Search results for "Locke"
showing 10 items of 332 documents
Caratterizzazione funzionale e strutturale di un isolatore cromatinico localizzato tra i geni c-Myc e Pvt-1 umani
2008
Thanatos associated protein 11 (THAP11) modulates expression of c-MYC by binding the HB2.8 enhancer blocker element.
2014
UNA PROCEDURA AUTOMATIZZATA PER LA DETERMINAZIONE DELLE CARATTERISTICHE MICROSTRUTTURALI DELLE SABBIE MEDIANTE ANALISI DI IMMAGINI DI SEZIONI SOTTILI
2012
È ben noto che il comportamento meccanico microscopico delle sabbie - e in generale dei terreni granulari - trae origine dalle loro caratteristiche microstrutturali, quali, per esempio, il numero di coordinazione dei singoli grani, l’indice di contatto intergranulare (grain contact ratio) e l’indice di addensamento dei grani (packing density index). Appare, quindi, di notevole importanza la determinazione degli indici predetti con alto grado di affidabilità e di ripetibilità. Lo studio dell’assetto dei contatti intergranulari e il calcolo degli indici che lo caratterizzano, viene condotta comunemente su immagini piane dell’insieme di grani mediante esame visuale e restituzione grafica assis…
Antihypertensive and cardiovascular effects of combined blockade of renin-angiotensin system with ACE inhibitor and angiotensin II type 1 receptor bl…
2006
Background: In this study the effects of 24 weeks losartan and ramipril treatment, both alone and in combination, on blood pressure and left ventricular mass (LVM) and function,have been evaluated in hypertensives. Methods. 57 hypertensives with stage 1 and 2 essential hypertension were included. After 4 weeks run in, a randomized double-blind, 3 arm, double dummy, independent trial was used. All patients were randomly allocated to 3 treatment arms consisting of losartan (50 mg/daily), ramipril (5 mg/daily), and combined (losartan 50 mg/ramipril 5 mg/daily) for 24 weeks. LVM, LVM/h and other echocardiographic measurements, BUN, creatinine and clearance and potassium were determined after ru…
Therapeutic management of elderly hypertensives with concomitant ischaemic heart disease.
1992
CHARACTERISTICS OF ELDERLY HYPERTENSIVES: Hypertension is most prevalent in older patients and is associated with increasing morbidity and mortality with age. Elderly hypertensives often suffer from concomitant diseases, such as ischaemic heart disease, caused by age-induced modifications to the cardiovascular system, haemodynamic function and neurohormone activity. THERAPEUTIC MANAGEMENT: Therapeutic management of elderly hypertensives with concomitant ischaemic heart disease must take account of the pharmacodynamic and pharmacokinetic changes that occur in older subjects and drugs should be selected for their efficacy in both diseases. Since elderly subjects often metabolize drugs more sl…
Dissipative shock waves in all-normal-dispersion mode-locked fiber lasers
2014
4 pags.; 4 figs.; OCIS codes: (140.4050) Mode-locked lasers; (140.3510) Lasers, fiber.
Energy efficient modulation of dendritic processing functions
1998
The voltage dependent ionic conductances and the passive properties of the neural membrane determine how external inputs are processed by the dendritic tree, and define the computational characteristics of neurons. However, what controls these characteristics and how they are implemented at the single neuron level, in such a way that an external input results in the coding of the appropriate output, is essentially unknown. We show here that a slow inactivation of the Na+ channel, involved in the attenuation and/or failure of APs in the dendrites, acts as an active and energy efficient filter of synaptic input, and results in an activity-dependent control of the properties of individual neur…
α-Adrenoceptor Interaction of Tetrandrine and Isotetrandrine in the Rat: Functional and Binding Assays
1998
Abstract The action of 1S,1′S-tetrandrine, a bisbenzyltetrahydroisoquinoline alkaloid, on α1-adrenoceptors has been compared with that of its isomer 1R,1′S-isotetrandrine. The work includes binding assays to analyse the affinity of these products for the [3H]prazosin binding site of rat cerebral cortical membranes and functional studies on rat isolated aorta to examine the effects of both alkaloids on intracellular calcium processes related or not to α-adrenoceptor activation. A radioligand receptor-binding study showed that both compounds interacted with the α1-adrenoceptors displacing [3H]prazosin from the specific binding site. The Ki values (inhibition constants) were 0.69±0.12 and 1.6±…
RELEASE BY SYMPATHETIC STIMULATION OF ALPHA-METHYLNORADRENALINE STORED IN THE HEART AFTER ADMINISTRATION OF ALPHA-METHYLDOPA.
1963
Dans les cœurs de lapins traites par l'α-methyldopa, la depletion de la noradrenaline s'accompagne d'une fixation importante d'α-methylnoradrenaline. Sous l'effet de stimulation sympathique ou d'iodure de dimethylphenyl-piperazinium, ces cœurs liberent conjointement de la noradrenaline et de l'α-methylnoradrenaline.
A self-synchronizing instrument for harmonic sources detection in power systems
2004
The deregulation of energy markets holds out new prospects for contract between customers and utilities, in which the price of energy can depend on voltage quality and load characteristics, as well as on the responsibility for disturbances caused to supply voltage in power systems. In this context, harmonic sources detection is one of the main problems, because of equipment sensibility and the proliferation of loads which absorb non-sinusoidal currents. In this paper the authors present a new instrument based on a time domain method for the detection of harmonic active powers in three-phase systems, which can be usefully applied even in the presence of unbalance or asymmetry. The amplitude …