Search results for "Location"
showing 10 items of 1480 documents
Broker and Federation Based Cloud Networking Architecture for IaaS and NaaS QoS Guarantee
2016
International audience; Today, the Cloud networking aspect is a critical factor for adopting the Cloud computing approach. The main drawback of Cloud networking consists in the lack of Quality of Service (QoS) guarantee and management in conformance with a corresponding Service Level Agreement (SLA). This paper presents a framework for resource allocation according to an end-to-end SLA established between a Cloud Service User (CSU) and several Cloud Service Providers (CSPs) in a Cloud networking environment. We focus on QoS parameters for Network as a Service (NaaS) and Infrastructure as a Service (IaaS) services. In addition, we propose algorithms for the best CSPs selection to allocate Vi…
GRASP and tabu search for the generalized dispersion problem
2021
Abstract The problem of maximizing dispersion requires the selection of a specific number of elements from a given set, in such a way that the minimum distance between the pairs of selected elements is maximized. In recent years, this problem has received a lot of attention and has been solved with many complex heuristics. However, there is a recent variant in which the selected elements have to satisfy two realistic constraints, a minimum capacity limit and a maximum budget, which in spite of its practical significance in facility location, has received little attention. In this paper, we first propose mathematical models to obtain the optimal solution of small- and medium-size instances, …
Learning automata-based solutions to the optimal web polling problem modelled as a nonlinear fractional knapsack problem
2011
We consider the problem of polling web pages as a strategy for monitoring the world wide web. The problem consists of repeatedly polling a selection of web pages so that changes that occur over time are detected. In particular, we consider the case where we are constrained to poll a maximum number of web pages per unit of time, and this constraint is typically dictated by the governing communication bandwidth, and by the speed limitations associated with the processing. Since only a fraction of the web pages can be polled within a given unit of time, the issue at stake is one of determining which web pages are to be polled, and we attempt to do it in a manner that maximizes the number of ch…
Improving the performance of embedded systems with variable neighborhood search
2017
Graphical abstractDisplay Omitted Embedded systems have become an essential part of our lives, mainly due to the evolution of technology in the last years. However, the power consumption of these devices is one of their most important drawbacks. It has been proven that an efficient use of the memory of the device also improves its energy performance. This work efficiently solves the dynamic memory allocation problem, which can be formally defined as follows: given a program that has to be executed by a circuit, the objective is to fit that program in memory in such a way that the computing time required to execute it is minimized. In this work, we propose a parallel variable neighborhood se…
Genomic and transcriptomic profiling of resistant CEM/ADR-5000 and sensitive CCRF-CEM leukaemia cells for unravelling the full complexity of multi-fa…
2016
AbstractWe systematically characterised multifactorial multidrug resistance (MDR) in CEM/ADR5000 cells, a doxorubicin-resistant sub-line derived from drug-sensitive, parental CCRF-CEM cells developed in vitro. RNA sequencing and network analyses (Ingenuity Pathway Analysis) were performed. Chromosomal aberrations were identified by array-comparative genomic hybridisation (aCGH) and multicolour fluorescence in situ hybridisation (mFISH). Fifteen ATP-binding cassette transporters and numerous new genes were overexpressed in CEM/ADR5000 cells. The basic karyotype in CCRF-CEM cells consisted of 47, XX, der(5)t(5;14) (q35.33;q32.3), del(9) (p14.1), +20. CEM/ADR5000 cells acquired additional aber…
The genetic prehistory of the Baltic Sea region
2018
Correction: Nature communications 9 (2018), art. no. 1494 doi:10.1038/s41467-018-03872-y While the series of events that shaped the transition between foraging societies and food producers are well described for Central and Southern Europe, genetic evidence from Northern Europe surrounding the Baltic Sea is still sparse. Here, we report genome-wide DNA data from 38 ancient North Europeans ranging from similar to 9500 to 2200 years before present. Our analysis provides genetic evidence that hunter-gatherers settled Scandinavia via two routes. We reveal that the first Scandinavian farmers derive their ancestry from Anatolia 1000 years earlier than previously demonstrated. The range of Mesolit…
CellMap visualizes protein-protein interactions and subcellular localization
2018
Many tools visualize protein-protein interaction (PPI) networks. The tool introduced here, CellMap, adds one crucial novelty by visualizing PPI networks in the context of subcellular localization, i.e. the location in the cell or cellular component in which a PPI happens. Users can upload images of cells and define areas of interest against which PPIs for selected proteins are displayed (by default on a cartoon of a cell). Annotations of localization are provided by the user or through our in-house database. The visualizer and server are written in JavaScript, making CellMap easy to customize and to extend by researchers and developers.
Intervention of Inflammatory Monocyte Activity Limits Dermal Fibrosis
2019
Monocytes and monocyte-derived cells are important players in the initiation, progression, and resolution of inflammatory skin reactions. As inflammation is a prerequisite for fibrosis development, we focused on the role of monocytes in cutaneous fibrosis, the clinical hallmark of patients suffering from systemic sclerosis. Investigating the function of monocytes in reactive oxygen species–induced dermal fibrosis, we observed that early monocyte depletion partially reduced disease severity. Low numbers of inflammatory Ly6Chigh monocytes, as well as inhibition of CCR2 and CCL2 in wild type animals by a specific L-RNA aptamer, mitigated disease parameters, indicating a pivotal role for CCR2+ …
Activation of silent mating type information regulation 2 homolog 1 by human chorionic gonadotropin exerts a therapeutic effect on hepatic injury and…
2017
Incidence and prevalence of inflammatory liver diseases has increased over the last years, but therapeutic options are limited. Pregnancy induces a state of immune tolerance, which can result in spontaneous improvement of clinical symptoms of certain autoimmune diseases including autoimmune hepatitis (AIH). We investigated the immune-suppressive mechanisms of the human pregnancy hormone, chorionic gonadotropin (hCG), in the liver. hCG signaling activates silent mating type information regulation 2 homolog 1 (SIRT1), which deacetylates forkhead box o3 (FOXO3a), leading to repression of proapoptotic gene expression, because the immunosuppressive consequence attributed to the absence of caspas…
Microenvironments to study migration and somal translocation in cortical neurons
2018
Migrating post-mitotic neurons of the developing cerebral cortex undergo terminal somal translocation (ST) when they reach their final destination in the cortical plate. This process is crucial for proper cortical layering and its perturbation can lead to brain dysfunction. Here we present a reductionist biomaterials platform that faithfully supports and controls the distinct phases of terminal ST in vitro. We developed microenvironments with different adhesive molecules to support neuronal attachment, neurite extension, and migration in distinct manners. Efficient ST occurred when the leading process of migratory neurons crossed from low-to high-adhesive areas on a substrate, promoting spr…