Search results for "Long"

showing 10 items of 3969 documents

Dietary Patterns and Healthy Ageing

2021

Ageing is a complex process in which multiple factors are involved that can contribute to determine whether a person will or not be affected by diseases that are more frequently observed in advanced age. The factors involved comprise genetic, environmental, behavioural, and dietary factors, which influence pathways that regulate the ageing process and the life expectancy, rendering longevity a multifaceted phenomenon. Even if a miraculous elixir or pill is not yet available, there is general agreement that nutrition has a major impact on the overall mortality and on the development of age-related chronic non-communicable diseases. Nutrition research has focused for decades on single nutrien…

business.industrymedia_common.quotation_subjectLongevityDietary factorsmedicine.diseaseNutrientAgeingEnvironmental healthmedicineLife expectancyDementiaHealthy ageingNutrition researchbusinessmedia_common
researchProduct

Multifibrillar bundles of a self-assembling hyaluronic acid derivative obtained through a microfluidic technique for aortic smooth muscle cell orient…

2018

A hyaluronic acid derivative that is able to physically crosslink in a saline aqueous environment was employed for the production of fibers with a mean diameter of 50 μm using a microfluidic technique. The microfibers were collected in a tailored rotating collector and assembled to form multifibrillar bundles. The orientation of the microfibers on the collected bundles was evaluated by microCT analysis. The bundles were biofunctionalized by physical addition of fibronectin or chemical tethering of a cyRGDC peptide to achieve control of Aortic Smooth Muscle Cell (AoSMC) attachment, elongation and alignment. The mechanical performances of these bundles were evaluated by elongation tests, rela…

business.product_categoryMaterials scienceMicrofluidicsMyocytes Smooth MuscleMicrofluidicsCellBiomedical Engineering02 engineering and technology010402 general chemistryPeptides Cyclic01 natural scienceschemistry.chemical_compoundMicrofiberHyaluronic acidMicroscopyCell AdhesionmedicineGeneral Materials ScienceHyaluronic AcidAortabiologyN.D.Cell Differentiation021001 nanoscience & nanotechnologyFibronectins0104 chemical sciencesFibronectinmedicine.anatomical_structurechemistrySettore CHIM/09 - Farmaceutico Tecnologico Applicativobiology.proteinSurface modificationMaterials Science (all)Elongation0210 nano-technologybusinessOligopeptidesBiomedical engineeringBiomaterials Science
researchProduct

Sport and Quality of Life

2022

Negli ultimi trent’anni lo sport ha assunto un significato molto rilevante nella vita delle persone e, seppure con notevoli differenze, sia nei paesi a sviluppo economico avanzato, sia in quelli in via di sviluppo. A livello individuale, esso ha costituito un’area di investimento identitario quando ha assunto la forma di sport spettacolo del quale fruire, alimentando la pratica del tifo e il fandom o costituendo il modello di uno stile di vita vincente; ma anche quando ha assunto la forma di pratica del tempo libero attraverso la quale tenersi in forma, facendo crescere, in questo caso, la diffusione di una cultura della salute e del benessere. Si tratta di due modalità di approcciare al co…

but also when he took the form of free time practice through which to keep fit making grow in this case the diffusion of a culture of health and well-being. These are two ways of approaching the consumption of sports by spectators and actorIn the last thirty years sport has taken on a very significant meaning in people's lives and albeit with considerable differences both in advanced economic development countries and in developing countries. On an individual level it constituted an area of identity investment when it assumed the shape of “sport spectacle” to be enjoyed fueling the practice of cheering and fandom or constituting the model of a winning lifestyleand the two ways of use can be strongly related to the perception and assessment of the quality of life. The “semantic universes” which however connote sport and “free time sports” have often appeared polarized. Commercial sport and sports professionalism are intertwined with the institutions of economics politics and culture which above all stress its “spectacularity” in order to capture first and foremost the audience. But also the sport of leisure time is intertwined with the actions of the institutions of economics politics and culture with the difference that these stress above all its “healthy value” aimed at the “healthy and rational” investment of time in an activity which improves the quality of life in the short medium and long period. This polarization between the consumption of sport entertainment - commercial sport - and the consumption of sport as a leisure activity - sport for all - has become increasingly interconnected precisely because of the increased collective identity demand via sport. In other words we have witnessed the spread of shape of sports entertainment that recall the importance of sports for psychophysical well-being for integration and social participation for the reduction of social inequalities ethnic and cultural differences and in which the importance assumed was weakened in the show from agonism from competition from the physical confrontation between two contenders or two teams. A sport in which we act with competitors as well as against competitors. And on the other hand we have gradually witnessed the spectacularization of sports in our free time to the point that the sharing of the results obtained through the declination of a competitive spirit that presents itself as directed no longer against other contenders but against its own performance limits it has become the way in which each person makes part of his or her own life spectacular the one he often considers most authentic. The aim of this work is to describe how the intertwining between the commercial/professional dimension of the sports show and the playful/recreational dimension of sports practice are fueled by a demand and an offer of social identity that characterizes these two “semantic universes”.Settore SPS/07 - Sociologia Generale
researchProduct

