Search results for "Lip"

Experiencing life together : a cooperative CLIL course on social psychology

2013

Tämä pro gradu-tutkielmana laadittu materiaalipaketti yhdistää kielen ja sisällön oppimisen content and language integrated learning- eli CLIL-menetelmän avulla. CLIL:n keskeinen ajatus on, että opiskelija oppii kieltä toisen oppiaineen kautta. Autenttisten materiaalien käyttö sekä opiskelijoiden keskinäinen yhteistyö takaavat kielen implisiittisen oppimisen. Lisäksi opettajan tulisi kiinnittää opiskelijoiden huomio myös kielenoppimiseen explisiittisesti. Tukemaan CLIL-menetelmää valittiin yhteistoiminnallinen oppiminen. Se on tarkoin strukturoitu opetusmenetelmä, jossa opiskelijat työskentelevät yhdessä yhteisen tavoitteen saavuttamiseksi. Yhteistoiminnallisia tehtävätyyppejä ja –rakenteit…

Disagreement, Points of View, and Truth-Relativism

2022

AbstractTruth-relativism is the claim that the truth of statements is dependent on the context in which they are made. In this article, truth-relativism is considered as a way to explain disagreements. Viewpoint relativism, a recent version of truth-relativism, is introduced as a useful framework to analyse how truth-relativism approaches disagreements. Viewpoint relativism is based on contextual semantics and the logic of viewpoint, which is a two-dimensional modal logic. In viewpoint relativism, the central concept is a point of view in relation to which truth claims are evaluated. Viewpoint relativism is compared to the truth-relativism of Peter Lasersohn and John MacFarlane. Finally, tr…

Kulttuurin leikillistyminen ja pelillistyminen

2022

Yleisopetukseen integroitujen aistivammaisten oppilaiden mielipiteet ja viihtyvyys koululiikunnassa

1999

CODA-lasten asema kielipoliittisissa ja kielikoulutuspoliittisissa teksteissä vuosina 1993-2010

2013

Lehtinen, Joonas. CODA-lasten asema kielipoliittisissa ja kielikoulutuspoliittisissa teksteissä vuosina 1993–2010. Kasvatustieteen pro gradu -työ. Jyväskylän yliposton kasvatustieteen laitos, 2013. 70 sivua. Kielipoliittisilla päätöksillä on vaikutusta lasten ja nuorten kieli identiteetin kehittymiseen. Varsinkin vähemmistökielten käyttäjien mahdollisuus käyttää omaa äidinkieltään ei ole kovin hyvät. Tutkimuksen tarkoituksena on tuoda julki niitä keinoja, joilla CODA-lapsia asemoidaan kieli- ja kielikoulutuspoliittisissa teksteissä. Tutkimuksessa tarkastelen myös, miten CODA-lasten asema on muuttunut kieli- ja kielikoulutuspoliittisissa teksteissä vuosien 1993–2010 välisenä aikana. Aihetta …

Occlusion-derived baculovirus: interaction with human cells and evaluation of the envelope protein P74 as a surface display platform.

2008

To develop complementary baculovirus-based tools for gene delivery and display technologies, the interaction of occlusion-derived baculovirus (ODV) with human cells, and the functionality of the P74 ODV envelope protein for display of the IgG-binding Z domains (ZZP74) were evaluated. The cellular binding of ODV was concentration-dependent and saturable. Only minority of the bound virions were internalized at both 37 and 4 degrees C, suggesting usage of direct membrane fusion as the entry mode. The intracellular transport of ODV was confined in vesicular structures peripheral to the plasma membrane, impeding subsequent nuclear entry and transgene expression. Transduction of ODV was not rescu…

Transfection of lipoma cells with papilloma bovine virus subgenomic fragment.

1991

Abstract Lipoma cells with consistent chromosomal aberration have been transfected with plasmids carrying papilloma bovine virus subgenomic fragment (PBV 69). The succesful transformation of the cells was ascerted on the changed growth pattern of the cells in liquid medium, colony formation in soft agar and modified cell appearrance in electron microscopy; transfection with PBV 69 has not been, however, sufficient to immortalize lipoma cells.

Binding and internalization of human papillomavirus type 33 virus-like particles by eukaryotic cells

1995

Infection of cells by human papillomaviruses (HPVs) associated with malignant genital lesions has not been studied because of the lack of an in vitro system and the unavailability of virions. We have now used virus-like particles (VLPs) of HPV type 33 to analyze the initial events in the interaction of the HPV capsid with cell lines. Binding of VLPs to HeLa cells was observed in biochemical assays and by immunofluorescence. VLP binding was inhibited by antisera raised against VLPs but not by monoclonal antibodies recognizing either L1 or L2 epitopes accessible on VLPs. Under saturating conditions, approximately 2 x 10(4) VLPs were bound per cell, with a dissociation constant of about 100 pM…

Human Papillomavirus Types 16, 18, and 31 Share Similar Endocytic Requirements for Entry

2013

ABSTRACT Human papillomavirus type 18 (HPV18), one of the HPVs with malignant potential, enters cells by an unknown endocytic mechanism. The key cellular requirements for HPV18 endocytosis were tested in comparison to those for HPV16 and -31 endocytoses. HPV18 (like HPV16 and -31) entry was independent of clathrin, caveolin, dynamin, and lipid rafts but required actin polymerization and tetraspanin CD151, and the viruses were routed to the same LAMP-1-positive compartment. Hence, the viruses shared similar cellular requirements for endocytic entry.

The closest relatives of icosahedral viruses of thermophilic bacteria are among viruses and plasmids of the halophilic archaea.

2009

We have sequenced the genome and identified the structural proteins and lipids of the novel membranecontaining, icosahedral virus P23-77 of Thermus thermophilus. P23-77 has an 17-kb circular double-stranded DNA genome, which was annotated to contain 37 putative genes. Virions were subjected to dissociation analysis, and five protein species were shown to associate with the internal viral membrane, while three were constituents of the protein capsid. Analysis of the bacteriophage genome revealed it to be evolutionarily related to another Thermus phage (IN93), archaeal Halobacterium plasmid (pHH205), a genetic element integrated into Haloarcula genome (designated here as IHP for integrated Ha…