Search results for "Limoge"

SOLTI-1503 PROMETEO TRIAL: combination of talimogene laherparepvec with atezolizumab in early breast cancer

2020

New treatment strategies such as immune checkpoint inhibitors and oncolytic viruses are opening new possibilities in cancer therapy. Preliminary results in melanoma and other tumors showed that the combination of talimogene laherparepvec with an anti-PD-1/PD-L1 or anti-CTLA4 has greater efficacy than either therapy alone, without additional safety concerns beyond those expected for each agent. The presence of residual cancer after neoadjuvant chemotherapy in early breast cancer patients is an unmet medical need. SOLTI-1503 PROMETEO is a window of opportunity trial, which evaluates the combination of talimogene laherparepvec in combination with atezolizumab in women with operable HER2-negati…

Oncolytic Virotherapy as Emerging Immunotherapeutic Modality: Potential of Parvovirus H-1

2014

Human tumors develop multiple strategies to evade recognition and efficient suppression by the immune system. Therefore, a variety of immunotherapeutic strategies have been developed to reactivate and reorganize the human immune system. The recent development of new antibodies against immune check points may help to overcome the immune silencing induced by human tumors. Some of these antibodies have already been approved for treatment of various solid tumor entities. Interestingly, targeting antibodies may be combined with standard chemotherapy or radiation protocols. Furthermore, recent evidence indicates that intratumoral (it) or intravenous (iv) injections of replicative oncolytic viruse…

Abstract OT-13-06: Solti-1503 PROMETEO: Talimogene laherparepvec (T-VEC) + atezolizumab combination in early breast cancer

2021

Abstract Background Residual disease (RD) after standard neoadjuvant chemotherapy (NAC) is composed of drug resistant cells and associates with increased risk of relapse, especially in triple negative, HER2-positive, and highly proliferative Luminal tumors. Immunotherapy combinations can induce of specific anti-tumor immune responses, such as those mediated by T-cells, and which might represent an additional strategy for the control or elimination of residual tumor cells. Preliminary results in melanoma showed that the combination of T-VEC with an anti PD-L1 or anti CTLA4 has greater efficacy than either therapy alone, without additional safety concerns beyond those expected for each agent.…

Un problema di critica testuale nel 'Versus Sancte Marie' limosino (BnF lat. 1139, c. 49r-50r)

2017

I quattro componimenti interamente o parzialmente in volgare occitanico (limosino settentrionale) contenuti all’interno della parte più antica (sec. XI ex.) del cosiddetto ‘tropario’ di San Marziale di Limoges (Parigi, BnF, lat. 1139) sono stati studiati soprattutto per la loro rilevanza linguistica e culturale. Questo contributo si focalizza sul testo, relativamente poco studiato, del 'Versus Sancte Marie' (incipit "O Maria, Deu maire"), nel quale persiste un errore finora non notato e sanabile ricorrendo al principio ecdotico di «contesto remoto» (Au. Roncaglia).

Crypte de l’abbaye Saint-Martial - Limoges, Haute-Vienne (87). Etude des liants de maçonnerie

2013

Eglise abbatiale du Sauveur - Limoges, Haute-Vienne (87) - Etude des liants de maçonnerie

2016

San Luigi: reliquie e reliquiari tra Terrasanta, Francia e Sicilia

2017

Lo studio prende in esame i destini delle reliquie dei visceri del re santo, tra Terrasanta, Sicilia, Tunisi, Francia, dal XIII al XX secolo, e dei loro preziosi contenitori; fra gli oggetti più interessanti figura un'inedita arqueta amatoria catalana in legno e pastiglia dorata con parti metalliche, già policromata, della prima metà del XV secolo, giunta a Monreale verosimilmente tramite un arcivescovo iberico; si passano quindi in rassegna i noti reliquiari secondo la tradizione donati da Filippo IV di Francia alla Chiesa monrealese (della Sacra Spina, secc. XIII-XVII; del Santo Sangue di Cristo, del latte e dei capelli della Madonna, della manna del deserto, ultimo quarto del XIII secolo…