Search results for "Lua"
showing 10 items of 3286 documents
IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and ov…
2016
Orally administered drugs are subject to a number of barriers impacting bioavailability (Foral), causing challenges during drug and formulation development. Physiologically-based pharmacokinetic (PBPK) modelling can help during drug and formulation development by providing quantitative predictions through a systems approach. The performance of three available PBPK software packages (GI-Sim, Simcyp®, and GastroPlus™) were evaluated by comparing simulated and observed pharmacokinetic (PK) parameters.Since the availability of input parameters was heterogeneous and highly variable, caution is required when interpreting the results of this exercise. Additionally, this prospective simulation exer…
IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysin…
2016
Three Physiologically Based Pharmacokinetic software packages (GI-Sim, Simcyp® Simulator, and GastroPlus™) were evaluated as part of the Innovative Medicine Initiative Oral Biopharmaceutics Tools project (OrBiTo) during a blinded “bottom-up” anticipation of human pharmacokinetics. After data analysis of the predicted vs. measured pharmacokinetics parameters, it was found that oral bioavailability (Foral) was underpredicted for compounds with low permeability, suggesting improper estimates of intestinal surface area, colonic absorption and/or lack of intestinal transporter information. Foral was also underpredicted for acidic compounds, suggesting overestimation of impact of ionisation on pe…
Image-Guided Synthesis Reveals Potent Blood-Brain Barrier Permeable Histone Deacetylase Inhibitors
2014
Recent studies have revealed that several histone deacetylase (HDAC) inhibitors, which are used to study/treat brain diseases, show low blood-brain barrier (BBB) penetration. In addition to low HDAC potency and selectivity observed, poor brain penetrance may account for the high doses needed to achieve therapeutic efficacy. Here we report the development and evaluation of highly potent and blood-brain barrier permeable HDAC inhibitors for CNS applications based on an image-guided approach involving the parallel synthesis and radiolabeling of a series of compounds based on the benzamide HDAC inhibitor, MS-275 as a template. BBB penetration was optimized by rapid carbon-11 labeling and PET im…
Efficacité interne des systèmes éducatifs et évaluation par les résultats
1995
International audience
La profesionalización en la formación de los historiadores del arte a través de las prácticas externas
2007
Este estudio, sobre el sistema de prácticas en empresas e instituciones de los alumnos de Historia del Arte en la universidad española, pone de manifiesto la importancia del tema en la formación e inserción profesional de los egresados, y por ello la necesidad de iniciar un debate ante la reforma del plan de estudios que impulsa el proceso de Espacio Europeo de Educación Superior (EEES). (A)
RESPONSABILITÉ EST PLANIFICATION. OEdipe planificateur de la ville du présent.
2016
Il contributo analizza e individua scenari di sviluppo per una condizione particolarmente sensibile quale quella in cui i grandi valori del patrimonio culturale e paesaggistico si intrecciano con le richiesta di trasformazione. La relazione, quindi, tra la pianificazione territoriale e una visione strategicamente orientata per la valutazione delle risorse ambientali viene individuata come una possibile soluzione alla crescita senza controllo e come risolutore della condizione di conflitto determinato dalla assenza di relazioni tra tutelato e non tutelato. Le document analyse et identifie les scénarios de développement pour une condition particulièrement sensible: les grandes valeurs du pays…
Synthetic evaluation of territorial sustainability : strengths and weaknesses of modeling in the planning process
2017
This thesis work is based on issues aimed at assessing the impacts of planning decisions in the light of the imperatives of sustainable development. Beyond the vagueness that often emerges from this concept, the aim here is to reflect on a better balance to be found between the three fields generally identified as pillars of sustainable development: the economic, the social and the environmental. The objective is part of the following reflection: how to evaluate the impacts of management policies in each of these three pillars, and what conclusions to draw from them? The aim here is to provide answers by assessing the performance of the territories studied in these three pillars of sustaina…
Verifica dell’applicabilità del metodo irriguo sub-superficiale su colture agrumicole e ottimizzazione dell’uso della risorsa idrica
2020
Gli impianti di subirrigazione (SDI), in relazione alla posizione interrata dei gocciolatori permettono la riduzione dei consumi irrigui, garantendo la possibilità di utilizzo di risorse altrimenti non utilizzabili. Tuttavia, i costi di investimento iniziali risultano maggiori di quelli relativi ai tradizionali impianti di microirrigazione e pertanto, diventano economicamente vantaggiosi, se l'efficienza del sistema viene garantita per periodi di almeno 15-20 anni. La SDI, inoltre, permette di ottenere valori elevati di efficienza d’uso dell’acqua, spesso superiori al 90%, se associata ad un monitoraggio continuo dello stato idrico del suolo e della pianta e ad una corretta stima delle esig…
Usability of Programming Languages
2016
Programming languages form the interface between programmers (the users) and the computation that they desire the computer to execute. Although studies exist for some aspects of programming language design (such as conditionals), other aspects have received little or no human factors evaluations. Designers thus have little they can rely on if they want to make new languages highly usable, and users cannot easily chose a language based on usability criteria. This SIG will bring together researchers and practitioners interested in increasing the depth and breadth of studies on the usability of programming languages, and ultimately in improving the usability of future languages. nonPeerReviewed
Usability challenges in digital learning solutions
2015
Usability is a key element in successful software. Ensuring the technical usability of a learning solution enables users to focus on their main task, learning. The purpose of this paper is to demonstrate the results of heuristic usability evaluations of digital learning solutions. Heuristic evaluations were conducted on 24 digital learning solutions from one country (Finland) and two country groups (Asian countries and Spanish speaking countries) concentrating on the usability of the user interface of each evaluated solution. The main results of this study indicate that a few heuristics cover the majority of all usability problems (UPs) observed in learning solutions, but these heuristics c…