Search results for "Locke"
showing 10 items of 332 documents
THAP11 and HP1BP3 proteins are component of the HB-2.8 enhancer-blocker located in the human c-MYC chromatin domain.
2011
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channe…
2021
Multitarget-directed ligands (MTDLs) are considered a promising therapeutic strategy to address the multifactorial nature of Alzheimer's disease (AD). Novel MTDLs have been designed as inhibitors of human acetylcholinesterases/butyrylcholinesterases, monoamine oxidase A/B, and glycogen synthase kinase 3β and as calcium channel antagonists via the Biginelli multicomponent reaction. Among these MTDLs, (±)-BIGI-3h was identified as a promising new hit compound showing in vitro balanced activities toward the aforementioned recognized AD targets. Additional in vitro studies demonstrated antioxidant effects and brain penetration, along with the ability to inhibit the aggregation of both τ protein…
Entre Robinson y Frankenstein. Los derechos y los deberes en el "modelo criatural"
2012
:A partir de una perspectiva “literaria”, basada en las figuras de los famosos protagonistas de dos novelas modernas (el “marinero” Robinson Crusoe y el “monstruo” Frankenstein), este ensayo examina la relación entre los derechos y los deberes en el “modelo criatural”, con especial referencia a la filosofía jurídica de John Locke, en el intento de denunciar sus límites y proponer su superación.ABSTRACT:On the grounds of a “literary” perspective, based on the figures of the protagonists of two famous modern novels (the “sailor” Robinson Crusoe and the “monster” Frankenstein), this essay investigates the relationship between rights and duties in the so called “workmanship model”, with particu…
Selective chiral inhibition of Ca2+ entry promoted by bisbenzyltetrahydroisoquinolines in rat uterus.
1992
Abstract The effects of diltiazem and six bisbenzyltetrahydroisoquinoline alkaloids (antioquine, 7-O-methylantioquine, dimethylantioquine, monterine, granjine and cordobimine) were studied in rat isolated uterus in order to clarify the mechanisms of their relaxant actions. All the compounds tested completely relaxed KCl-induced contractions and totally or partially inhibited oxytocin-induced rhythmic contractions. Only alkaloids with absolute configurations (1R,1′S or 1R,1′R) acted intracellularly, promoting relaxation of contractile responses induced by oxytocin in a Ca2+-free medium, as does papaverine. Alkaloids of the antioquine series (1S,1′R) selectively inhibited Ca2+ entry. The grea…
Performance analysis of dual-pump nonlinear amplifying loop mirror mode-locked all-fibre laser
2019
We numerically characterise, in the three-dimensional space of adjustable cavity parameters, the performance of a recently reported layout of a flexible figure-8 laser having two independently pumped segments of active fibre in its bidirectional ring (Smirnov et al 2017 Opt. Lett. 42 1732–5). We show that this optimisation problem can be efficiently addressed by applying a regression model based on a neural-network algorithm.
Historical model of settling and spread of Bell Beakers Culture in the mediterranean France
2004
Die Glockenbecherkultur im mediterranen Südfrankreich : ein historisches InterpretationsmodellIm Folgenden werden einige Teilergebnisse aus einer Dissertation vorgestellt, die im März 2002 an der Universität Aix-en-Provence vorgelegt wurde (Lemercier 2002). In dieser Arbeit wurden sämtliche Glockenbecher-Elemente (1200 verzierte Gefässe bzw. Gefässfragmente) aus über 300 südostfranzösischen Fundstellen mit annähernd berücksichtigt. Diese Untersuchung bestätigt das Vorhandensein von vier Stilgruppen und die Gültigkeit der von J. Guilaine auf der Basis der verzierten Keramik vorgeschlagenen Chronologie weitgehend. Die Analyse dieser Gruppen, ihrer Fundumstände und ihrer Verbreitung führt uns …
Essays on early modern conceptions of consciousness: Descartes, Cudworth, and Locke
2009
Classification of current anticancer immunotherapies.
2014
© 2014. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Synthetic approach to the design of wide-band microwave injection-locked amplifiers
2010
In this work, a synthesis-based approach to the realization of wide-band microwave injection-locked amplifiers (ILA) is proposed. To this purpose, a transmission-type topology is combined with a feedback structure in which the "core ILA" is intentionally separated from the output (power) amplifier. A modular, matched, design of individual building blocks of the core ILA is then adopted, which allows their first-approximation exact modeling in the dynamical complex-envelope domain, following the theory earlier developed by Calandra-Sommariva. On this basis, analytic expressions for the main operating characteristics of the ILA (such as the locking bandwidth under small signal operation) are …
Approach to the Design of Transmission-Type Injection-Locked Microwave Oscillators through Behavioral Block Modeling
2010
In this work, an attempt is made toward the development of a systematic design method for the performance- driven dimensioning of the various elements comprising the structure of modern transistor-based microwave injection- locked oscillators with transmission-type topologies (TILOs). The proposed approach is based on the use of appropriate diakoptics of the various circuit blocks into a matched environment, and their behavioral modeling in the fundamental- frequency dynamical complex envelope domain with the help of standard circuit and E.M. simulation CAD tools. This will permit, in the end, to obtain closed-form expressions for the main TILO performances in terms of the design parameters…