Search results for "Lope"
showing 10 items of 2014 documents
El análisis marxista de las necesidades sociales
2018
The disappearance of the so-called «real socialism» has concealed the validity of the Marxist analysis of social reality. One of the sets of hypotheses that has best maintained its heuristic capacity is the Marxist theory of needs. The Marxist hypotheses have been developed in debate with other conventional conceptions. Currently, feminism and the ecological analysis of needs are renewing the views of Heller and Habermas.
Iesnieguma apstrāde par darbībām ar kases aparātiem, kases sistēmām, specializētajām ierīcēm vai iekārtām
2016
Iesnieguma apstrāde par darbībām ar kases aparātiem, kases sistēmām, specializētajām ierīcēm vai iekārtām ir specifiski pasūtītājam izstrādātas sistēmas programmatūras papildinājums, kas pievieno jaunu un papildina jau esošo funkcionalitāti, saistībā ar izmaiņām regulējošā likumdošanā. Tā ietver iesniegumu sarakstu un datu apstrādes formu. Iesniegumu apstrāde notiek datorizēti, šo pienākumu veic pasūtītāja darbinieki. Programmatūra izstrādāta vidē Gupta Team Developer, izmantojot projekta ietvaros izstrādātās bibliotēkas.
Emotions in Wikipedia: the role of intended negative events in the expression of sadness and anger in online peer production
2018
ABSTRACTThe online encyclopaedia Wikipedia has strict guidelines for ensuring the objectivity of its content and unbiased language of its articles. Wikipedia also provides articles on negative even...
The relationship between vigilance capacity and physical exercise: a mixed-effects multistudy analysis
2019
We thank to all the participants who took part in the experiment.
Revisiting the didactic triangle: from the particular to the general
2012
Published version of an article in the journal: ZDM. Also available from the publisher at: http://www.springerlink.com/content/61p78l089tnx8rn5/ The basic notion of a didactic triangle is explained with historical annotations on its origins and subsequent theorization in the literature. Instances of its application to classroom environments to demonstrate its representational capabilities are presented. Generalizations of the triangle are proposed that integrate the role of technology, the researcher in mathematics teaching developmental research, and mediating complexes in the student–teacher–content interfaces. Further, the use of the didactic triangle as a heuristic device is also discus…
Data from: Spatio-temporal dynamics of density-dependent dispersal during a population colonisation
2019
Predicting population colonisations requires understanding how spatio-temporal changes in density affect dispersal. Density can inform on fitness prospects, acting as a cue for either habitat quality, or competition over resources. However, when escaping competition, high local density should only increase emigration if lower-density patches are available elsewhere. Few empirical studies on dispersal have considered the effects of density at the local and landscape scale simultaneously. To explore this, we analyze 5 years of individual-based data from an experimental introduction of wild guppies Poecilia reticulata. Natal dispersal showed a decrease in local density dependence as density at…
Morelloflavone, a novel biflavonoid inhibitor of human secretory phospholipase A2 with anti-inflammatory activity
1997
Abstract The flavanonylflavone morelloflavone inhibited secretory phospholipase A 2 (PLA 2 ) in vitro , with a high potency on the human recombinant synovial and bee venom enzymes ( IC 50 = 0.9 and 0.6 μM, respectively). The inhibition was apparently irreversible. In contrast, the compound was inactive on cytosolic PLA 2 activity from human monocytes. Morelloflavone scavenged reactive oxygen species generated by human neutrophils ( IC 50 = 2.7 and 1.8 μM for luminol and lucigenin, respectively) but did not modify cellular responses such as degranulation or eicosanoid release. This biflavonoid exerted anti-inflammatory effects in animal models, with a potent inhibition of 12-O-tetradecanoylp…
5‐Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety
2020
Androgenetic alopecia (AGA) is a multifactorial disease that carries a significant psychological burden with it. Dihydrotestosterone, the main pathogenic androgen in AGA, is produced by conversion of testosterone, which is catalyzed by the 5-alpha reductase (5-AR) isoenzyme family. Finasteride and dutasteride are inhibitors of these enzymes. Finasteride, which is a single receptor 5-alpha reductase inhibitor (5-ARI), acts by blocking dihydrotestosterone (DHT). Dutasteride, a dual receptor DHT blocker, has a higher potency than its predecessor, finasteride. This review corroborates the evidence of superiority of dutasteride over finasteride, and its comparable safety profile concerning ferti…
Activation of a murine autoreactive B cell by immunization with human recombinant autoantigen La/SS-B: Characterization of the autoepitope
1995
Immunization of Balb/c mice with a homogeneously purified recombinant human La/SS-B protein resulted in activation of an autoreactive B cell secreting a novel monoclonal anti-La antibody termed La4B6. La4B6 reacted with La protein from a variety of sources including human, bovine, rat and mouse. ATP blocked the binding of La4B6 to recombinant La protein. The human epitope was identified as consisting of the amino acid sequence SKGRRFKGKGKGN, which includes the proposed ATP-binding site of the La protein. In the human and bovine La protein, the epitope exists as a continuous amino acid sequence. In rat and mouse the epitope was found to consist of the amino acid sequence SKG interrupted by a…
Screening for inhibitors of HIV gp120-CD4 binding using an enzyme-linked immunoabsorbent assay.
1993
Binding of the HIV-1 major viral surface glycoprotein, gp120, to the major cell receptor, CD4, is essential for HIV infection of the target cell and syncytium formation. An enzyme-linked immunoassay using solid phase CD4 was used to quantitate the binding of HIV-1 gp120 to CD4, and to assess the activity and mechanism of action of putative inhibitors of that reaction. Monoclonal antibodies to the gp120 binding site on CD4 (e.g., Leu3a) blocked gp120 binding, while monoclonal antibodies to other portions of CD4 (e.g. OKT4) did not. Both aurintricarboxylic acid and sulfonated polysaccharides (e.g., dextran sulfate) blocked CD4-gp120 interactions by binding to the CD4 component. Human polyclon…