Search results for "Loo"

Analyzing Cascading Effects in Interdependent Critical Infrastructures

2018

International audience; Critical Infrastructures (CIs) are resources that are essential for the performance of society, including its economy and its security. Large-scale disasters, whether natural or man-made, can have devastating primary (direct) effects on some CI and significant indirect effects (cascading effects) on other CIs, because CIs are interconnected and depend on each other’s services. Recent work by Laugé et al. expressed the dependency values among CIs as dependency matrices for various durations of the primary CI failure. For better preparedness and mitigation of CI failures knowledge of the weak points in CI interdependencies is crucial. To this effect, we have developed …

Serious Game Design for Flooding Triggered by Extreme Weather

2017

Managing crises with limited resources through a serious game is deemed as one of the ways of training and can be regarded as an alternative to a table-top exercise. This article presents the so-called “Operasjon Tyrsdal” serious game, inspired by a real case of extreme weather that hit the west coast of Norway. This reference case is used to add realism to the game. The game is designed for a single player, while the mechanics are framed in such a way that the player will have limited resources, and elevated event pressure over time. Beside applying an iterative Scrum method with seven Sprint cycles, we combined the development work with desk research and used the involvement of testers, i…

2020

Limited data are available regarding strength and endurance training adaptations to occupational physical performance during deployment. This study assessed acute training-induced changes in neuromuscular (electromyography; EMG) and metabolic (blood lactate, BLa) responses during a high-intensity military simulation test (MST), performed in the beginning (PRE) and at the end (POST) of a six-month crisis-management operation. MST time shortened (145 ± 21 vs. 129 ± 16 s, −10 ± 7%, p < 0.001) during the operation. Normalized muscle activity increased from PRE to POST in the hamstring muscles by 87 ± 146% (116 ± 52 vs. 195 ± 139%EMGMVC, p < 0.001) and in the quadriceps by 54 ± 81% (26 ± 8…

Red europea para la investigación de la presión arterial en niños y adolescentes (COST Action CA19115)

2021

Resumen La hipertension arterial es un factor de riesgo cardiovascular y renal modificable. Aunque la mayoria de los resultados adversos ocurren en la edad adulta, la hipertension arterial puede estar presente en etapas tempranas de la vida. Mientras pocos cuestionan la importancia de implementar medidas para identificar y manejar esta afeccion en personas adultas, se ha prestado relativamente poca atencion al problema de la hipertension arterial en ninos y adolescentes. Conocer los origenes de la hipertension arterial es un tema que cada vez esta mas presente en los foros de debate. En este sentido, es absoluta la necesidad de una accion paneuropea con el fin de profundizar en los conocimi…

Umbilical Cord Blood Transplantation in Children and Adults

2018

Umbilical cord blood transplantation (UCBT) from unrelated donors is a suitable option of HSCT for patients in whom it is indicated, and a suitable related or unrelated BM or PB donor is not available in due time.

Dual-sided Mapping During Global Stretch Using a Custom Miniaturized Endocardial Balloon with a Multipurpose Multichannel Acquisition System for Prec…

2017

Acute regional myocardial stretch (STR) is known to induce myocardial electrophysiological modifications via mechano-electric feedback (MEF), including abnormal repolarization, premature excitation and increased complexity of activation leading to the initiation, maintenance and acceleration of arrhythmic events. Due to technical limitations little is known about intramural and endo-epicardial (ENDO-EPI) phenomena during these events. Understanding ENDO-EPI modifications produced by STR through MEF may require a dual-sided approach to simultaneously correlate macroscopic surface modifications and their independent or interconnected components. For that purpose, we optically mapped (OM) the …

Typhoid Fever

2008

Typhoid fever continues to be a serious public health problem, with approximately 22. million cases and more than 200. 000 deaths globally. The disease is most often acquired by ingestion of food or water contaminated by the feces and less frequently by urine or vomitus of patients and carriers. Prolonged low-grade fever, headache, dry cough, alterations of bowel habits, coated tongue, and rose spots are the typical clinical features. Definitive diagnosis requires the isolation of Salmonella enterica serovar Typhi. Supportive serological tests are also used. First-choice antibiotic treatment includes fluoroquinolones or third-generation cephalosporins and reduces the mortality rate from 20%…

Cognate HLA absence in trans diminishes human NK cell education

2016

NK cells are innate lymphocytes with protective functions against viral infections and tumor formation. Human NK cells carry inhibitory killer cell Ig-like receptors (KIRs), which recognize distinct HLAs. NK cells with KIRs for self-HLA molecules acquire superior cytotoxicity against HLA– tumor cells during education for improved missing-self recognition. Here, we reconstituted mice with human hematopoietic cells from donors with homozygous KIR ligands or with a mix of hematopoietic cells from these homozygous donors, allowing assessment of the resulting KIR repertoire and NK cell education. We found that co-reconstitution with 2 KIR ligand–mismatched compartments did not alter the frequenc…

Successful aerobic bioremediation of groundwater contaminated with higher chlorinated phenols by indigenous degrader bacteria

2018

The xenobiotic priority pollutant pentachlorophenol has been used as a timber preservative in a polychlorophenol bulk synthesis product containing also tetrachlorophenol and trichlorophenol. Highly soluble chlorophenol salts have leaked into groundwater, causing severe contamination of large aquifers. Natural attenuation of higher-chlorinated phenols (HCPs: pentachlorophenol + tetrachlorophenol) at historically polluted sites has been inefficient, but a 4-year full scale in situ biostimulation of a chlorophenol-contaminated aquifer by circulation and re-infiltration of aerated groundwater was remarkably successful: pentachlorophenol decreased from 400 μg L−1 to <1 μg L−1 and tetrachlorophen…

2017

Abstract Background Results on the association between prenatal exposure to methylmercury (MeHg) and child neuropsychological development are heterogeneous. Underlying genetic differences across study populations could contribute to this varied response to MeHg. Studies in Drosophila have identified the cytochrome p 450 3A (CYP3A) family as candidate MeHg susceptibility genes. Objectives We evaluated whether genetic variation in CYP3A genes influences the association between prenatal exposure to MeHg and child neuropsychological development. Methods The study population included 2639 children from three birth cohort studies: two subcohorts in Seychelles (SCDS) (n = 1160, 20 and 30 months of…