Search results for "Localization"
showing 10 items of 443 documents
La diffusion des NTIC au sein du réseau urbain français et le rôle des acteurs publics
2001
The study deals with the ways in which the general public and the government make use of new information and communication technologies. We analyze the physical locations of Internet sites with “fr” as their domain names. The data were provided by the French NIC center (AFNIC). Using this sample (a quarter of all French sites), we find a rather even distribution of French sites in the Paris area plus the other main French cities, and the remainder of France. In addition, we try to enumerate the initiatives of the public actors responsible for the regional planning of the new information and communication technologies. Firstly, we clarify the economic and legal framework in which public acto…
A Tale of Two Re-branded Cities: Riga, Latvia and Aarhus, Denmark
2016
Abstract This study shows how Riga and Arhus identified, formulated and communicated city re-branding. Our analysis concentrates on resident responses to city re-branding and how such responses could force the municipalities to withdraw their re-branding. A city loses its identity if it is globalized. In the Riga and Aarhus cases, the municipalities tried to find a global voice, which contradicted local traditions; and in both cases, the redefinition of city image took place top-down and not bottom-up. The two cases may not prove to be a golden rule, but should be a warning against rash city re-branding decisions made by municipalities.
Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells
2013
AbstractPluripotency is maintained by both known and unknown transcriptional regulatory networks. In the present study, we have identified Zfp819, a KRAB-zinc finger protein, as a novel pluripotency-related factor and characterized its role in pluripotent stem cells. We show that Zfp819 is expressed highly in various types of pluripotent stem cells but not in their differentiated counterparts. We identified the presence of non-canonical nuclear localization signals in particular zinc finger motifs and identified them as responsible for the nuclear localization of Zfp819. Analysis of the Zfp819 promoter region revealed the presence of a transcriptionally active chromatin signature. Moreover,…
MUC1-CT mediates corticosteroid responses in COPD
2016
Background: Corticosteroid resistance is an acquired condition in chronic obstructive pulmonary disease (COPD) patients and a challenge to develop new anti-inflammatory therapies. In previous reports we showed that cytoplasmic tail of the membrain tethered mucin 1 (MUC1-CT) interacts with glucocorticoid receptor (GR) mediating corticosteroid anti-inflammatory efficacy. Objectives: To analyze the role of MUC1-CT as a key marker of corticosteroid efficacy in COPD Methods: The expression of MUC1-CT and the anti-inflammatory role of dexamethasone were evaluated in neutrophils and bronchial epithelial cells from healthy and COPD patients. Anti-inflammatory effects of dexamethasone and glucocorti…
Hybrid Observer for Indoor Localization with Random Time-of-Arrival Measurments
2018
In this work an indoor position estimation algorithm will be proposed. The position will be measured by means of a sensor network composed by fixed beacons placed on the indoor environment and a mobile beacon mounted on the object to be tracked. The mobile beacon communicates with all the fixed beacons by means of ultra wide-band signals, and the distance between them is computed by means of time of flight techniques. Moreover, inertial measurements will be used when the position measurements are not available. Two main problems will be considered in the proposed architecture: the fact that the beacons work with a lower update rate than the IMU, and that the mobile beacon can comunicate wit…
Localization from inertial data and sporadic position measurements
2020
A novel estimation strategy for inertial navigation in indoor/outdoor environments is proposed with a specific attention to the sporadic nature of the non-periodic measurements. After introducing the inertial navigation model, we introduce an observer providing an asymptotic estimate of the plant state. We use a hybrid dynamical systems representation for our results, in order to provide an effective, and elegant theoretical framework. The estimation error dynamics with the proposed observer shows a peculiar cascaded interconnection of three subsystems (allowing for intuitive gain tuning), with perturbations occurring either on the jump or on the flow dynamics (depending on the specific sub…
Seismic Network Evaluation through Simulation: An Application to the Italian National Seismic Network
2011
Abstract A properly organized seismic network is a valuable tool for monitoring seismic zones and assessing seismic hazards. In this paper we propose a new method (seismic network evaluation through simulation, SNES) to evaluate the performance of hypocenter location of a seismic network. The SNES method gives, as a function of magnitude, hypocentral depth, and confidence level, the spatial distribution of the number of active stations in the location procedure and their relative azimuthal gaps, along with confidence intervals in hypocentral parameters. The application of the SNES method also permits evaluation of the magnitude of completeness ( M C ), the background noise levels at the sta…
Post-translational modifications in the survival motor neuron protein
2004
Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by a progressive loss of the spinal motoneurons. The SMA-determining gene has been termed survival motor neuron (SMN) and is deleted or mutated in over 98% of patients. The encoded gene product is a protein expressed as different isoforms. In particular, we showed that the rat SMN cDNA produces two isoforms with Mr of 32 and 35 kDa, both localized in nuclear coiled bodies, but the 32 kDa form is also cytoplasmic, whereas the 35 kDa form is also microsomal. To determine the molecular relationship between these two isoforms and potential post-translational modifications, we performed transfection experiments with a …
Dissection of human papillomavirus type 33 L2 domains involved in nuclear domains (ND) 10 homing and reorganization
2003
Abstract We have recently shown that the minor capsid protein L2 of human papillomavirus type 33 (HPV33) recruits the transcriptional repressor Daxx into nuclear domains (ND) 10 and causes the loss of the transcriptional activator Sp100 from these subnuclear structures (Florin et al., 2002b) . In order to dissect L2 domains involved in nuclear translocation, ND10 homing, loss of Sp100, and recruitment of Daxx, a detailed deletion mutagenesis of L2 was performed. Using immunofluorescence and green fluorescent protein fusions, we have identified two nuclear localization signals (NLS) in the central and C-terminal part of L2, respectively, homologous to previously identified NLS in HPV6B L2 (S…
Interaction of syntenin-1 and the NG2 proteoglycan in migratory oligodendrocyte precursor cells.
2008
Migration of oligodendrocyte precursors along axons is a necessary prerequisite for myelination, but little is known about underlying mechanisms. NG2 is a large membrane proteoglycan implicated in oligodendrocyte migration. Here we show that a PDZ domain protein termed syntenin-1 interacts with NG2 and that syntenin-1 is necessary for normal rates of migration. The association of syntenin-1 with NG2, identified in a yeast two-hybrid screen, was confirmed by colocalization of both proteins within processes of oligodendroglial precursor cells and by coimmunoprecipitation from cell extracts. Syntenin-1 also colocalizes with NG2 in "co-capping" assays, demonstrating a lateral association of bot…