Search results for "Lobular"
showing 10 items of 77 documents
Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly. Corrigendum
2020
The article by Casino et al. [IUCrJ (2018). 5, 765–779] is corrected.
The spin and orbit of the newly discovered pulsar IGR J17480-2446
2011
We present an analysis of the spin and orbital properties of the newly discovered accreting pulsar IGR J17480-2446, located in the globular cluster Terzan 5. Considering the pulses detected by the Rossi X-ray Timing Explorer at a period of 90.539645(2) ms, we derive a solution for the 21.27454(8) hr binary system. The binary mass function is estimated to be 0.021275(5) Msun, indicating a companion star with a mass larger than 0.4 Msun. The X-ray pulsar spins up while accreting at a rate of between 1.2 and 1.7E-12 Hz/s, in agreement with the accretion of disc matter angular momentum given the observed luminosity. We also report the detection of pulsations at the spin period of the source dur…
Underestimation of atypical lobular hyperplasia and lobular carcinoma in situ at stereotaxic 11-gauge vacuum-assisted breast biopsy
2013
The aims of this study are to determine the frequency of diagnosis of atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS) at stereotaxic-guided 11-gauge vacuum-assisted breast biopsy (VABB) and to assess the rate of underestimation of these at subsequent surgical excision and follow-up. Moreover, we aimed to define clinical, radiological and histological features of nonpalpable lesions in core biopsies that predict the lesion upgrade. Retrospective review of 11-gauge VABB was performed to identify the underestimation rate of nonpalpable lesions diagnosed as ALH or LCIS at VABB. Thirteen cases of ALH and 36 cases of LCIS were sent to surgery, 29 cases of ALH and 14 cases…
“Hard” Sphere Behavior of “Soft”, Globular-like, Hyperbranched Polyglycerols – Extensive Molecular Hydrodynamic and Light Scattering Studies
2020
Whether or not hyperbranched polymers behave like quasi “hard spheres” in solution is the subject of numerous fundamental discussions, also motivated by research on the perfectly branched dendrimer...
Anodic Electro Deposition of CeO2 and Co-Doped CeO2 Thin Films
2013
CeO2 and Co containing CeO2 thin films were deposited on indium tin oxide and stainless steel by anodic electrodeposition. Scanning electron microscopy showed that the films are flat and show globular morphology and cracks resulting from volume shrinking. According to XRD and Raman Spectroscopy pure ceria layers are crystalline, while the presence of Co induces the formation of amorphous films. The good adhesion and the compactness allowed the photoelectrochemical characterization of the films. A band gap value of 2.9 eV was estimated for CeO2, while slightly higher values (̃3.0 eV) were estimated for Co containing films. A mechanism for ceria anodic electrodeposition is proposed and discus…
On the nature of a shell of young stars in the outskirts of the Small Magellanic Cloud
2019
Understanding the evolutionary history of the Magellanic Clouds requires an in-depth exploration and characterization of the stellar content in their outer regions, which ultimately are key to tracing the epochs and nature of past interactions. We present new deep images of a shell-like over-density of stars in the outskirts of the Small Magellanic Cloud (SMC). The shell, also detected in photographic plates dating back to the fifties, is located at ~1.9 degr from the center of the SMC in the north-east direction.The structure and stellar content of this feature were studied with multi-band, optical data from the Survey of the MAgellanic Stellar History (SMASH) carried out with the Dark Ene…
Self-assembling of poly(aspartic acid) with bovine serum albumin in aqueous solutions
2016
Abstract Macromolecular co-assemblies built up in aqueous solutions, by using a linear polypeptide, poly(aspartic acid) (PAS), and a globular protein, bovine serum albumin (BSA), have been studied. The main interest was to identify the optimum conditions for an interpenetrated complex formation in order to design materials suitable for biomedical applications, such as drug delivery systems. BSA surface possesses several amino- and carboxylic groups available for covalent modification, and/or bioactive substances attachment. In the present study, mixtures between PAS and BSA were investigated at 37 °C in dilute aqueous solution by viscometry, dynamic light scattering and zeta potential deter…
Small-angle X-ray scattering reveals compact domain-domain interactions in the N-terminal region of filamin C
2014
Filamins are multi-domain, actin cross-linking, and scaffolding proteins. In addition to the actin cross-linking function, filamins have a role in mechanosensor signaling. The mechanosensor function is mediated by domain-domain interaction in the C-terminal region of filamins. Recently, we have shown that there is a three-domain interaction module in the Nterminal region of filamins, where the neighboring domains stabilize the structure of the middle domain and thereby regulate its interaction with ligands. In this study, we have used small-angle X-ray scattering as a tool to screen for potential domain-domain interactions in the N-terminal region. We found evidence of four domain-domain in…
Seaweed fails to prevent ocean acidification impact on foraminifera along a shallow-water CO2 gradient
2015
Ocean acidification causes biodiversity loss, alters ecosystems, and may impact food security, as shells of small organisms dissolve easily in corrosive waters. There is a suggestion that photosynthetic organisms could mitigate ocean acidification on a local scale, through seagrass protection or seaweed cultivation, as net ecosystem organic production raises the saturation state of calcium carbonate making seawater less corrosive. Here, we used a natural gradient in calcium carbonate saturation, caused by shallow-water CO2 seeps in the Mediterranean Sea, to assess whether seaweed that is resistant to acidification (Padina pavonica) could prevent adverse effects of acidification on epiphytic…
“Weekly docetaxel and gemcitabine as first line treatment for metastatic breast cancer: results of a multicenter phase II study”
2004
<i>Objectives:</i> We conducted a multicenter phase II study to evaluate the clinical efficacy, toxicity, and dose intensity of a new weekly schedule of docetaxel and gemcitabine as first-line treatment of metastatic breast cancer patients. <i>Methods:</i> We enrolled 58 patients, 52% of whom had received a previous anthracycline-containing chemotherapy. The treatment schedule was: docetaxel 35 mg/m<sup>2</sup> and gemcitabine 800 mg/m<sup>2</sup> i.v. on days 1, 8, 15 every 28 days. <i>Results:</i> All patients were assessable for toxicity and 56 for efficacy. Overall response rate was 64.3% with 16.1% of complete responses and 48…