Search results for "Lipid-peroxidation"

showing 3 items of 3 documents

The effects of alpha-cypermethrin exposure on biochemical and redox parameters in pregnant rats and their newborns

2016

IF 2.388; International audience; Pyrethroid insecticides are extensively used in agriculture and in household activities. During pregnancy, they might affect maternal metabolic status and there after fetal development. In this work, we studied metabolic and redox effects of low dose alpha-cypermethrin exposure in pregnant rats and their offspring. The diet containing alpha cypermethrin at 0.02 mg/kg/day was consumed during the entire gestation. Plasma biochemical parameters as well as liver lipid and oxidative stress markers were determined. Our results showed that alpha-cypermethrin induced an increase in body weight and in plasma glucose and lipid levels, as well as in plasma aspartate a…

Blood Glucose0301 basic medicineLipid-PeroxidationInsecticidesHealth Toxicology and Mutagenesismedicine.disease_causeCypermethrinchemistry.chemical_compoundMice0302 clinical medicinePregnancyMalondialdehydePyrethrinsMaternal-Fetal Exchange[ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]Alpha-cypermethrinAlanine TransaminaseGeneral Medicine030224 pathologyGlutathioneLipidsMitochondriaLiverPrenatal Exposure Delayed EffectsGestationAlkaline phosphataseFemaleChlorpyrifosOxidation-Reductionmedicine.medical_specialtyOffspringBlood sugarBiology03 medical and health sciencesProtective RoleOffspringMetabolic DiseasesInternal medicinemedicineNeurotoxicityAnimalsAspartate AminotransferasesRats WistarPesticides[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry Molecular BiologyPregnancyFetusBody Weightmedicine.diseaseRatsOxidative Stress030104 developmental biologyEndocrinologyMetabolismAnimals NewbornchemistryRatAgronomy and Crop ScienceDeltamethrinFenvalerateOxidative stress
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Melatonin protects rats from radiotherapy-induced small intestine toxicity

2017

Radiotherapy-induced gut toxicity is among the most prevalent dose-limiting toxicities following radiotherapy. Prevention of radiation enteropathy requires protection of the small intestine. However, despite the prevalence and burden of this pathology, there are currently no effective treatments for radiotherapy-induced gut toxicity, and this pathology remains unclear. The present study aimed to investigate the changes induced in the rat small intestine after external irradiation of the tongue, and to explore the potential radio-protective effects of melatonin gel. Male Wistar rats were subjected to irradiation of their tongues with an X-Ray YXLON Y.Tu 320-D03 irradiator, receiving a dose o…

Male0301 basic medicineCancer TreatmentDrug Evaluation Preclinicallcsh:MedicineExpressionApoptosisToxicologyPathology and Laboratory Medicinemedicine.disease_causeBiochemistryOxidative Phosphorylation0302 clinical medicineIntestinal mucosaGastrointestinal tractIntestine SmallMedicine and Health SciencesRadiation-injuryIntestinal Mucosalcsh:ScienceEnergy-Producing OrganellesMelatoninCancerMultidisciplinaryNF-kappa BInflammasomeLipid-peroxidationGlutathioneMitochondriaRadiation therapyRadiation Injuries Experimentalmedicine.anatomical_structureOncology030220 oncology & carcinogenesisCancer treatmentToxicityInflammasome activationSmall IntestineExperimental pathologyAnatomyCellular Structures and OrganellesResearch Articlemedicine.drugClinical OncologyMucositismedicine.medical_specialtyRadiation TherapyRadiation-Protective AgentsBioenergeticsBiologyRadiation enteropathyMelatonin03 medical and health sciencesTongueInternal medicineSepsisNLR Family Pyrin Domain-Containing 3 ProteinmedicineAnimalsRats WistarMouthToxicitylcsh:RBiology and Life SciencesCell BiologySmall intestinemedicine.diseaseHormonesSmall intestinePathobiologyGastrointestinal TractOxidative Stress030104 developmental biologyEndocrinologylcsh:QClinical MedicineDigestive SystemGelsOxidative stress
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7-Nitroindazole protects striatal neurons against MPP+ -induced degeneration.

2006

The neuropathological hallmark of Parkinson's disease (PD) is the selective degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNc). In this study, using a microdialysis technique, we investigated whether an inhibitor of neuronal nitric oxide synthase (nNOS), 7-nitrindazole (7-NI), could protect against DAergic neuronal damage induced by in vivo infusion of 1-methyl-4-phenylpiridinium iodide (MPP+) in freely moving rats. Experiments were performed over 2 days in three groups of rats: (a) nonlesioned, (b) MPP+-lesioned, and (c) 7-NI pretreated MPP+-lesioned rats. On day 1, control rats were perfused with an artificial CSF, while 1 mM MPP+ was infused into t…

PARKINSONS-DISEASERAT STRIATUMMONOAMINE-OXIDASENITRIC-OXIDE SYNTHASEBRAINNEURODEGENERATIVE DISEASESSODIUM-SALICYLATEMPTP NEUROTOXICITYTRANSPORTER ACTIVITYLIPID-PEROXIDATION
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