Externalizing Behaviors and Cigarette Smoking as Predictors for Use of Illicit Drugs: A Longitudinal Study Among Finnish Adolescent Twins

2010

We examined whether externalizing problem behaviors (hyperactivity–impulsivity, aggressiveness, and inattention) predict illicit drug use independently, or whether their associations with drug use are mediated through cigarette smoking. We used a prospective longitudinal design within theFinnTwin12-17study among Finnish adolescents with baseline at age 12 and follow-up surveys at ages 14 and 17. Path models were conducted withMplusand included 1992 boys and 2123 girls. The outcome was self-reported ever use of cannabis or other illicit drugs at age 17. The predictors were: externalizing behaviors (hyperactivity–impulsivity, aggressiveness, and inattention) assessed by teachers and parents (…

cannabisMaleLongitudinal studyexternalizing behaviorPsychological interventioncigarette smokinginattentiontobacco0302 clinical medicineadolescents030212 general & internal medicineLongitudinal StudiesProspective StudiesProspective cohort studyChildGenetics (clinical)FinlandInternal-External Controlmedia_commonbiologySmokingObstetrics and Gynecologyhyperactivity-impulsivitySubstance Abuse DetectionConduct disorderTwin Studies as TopicFemalePsychologyDrugConduct Disordermedicine.medical_specialtyMediation (statistics)AdolescentSubstance-Related Disordersmedia_common.quotation_subjectillicit drugsArticle03 medical and health sciencesCigarette smokingmedicineHumansPsychiatryIllicit Drugsaggressivenessmedicine.diseasebiology.organism_classificationAdolescent BehaviorPediatrics Perinatology and Child HealthCannabisDevelopmental Psychopathology030217 neurology & neurosurgery
researchProduct

Toma de decisiones gerenciales: una aproximación a través de simulación

2018

RESUMEN Las decisiones gerenciales relacionadas con las inversiones en el desarrollo de recursos estratégicos, constituyen un aspecto clave en la formulación de las estrategias organizativas, y dado el efecto que los recursos estratégicos tienen sobre el desempeño de la firma, se hace pertinente el estudio de este tipo de decisiones, que han sido definidas como una capacidad dinámica gerencial, concepto que se deriva de las capacidades dinámicas de tipo organizativo que permiten a una organización renovar sus competencias cuando son aplicadas, por analogía, a las capacidades de los directivos para gestionar los recursos y competencias organizativos. Al definir este tipo de decisiones como u…

capacidades dinámicasdinámica de sistemasmicromundossimulaciónteoría de prospectosestudios longitudinalesUNESCO::CIENCIAS ECONÓMICASperspectiva basada en recursos:CIENCIAS ECONÓMICAS [UNESCO]
researchProduct

Psychophysical burden and lack of support : Reasons for care workers’ intentions to leave their work in the Nordic countries

2021

Long-term care of older adults is currently suffering from a shortage of trained personnel and high turnover rates. Care work is poorly paid, demanding, increasingly time-bound and both mentally and physically burdensome. In this study, we examined the individual, organisational and economic factors that predict professional care workers’ intentions to leave their current employment, using the NORDCARE survey data (2015, N = 3801) collected in Denmark, Finland, Norway and Sweden. The respondents were mainly practical and assistant nurses. The analysis showed that the predictors of intentions to leave were similar in the four countries. The most consistent organisational predictors of leavin…

care worktyövoiman kysyntäSociology and Political Sciencetyöhyvinvointipitkäaikaishoitotyövoimantarveleaving intentionslong- term carevanhustenhuoltopsychophysical burden03 medical and health sciences0302 clinical medicineNursing050602 political science & public administrationhoiva-ala030212 general & internal medicinetyöelämäolder adults05 social sciencestyövoiman vaihtuvuus0506 political scienceterveydenhuoltohenkilöstöpsykofysiologiaLong-term careWork (electrical)Care workers8. Economic growthhoitohenkilöstölähihoitajatperushoitajathenkilöstöCare workvanhustenhuoltolaitoksetPsychologytyöpaikan vaihtoikääntyneethoitotyö
researchProduct

