Search results for "Locke"
showing 10 items of 332 documents
Application of the collective coordinate method to the analysis of the dynamics of mode-locked fiber lasers
2015
Mode-locked fiber laser are among the few systems that allow to achieve a variety of elaborate optical functions, by means of few optical components. The use of dispersion management brings to this type of lasers a variety of behaviors, which is so rich that the complete mapping and detailed analysis of the stable states becomes impractical when conventional tools based on the intra-cavity field propagation equations, are used. In this thesis we show that the addition of the technique ofcollective coordinates to the conventional theoretical tools, allows to solve at least in part the problem of complexity and diversity of the stable states of the cavity. In particular, we propose the DCCA (…
Ambulatory Blood Pressure Values in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial (ONTARGET)
2012
In the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial, telmisartan (T; 80 mg daily) and ramipril (R; 10 mg daily) caused similar clinic blood pressure (BP) reductions, with a similar incidence of cardiovascular and renal events. The R+T combination lowered clinic BP somewhat more with no further cardiovascular or renal protection. The aim of this substudy was to see whether these clinic BP changes reflected the changes of 24-hour BP, a BP with a better prognostic value. In 422 patients in whom 24-hour BP monitoring was performed either before or after 6 to 24 months of treatment, demographic and clinical characteristics were similar in the 3 treated groups.…
Antihypertensive and cardiovascular effects of combined blockade of renin-angiotensin system with ACE inhibitor and angiotensin II type 1 receptor bl…
2006
BACKGROUND.: In this study the effects of 24 weeks losartan and ramipril treatment, both alone and in combination, on blood pressure and left ventricular mass (LVM) and function, have been evaluated in hypertensives. METHODS.: 57 hypertensives with stage 1 and 2 essential hypertension were included. After 4 weeks run in, a randomized double-blind, 3 arm, double dummy, independent trial was used. All patients were randomly allocated to 3 treatment arms consisting of losartan (50 mg/daily), ramipril (5 mg/daily), and combined (losartan 50 mg/ramipril 5 mg/daily) for 24 weeks. LVM, LVM/h(2.7) and other echocardiographic measurements, BUN, creatinine and clearance and potassium were determined …
Cardiovascular outcomes and achieved blood pressure in patients with and without diabetes at high cardiovascular risk
2019
Abstract Aims Studies have shown a non-linear relationship between systolic blood pressure (SBP) and diastolic blood pressure (DBP) and outcomes, with increased risk observed at both low and high blood pressure (BP) levels. We hypothesized that the BP-risk association is different in individuals with and without diabetes at high cardiovascular risk. Methods and results We identified patients with (N = 11 487) or without diabetes (N = 19 450), from 30 937 patients, from 133 centres in 44 countries with a median follow-up of 56 months in the ONTARGET/TRANSCEND studies. Patients had a prior history of stroke, myocardial infarction (MI), peripheral artery disease, or were high-risk diabetics. P…
Kestävyyttä tukevat hallintokäytännöt – vapaa-ajankalastajien näkemyksiä Järvi-Suomen taimen- ja järvilohikantojen hoidosta ja kalastuksen säätelystä
2019
Vapaa-ajankalastus on Suomessa hyvin suosittua ja sitä harjoitetaan kaikilla järvialueilla. Kalastuksen kohteena on yleensä useita kalalajeja ja käytössä on useita eri kalastustapoja, hyvin yleisesti myös verkkoja. Vapaa-ajankalastus muodostaa uhan useiden lajien kestävyydelle ja erityisesti se estää uhanalaisen järvilohen ja vaarantuneen järvitaimenen kantojen palautumisen. Nämä lajit taantuivat vesivoiman rakentamisen seurauksena.
 Suomen sisävesien hallinto on yhdistelmä keskusjohtoista ja alueellista hallintoa, jossa eri kalastajaryhmien osallistuminen on muodollisesti järjestetty. Käytännön päätöksenteko on keskittynyt paikallisille maanomistajille. Tähän mennessä kalastajien sää…
Two distinct Ca2+ influx pathways activated by the bradykinin B2 receptor.
1996
The hormone-induced depletion of cellular Ca stores provides a signal for the Ca2+ influx into electrically non-excitable cells; however, the underlying molecular mechanisms remain elusive. Therefore, we analyzed bradykinin-activated Ca2+ influx into human foreskin fibroblast cells, HF-15, by fura-2 and 45Ca labeling to discriminate between Ca2+ influx into the fura-sensitive compartment and Ca uptake into fura-insensitive Ca stores. Bradykinin-activated CaZt influx into the fura-sensitive compartment was blocked by inhibitors of NO synthases. These inhibitors also suppressed bradykinin-activated increases in cGMP, indicating that the NO-dependent increase in cGMP is involved in the activat…
Latent tubercolosis infection in patients with cronic plaque psoriasis: evidence from the Italian Psocare Registry
2015
SummaryBackground The nationwide prevalence of latent tuberculosis infection (LTBI) in Italian patients with psoriasis has never been investigated. Objectives To estimate the nationwide prevalence of LTBI in Italian patients with psoriasis who are candidates for systemic treatment. Methods Data were obtained from the Psocare Registry on those patients (n = 4946) with age > 18 years, systemic treatment at entry specified and tuberculin skin test (TST) performed according to the Mantoux method. LTBI diagnosis was based on a positive TST result in the absence of any clinical, radiological or microbiological evidence of active tuberculosis. Results Latent tuberculosis infection was diagnosed in…
Hidden attractors in dynamical models of phase-locked loop circuits : limitations of simulation in MATLAB and SPICE
2017
During recent years it has been shown that hidden oscillations, whose basin of attraction does not overlap with small neighborhoods of equilibria, may significantly complicate simulation of dynamical models, lead to unreliable results and wrong conclusions, and cause serious damage in drilling systems, aircrafts control systems, electromechanical systems, and other applications. This article provides a survey of various phase-locked loop based circuits (used in satellite navigation systems, optical, and digital communication), where such difficulties take place in MATLAB and SPICE. Considered examples can be used for testing other phase-locked loop based circuits and simulation tools, and m…
Coherent master equation for laser modelocking
2020
Modelocked lasers constitute the fundamental source of optically-coherent ultrashort-pulsed radiation, with huge impact in science and technology. Their modeling largely rests on the master equation (ME) approach introduced in 1975 by Hermann A. Haus. However, that description fails when the medium dynamics is fast and, ultimately, when light-matter quantum coherence is relevant. Here we set a rigorous and general ME framework, the coherent ME (CME), that overcomes both limitations. The CME predicts strong deviations from Haus ME, which we substantiate through an amplitude-modulated semiconductor laser experiment. Accounting for coherent effects, like the Risken-Nummedal-Graham-Haken multim…
Vehicle routing with private and shared delivery locations
2021
Abstract The rapid growth of e-commerce has led to an increase of home delivery requests. Providing efficient distribution systems for services on the last mile has become a challenging issue for logistics companies, where a trade-off between the classical approaches, attended home delivery (AHD) and usage of shared delivery locations (SDLs) has been identified. AHD provides a higher quality of service but implies very high costs for the company, while usage of SDL requires customers to perform the very last mile by themselves. For companies, this bears the risk of a decrease in the perceived service quality. However, due to consolidation effects, transportation costs can be considerably mi…