Search results for "Lope"
showing 10 items of 2014 documents
Up-and-Coming Markers: Myeloperoxidase, a Novel Biomarker Test for Heart Failure and Acute Coronary Syndrome Application?
2008
Myeloperoxidase (MPO) is a mammalian enzyme responsible for generation of hypochlorite. The advantage of myeloperoxidase for use as a biomarker in the setting of heart failure and acute coronary syndrome is the early increase of MPO concentration in response to the acute event. In the setting of heart failure the reported independency of coronary artery disease and general inflammation, as indicated by MPO concentration in comparison to other inflammatory markers or in subgroups of patients with ischemic and non-ischemic cardiomyopathy, has to be highlighted. In terms of ACS, inclusion of MPO into a multiple marker strategy might add to enhance diagnosis and therapy decision making. Therefo…
Choosing an ideal pharmacotherapeutic strategy for dyslipidemia in children.
2018
Dyslipdiemia can manifest at a young age, and it is a risk factor for atherosclerotic cardiovascular disease (ASCVD), the principal cause of mortality in developed nations. Therefore, treating it a...
Age-dependent changes of nuclear envelope protein phosphokinase and protein phosphatase activities. Significance for altered nucleo-cytoplasmic mRNA …
1984
Nuclear envelopes are associated with a protein phosphokinase and a phosphoprotein phosphatase, whose activities are modulated by poly(A) in an opposite manner. The activities of these enzymes were determined in nuclear ghosts from liver and oviduct of quails of different age and of different hormone status. Under optimal conditions, kinase activity was found to increase in immature animals 8-fold in response to diethylstilbestrol; co-administration of progesterone had no marked effect on enzyme activity. After the initial burst, the activity of the enzyme increased only slightly during ageing. Two proteins present in nuclear ghosts of Mr 64 000 and of Mr 106 000 are phosphorylated during t…
Trichostasis spinulosa misdiagnosed as alopecia areata.
2020
Impact of Sex Differences and Diabetes on Coronary Atherosclerosis and Ischemic Heart Disease
2018
Cardiovascular diseases (CVD) including coronary artery disease (CAD) and ischemic heart disease (IHD) are the main cause of mortality in industrialized countries. Although it is well known that there is a difference in the risk of these diseases in women and men, current therapy does not consider the sexual dimorphism; i.e., differences in anatomical structures and metabolism of tissues. Here, we discuss how genetic, epigenetic, hormonal, cellular or molecular factors may explain the different CVD risk, especially in high-risk groups such as women with diabetes. We analyze whether sex may modify the effects of diabetes at risk of CAD. Finally, we discuss current diagnostic techniques in th…
Exploring why global health needs are unmet by research efforts: the potential influences of geography, industry and publication incentives
2020
[Background]: It has been well established that research is not addressing health needs in a balanced way — much more research is conducted on diseases with more burden in high-income countries than on those with more burden in lower-income countries. In this study, we explore whether these imbalances persist and inquire about the possible influence of three factors, namely geography, industry and publication incentives.
The subway tunneling technique for distal shunt catheter insertion.
2019
Dear Editor,We read with interest the article by Osman et al. titled ‘Trocar assisted distal shunt tube insertion with intra-operative X-Ray confirmation’. The authors purpose their technique to pl...
Neumoencefalo a tensión tras herida en cuero cabelludo en portadora de válvula de derivación ventrículo-peritoneal: caso clínico y revisión de la lit…
2009
El neumoencéfalo se produce la mayoría de las veces por una solución de continuidad en el cráneo e incluso en las meninges. En ocasiones, ciertos factores pueden hacer que éste adopte las características de un neumoencéfalo a tensión provocando una clínica neurológica severa. Presentamos el caso de una paciente de 66 años portadora de una doble válvula de derivación ventrículo-peritoneal que acude a Urgencias con un cuadro de hipertensión intracraneal y que tras la exploración física y la tomografía computarizada se detecta una herida en cuero cabelludo y un neumoencéfalo a tensión. Este defecto en piel se hallaba justo en la zona del borde de una plastia craneal colocada tras la resección …
Effectiveness of Organizational Interventions to Reduce Emergency Department Utilization: A Systematic Review
2012
BackgroundEmergency department (ED) utilization has dramatically increased in developed countries over the last twenty years. Because it has been associated with adverse outcomes, increased costs, and an overload on the hospital organization, several policies have tried to curb this growing trend. The aim of this study is to systematically review the effectiveness of organizational interventions designed to reduce ED utilization.Methodology/principal findingsWe conducted electronic searches using free text and Medical Subject Headings on PubMed and The Cochrane Library to identify studies of ED visits, re-visits and mortality. We performed complementary searches of grey literature, manual s…
Tendencias de la mortalidad por cáncer en españa, en especial del cáncer de pulmón, en comparación con otros países desarrollados
1994
ResumenSe estudia la evolución de la mortalidad global por cáncer en España (1970–1987), y especialmente por cáncer de pulmón, por sexos y grupos de edad, estableciendo comparaciones con otros países (EEUU, Inglaterra y Gales).En cuanto a la evolución de la mortalidad global por cáncer se observa que únicamente en las edades más juveniles se detectan descensos notables de la mortalidad, en tanto que, en los otros países con los que se compara, se observa también una disminución en edades más avanzadas. Asimismo, aunque las tasas de mortalidad por cáncer de pulmón en España tienen unos valores inferiores a los de los países mencionados, se observa un incremento de la mortalidad de ambos sexo…