Ikä, identiteetti ja ohjaava koulutus. Ikääntyvät pitkäaikaistyöttömät oppimisyhteiskunnan haasteena

2007

Piia Silvennoinen tutki väitöskirjassaan, millainen merkitys työvoimapoliittisella koulutuksella on ikääntyvien pitkäaikaistyöttömien elämässä. Koulutusten oletetaan parantavan ikääntyvien pitkäaikaistyöttömien työmarkkinakelpoisuutta ja elämänhallintaa. Silvennoinen haki vastausta siihen, miten ikääntyvät pitkäaikaistyöttömät itse suhtautuvat työvoimapoliittisiin koulutuksiin; onko niistä heille haittaa vai hyötyä. Silvennoinen kertoo, että koulutuksen hyödyllisyyttä arvioidaan sen työllistävän vaikutuksen kautta. – Mitä vähemmän koulutus työllistää, sitä enemmän myös sen muut merkitykset menettävät arvoaan ikääntyvien pitkäaikaistyöttömien elämässä, Silvennoinen toteaa. Nykyinen itseohjau…

career counsellingreflexive modernizationaikuiskoulutusOccupational Guidancetyövoimakoulutuselinikäinen oppiminentyöllistyminenlifelong learninglong-term unemploymenthaastatteluttyöttömättyömarkkinattyöttömyysAdult LearningkoulutusUnemploymentageingohjaava koulutuspitkäaikaistyöttömätidentiteettityövoimapitkäaikaistyöttömyysidentityikääntyneet
researchProduct

How Followers Differing in Career Motivation Gain Career Profits from Transformational Leaders: A Longitudinal Moderated Mediation Model

2017

Although, transformational leadership is among the most thoroughly examined leadership theories, knowledge regarding its association with followers' career outcomes is still limited. Furthermore, the underlying mechanisms explaining how transformational leaders affect their employees' career success are yet not well-understood. Based on theoretical assumptions about the processes involved in setting the goal of “making a career,” we propose an indirect effect of transformational leadership on subjective and objective career success via development opportunities that depends on the level of career motivation of employees. We conducted a longitudinal study with two measurement occasions separ…

career motivationLongitudinal study05 social scienceslcsh:BF1-990050109 social psychologyobjective career successAffect (psychology)Structural equation modelingdevelopment opportunitiesLeadership theoryModerated mediationlcsh:PsychologyTransactional leadershipTransformational leadership0502 economics and businesstransformational leadershipPsychologysubjective career success0501 psychology and cognitive sciencesAssociation (psychology)PsychologySocial psychology050203 business & managementGeneral PsychologyOriginal ResearchFrontiers in Psychology
researchProduct

FATTORI DI RISCHIO CARDIOVASCOLARI E METABOLICI NEI CENTENARI

2011

centenari longevità invecchiamento fattori di rischio infarto ictusSettore MED/09 - Medicina Interna
researchProduct

Hsp60 Protects against Amyloid β Oligomer Synaptic Toxicity via Modification of Toxic Oligomer Conformation

2019

Alzheimer's disease (AD) is the leading cause of dementia worldwide. While the etiology of AD remains uncertain, neurotoxic effects of amyloid beta oligomers (Aβo) on synaptic function, a well-established early event in AD, is an attractive area for the development of novel strategies to modify or cease the disease's progression. In this work, we tested the protective action of the mitochondrial chaperone Hsp60 against Aβo neurotoxicity, by determining the direct effect of Hsp60 in changing Aβo toxic conformations and thus reducing their dysfunctional synaptic binding and consequent suppression of long-term potentiation. Our data suggest that Hsp60 has a direct impact on Aβo, resulting in a…

chaperoninProtein ConformationPhysiologyAmyloid betaCognitive NeuroscienceBiochemistryCell LineMitochondrial ProteinsMice03 medical and health sciences0302 clinical medicinemedicineAnimalsHumanssynaptic toxicityCytotoxicity030304 developmental biology0303 health sciencesAmyloid-β oligomersynaptic plasticityAmyloid beta-PeptidesbiologyChemistryNeurotoxicityLong-term potentiationChaperonin 60Cell BiologyGeneral MedicineAlzheimer's diseaseHsp60medicine.diseaseCell biologyChaperone (protein)SynapsesToxicitySynaptic plasticitybiology.proteinHSP60030217 neurology & neurosurgeryProtein BindingACS Chemical Neuroscience
researchProduct