of protein aggregation and fibrillogenesis in amyloidogenesis, with introduction and brief discussion of the various topics that are included with the coming chapters. The division of the book into basic science and clinical science sections enables correlation of the topics to be made. The many proteins and peptides that have currently been found to undergo fibrillogenesis are tabulated. A broad technical survey is made, to indicate the vast array of techniques currently available to study aspects of protein oligomerization, aggregation and fibrillogenesis. These are split into three groups and tabulated, as the microscopica…
A methodology to assess the intrinsic discriminative ability of a distance function and its interplay with clustering algorithms for microarray data …
2013
Abstract Background Clustering is one of the most well known activities in scientific investigation and the object of research in many disciplines, ranging from statistics to computer science. Following Handl et al., it can be summarized as a three step process: (1) choice of a distance function; (2) choice of a clustering algorithm; (3) choice of a validation method. Although such a purist approach to clustering is hardly seen in many areas of science, genomic data require that level of attention, if inferences made from cluster analysis have to be of some relevance to biomedical research. Results A procedure is proposed for the assessment of the discriminative ability of a distance functi…
«Nomina sunt consequentia rerum» anche nella controversia sul danno al concepito per malformazioni genetiche. Il punto dopo le Sezioni unite, 22 dice…
2016
La nota commenta la sentenza delle Sezioni unite del 22 dicembre 2015, n. 25767 sulla controversia questione del danno c.d. da nascita indesiderata e del c.d. danno da vita indesiderata. L'autore sottopone ad analisi la sentenza alla luce dei precedenti della medesima corte, soffermandosi sul problema della distribuzione dei temi di prova in sede di giudizio di responsabilità per violazione da parte del medico dell'obbligo di informare la paziente, sul dilemma dello status giuridico del concepito e infine sul tema delicatissimo della sussistenza o meno di un danno da malformazioni genetiche, indicato anche come c.d. danno da vita indesiderata.
Linear Organo-Soluble Poly(p-benzamide)
2009
Organo-soluble, shape-persistent oligo- and poly(p-benzamide)s were synthesized and characterized. A triethylene glycol (TEG) substituent was introduced to the p-aminobenzoic acid monomer structure as a solubilizing side chain giving 4-amino-2-triethylene glycol benzoic acid. This new monomer was polymerized by the facile polycondensation of the corresponding acid halide derivative of the amine hydrochloric salt. Additionally, a well-defined heptamer was prepared from this monomer on a peptide synthesizer as a model compound. The TEG-substituted oligomers and polymers exhibited good solubility yet high aggregation tendency in common polar and nonpolar organic solvents. The solution self-org…
Farsighted R&D networks
2014
We analyze the formation of bilateral R&D collaborations in an oligopoly when each firm benefits from the research done by other firms it is connected to. In contrast to myopic stability, farsighted stability leads to R&D networks consisting of two minimally connected components, with the largest one comprising three-quarters of firms.
MicroRNA-Based Therapeutic Perspectives in Myotonic Dystrophy
2019
Myotonic dystrophy involves two types of chronically debilitating rare neuromuscular diseases: type 1 (DM1) and type 2 (DM2). Both share similarities in molecular cause, clinical signs, and symptoms with DM2 patients usually displaying milder phenotypes. It is well documented that key clinical symptoms in DM are associated with a strong mis-regulation of RNA metabolism observed in patient’s cells. This mis-regulation is triggered by two leading DM-linked events: the sequestration of Muscleblind-like proteins (MBNL) and the mis-regulation of the CUGBP RNA-Binding Protein Elav-Like Family Member 1 (CELF1) that cause significant alterations to their important functions in RNA processing. It ha…
LA CONTRATTAZIONE COLLETTIVA NEGLI STATI UNITI DAL WAGNER ACT AI NOSTRI GIORNI
2016
LA CONTRATTAZIONE COLLETTIVA NEGLI STATI UNITI. DAL WAGNER ACT AI NOSTRI GIORNI. — Riassunto. Il presente lavoro analizza la legislazione statunitense in materia di contrattazione collettiva sin dall’emanazione del Wagner Act nel 1935. Al riguardo, vengono discusse le regole per il riconoscimento dei sindacati nei luoghi di lavoro e per la stipula degli accordi collettivi (principio di maggioranza e rappresentanza esclusiva, obbligo di negoziare secondo buona fede) e per la gestione del conflitto industriale (arbitrato e clausola di tregua): sulla scorta di un approccio storico-critico e dei leading case giurisprudenzialil’articolosottolineailcarattereprettamenteaziendaleeprivatisticodellere…