Search results for "Lps"
showing 10 items of 120 documents
Argan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated re…
2015
In patients with sepsis, liver metabolism and its capacity to provide other organs with energetic substrates are impaired. This and many other pathophysiological changes seen in human patients are reproduced in mice injected with purified endotoxin (lipopolysaccharide, LPS). In the present study, down-regulation of genes involved in hepatic fatty acid oxidation (FAOx) and gluconeogenesis in mice exposed to LPS was challenged by nutritional intervention with Argan oil. Mice given a standard chow supplemented or not with either 6% (w/w) Argan oil (AO) or 6% (w/w) olive oil (OO) prior to exposure to LPS were explored for liver gene expressions assessed by mRNA transcript levels and/or enzyme a…
Reports (1752)IN: Kamari G., Blanché C., Siljak-Yakovlev S. (EDS) Mediterranean Chromosome Number Reports - 21
2011
Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial
2022
PURPOSE Antitumor activity in preclinical models and a phase I study of patients with dedifferentiated liposarcoma (DD-LPS) was observed with selinexor. We evaluated the clinical benefit of selinexor in patients with previously treated DD-LPS whose sarcoma progressed on approved agents. METHODS SEAL was a phase II-III, multicenter, randomized, double-blind, placebo-controlled study. Patients age 12 years or older with advanced DD-LPS who had received two-five lines of therapy were randomly assigned (2:1) to selinexor (60 mg) or placebo twice weekly in 6-week cycles (crossover permitted). The primary end point was progression-free survival (PFS). Patients who received at least one dose of st…
Recensione a So quel che senti. Neuroni specchio arte ed empatia di Lucia Pizzo Russo
2010
Il tema di questo libro è "l'empatia estetica", un costrutto teorico che ha avuto uno sviluppo rigoglioso fra Ottocento e Novecento, e che oggi, grazie ai neuroni specchio ("le cellule del cervello più famose di tutte"), è ritornato di grande attualità. Così, per il fascino del prefisso "neuro", l'empatia si è imposta come un fatto scientifico incontrovertibile. Ma lo è? La gioia e la tristezza sono passioni invisibili? La leggerezza e la pesantezza sono qualità dell'oggetto o del soggetto? Passioni e qualità espressive le percepiamo o le empatizziamo? I neuroni specchio sono il correlato neuronale dell'empatia? Quel che senti si incarna nel tuo corpo o nel mio cervello? Sono queste le doma…
A group invariant Bishop-Phelps theorem
2021
We show that for any Banach space and any compact topological group G ⊂ L ( X ) G\subset L(X) such that the norm of X X is G G -invariant, the set of norm attaining G G -invariant functionals on X X is dense in the set of all G G -invariant functionals on X X , where a mapping f f is called G G -invariant if for every x ∈ X x\in X and every g ∈ G g\in G , f ( g ( x ) ) = f ( x ) f\big (g(x)\big )=f(x) . In contrast, we show also that the analog of Bollobás result does not hold in general. A version of Bollobás and James’ theorems is also presented.
Age-dependent regulation of antioxidant genes by p38α MAPK in the liver
2018
p38α is a redox sensitive MAPK activated by pro-inflammatory cytokines and environmental, genotoxic and endoplasmic reticulum stresses. The aim of this work was to assess whether p38α controls the antioxidant defense in the liver, and if so, to elucidate the mechanism(s) involved and the age-related changes. For this purpose, we used liver-specific p38α-deficient mice at two different ages: young-mice (4 months-old) and old-mice (24 months-old). The liver of young p38α knock-out mice exhibited a decrease in GSH levels and an increase in GSSG/GSH ratio and malondialdehyde levels. However, old mice deficient in p38α had higher hepatic GSH levels and lower GSSG/GSH ratio than young p38α knock-…
“ANALISI DI NUOVI MECCANISMI MOLECOLARI DELLA RISPOSTA IMMUNITARIA INNATA NEL RICCIO DI MARE PARACENTROTUS LIVIDUS”
La risposta immune contro l’invasione dei patogeni è un meccanismo fisiologico presente in tutti gli organismi viventi. Gli animali possiedono recettori che si legano a elementi estranei riconosciuti come non-self che successivamente attivano una risposta cellulare. Il meccanismo di trasduzione del segnale inizia una complessa cascata di reazioni cellulari che conduce alla produzione di molecole effettrici quali le citochine. Alla fine si ha l’eliminazione o l’inattivazione del patogeno. A questo complesso meccanismo prendono parte recettori, molecole antimicrobiche, fattori di trascrizione, ecc… Gli echinodermi rappresentano i più evoluti invertebrati che formano un ponte con i cordati pri…
Dannenšterna nama saglabāšanas vēsture 20.gs. otrajā pusē
2016
Bakalaura darba tēma ir "Dannenšterna nama saglabāšanas vēsture 20.gs otrajā pusē". Dannenšterna nams ir unikāls valsts nozīmes kultūras piemineklis. Neskatoties uz nama vēsturiski nozīmīgo statusu, tā restaurācija un apsaimniekošanajau ilgstoši ir problemātiska. Bakalaura darba mērķis ir izpētīt, kā 20.gs 2.pusē noritēja Dannenšterna nama restaurācijas process un kādam nolūkam bija ēku izmantot. Lai realizētu bakalaura darba mērķi, tika izpētīti un izanalizēti materiāli par kultūras pieminekļu aizsardzību darba tēmas ietvaros, izpētīti arhīvu, preses publikāciju materiāli par Dannenšterna nama saglabāšanas un apsaimniekošanas pasākumiem no 20.gs 2.puses līdz 21.gs sākumam, kā arī izdarīti …
Prehistoric Settlement and Population in the Madonie Mountains. New Data from the Archaeological Survey
2010
The aim of the Madonie research project is to analyse mobility strategies and the use of a mountainous territory by relating geomorphologic features, raw material sources and landscape to the prehistoric settlement. For this purpose we planned an intensive and systematic survey of sample areas, selected on geo-morphological, altimetric and archaeological criteria, correlated to a palaeoenvironmental investigation based on the study of palynological sequence samples coming from wet areas of the Madonie territory and from archaeological deposits. Le projet de recherche sur la Madonie analyse les stratégies de mobilité et l’exploitation du territoire de montagne, en reliant les caractéristique…
Anti-Inflammatory Effects of Nutritionally Relevant Concentrations of Oleuropein and Hydroxytyrosol on Peripheral Blood Mononuclear Cells: An Age-Rel…
2023
: Immunosenescence and inflammaging facilitate the insurgence of chronic diseases. The Mediterranean diet is a non-invasive intervention to improve the chronic low-grade inflammatory status associated with aging. Olive oil oleuropein (OLE) and hydroxytyrosol (HT) demonstrated a controversial modulatory action on inflammation in vitro when tested at concentrations exceeding those detectable in human plasma. We studied the potential anti-inflammatory effects of OLE and HT at nutritionally relevant concentrations on peripheral blood mononuclear cells (PBMCs) as regards cell viability, frequency of leukocyte subsets, and cytokine release, performing an age-focused analysis on two groups of subj…