Search results for "Linea"

Competencias del Estado sobre los espacios marinos y sobre el espacio aéreo

2020

Competencias sobre los espacios marinos bajo la jurisdicción del Estado ribereño y fuera de la jurisdicción del Estado ribereño

A novel linear friction welding based approach for sheet-bulk joining

2019

In the last decades, the development of new, flexible manufacturing processes caused the increase of the demands for highly customized complex functional parts in many industrial fields. The peculiar design of these components often overcome conventional sheet metal and bulk metal forming processes capabilities. In order to face this issue, new hybrid techniques, capable of exploit key advantages of different processes, have to be developed. In this paper, a novel approach based on the Linear Friction Welding process is proposed to obtain sheet-bulk joints. The feasibility of the technique on high specific strength alloys is investigated through an experimental campaign.In the last decades,…

Distinctive amino acid residue periodicities in terminal sequences of type III and type I secreted proteins from proteobacteria

2007

AbstractThe Fourier transform (FT) method was applied to specify the distribution of 14 predefined groups of amino acids (64 residues) at both termini of annotated type III and type I secreted proteins from proteobacteria. Type I proteins displayed a higher occurrence of significant periodicities at both C-and N-termini, indicating potent features to discriminate between secretion types, particularly by the use of variables selected from the full periodicity profiles at 19 orders of FT. The Fishers linear discriminant analysis, together with the stepwise selection of variables throughout equal pairs of combinations for all predefined groups of residues, revealed the C-terminal harmonics of …

Unveiling the Different Reactivity of Bent and Linear Three-Atom-Components Participating in [3 + 2] Cycloaddition Reactions

2021

The reactivity of a series of pairs of bent and linear three-atom-component (B-TACs and L-TACs) participating in [3 + 2] cycloaddition (32CA) reactions towards ethylene and electrophilic dicyanoethylene (DCE) have been studied within the Molecular Electron Density Theory. While the pseudodiradical structure of B-TACs changes to that of pseudoradical or carbenoid L-TACs upon dehydrogenation, zwitterionic B-TACs remain unchanged. Conceptual Density Functional Theory (CDFT) indices characterize five of the nine TACs as strong nucleophiles participating in polar reactions towards electrophilic ethylenes. The activation energies of the 32CA reactions with electrophilic DCE range from 0.5 to 22.0…

Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity

2017

Strategies for promoting neural regeneration are hindered by the difficulty of manipulating desired neural fates in the brain without complex genetic methods. The subventricular zone (SVZ) is the largest germinal zone of the forebrain and is responsible for the lifelong generation of interneuron subtypes and oligodendrocytes. Here, we have performed a bioinformatics analysis of the transcriptome of dorsal and lateral SVZ in early postnatal mice, including neural stem cells (NSCs) and their immediate progenies, which generate distinct neural lineages. We identified multiple signaling pathways that trigger distinct downstream transcriptional networks to regulate the diversity of neural cells …

Context-dependent Pax-5 repression of a PU.1/NF-κB regulated reporter gene in B lineage cells

2001

Enhancers located in the 3' end of the locus in part regulate immunoglobulin heavy chain (IgH) gene expression. One of these enhancers, HS 1,2, is developmentally regulated by DNA binding proteins like NF-kappaB, Pax-5 and the protein complex NF-alphaP in B lineage cells. Here we report that NF-alphaP is the ets protein PU.1. A glutathione-S-transferase (GST)-pulldown assay demonstrated that PU.1 can physically interact with NF-kappaB in solution. Experiments in COS cells showed that PU.1 and NF-kappaB (p50/c-Rel) can activate transcription of an enhancer linked reporter gene. The paired domain protein Pax-5 has previously been shown to repress enhancer-dependent transcription. Additional c…

The pattern of neuroblast formation, mitotic domains and proneural gene expression during early brain development in Drosophila.

2003

In the Drosophila embryo, studies on CNS development have so far mainly focused on the relatively simply structured ventral nerve cord. In the trunk, proneural genes become expressed in small cell clusters at specific positions of the ventral neuroectoderm. A lateral inhibition process mediated by the neurogenic genes ensures that only one cell within each proneural cluster delaminates as a neural stem cell (neuroblast). Thus, a fixed number of neuroblasts is formed, according to a stereotypical spatiotemporal and segmentally repeated pattern, each subsequently generating a specific cell lineage. Owing to higher complexity and hidden segmental organisation, the mechanisms underlying the dev…

Parametri tecnologici allo stato plastico e dopo cottura

2011

Aperiodicity in finitely generated bi-ideals and bounded bi-ideals

2014

Disertācijā pētīts aperiodiskums divu vienpusēji bezgalīgu vārdu klašu – galīgi ģenerētu biideālu un ierobežotu bi-ideālu – kontekstā. Gan galīgi ģenerētus bi-ideālus, gan ierobežotus biideālus ir ērti uzdot, izmantojot bāzes virkni. Ierobežotu bi-ideālu gadījumā tiek nofiksēta galīga vārdu kopa, no kuras tiek uzģenerēta bāzes virkne. Savukārt galīgi ģenerētu bi-ideālu gadījumā bāzes virkne ir periodiska, līdz ar to var uzskatīt, ka ir dota galīga bāze. Efektīvā ģenerēšana un zināmie aperiodiskuma nosacījumi kalpo par motivāciju apskatīt galīgi ģenerētu bi-ideālu potenciālo pielietojumu kriptogrāfijā – aperiodisku gadījuma skaitļu ģenerēšanā. Savukārt, ierobežoti bi-ideāli ir galīgi ģenerēt…

Nonlinear optical properties of diaromatic stilbene, butadiene and thiophene derivatives

2021

Series of highly polar stilbene (1a–e), diphenylbutadiene (2a–c) and phenylethenylthiophene (3a–c) derivatives were prepared via Horner–Wadsworth–Emmons method with a view to produce new and efficient materials for second harmonic generation (SHG) in the solid-state. The single-crystal X-ray structures of compounds 1–3 reveal extensive polymorphism and a peculiar photodimerization of the 2-chloro-3,4-dimethoxy-4′-nitrostilbene derivative 1a to afford two polymorphs of tetra-aryl cyclobutane 4. The stilbene congeners 2-chloro-3,4-dimethoxy-4′-nitrostilbene (1a·non-centro), 5-bromo-2-hydroxy-3-nitro-4′-nitrostilbene (1b) and 4-dimethylamino-4′-nitrostilbene (1e), as well as 4′-fluoro-4′′-nitr…