Search results for "Lua"
showing 10 items of 3286 documents
La teoría del cambio: una herramienta para la planificación y la evaluación participativa en salud comunitaria
2020
Resumen: Existe un creciente interés por encontrar respuestas innovadoras para evaluar intervenciones complejas en salud pública. En esta nota metodológica, se presenta la teoría del cambio como una herramienta útil para facilitar tanto la planificación como la evaluación de intervenciones en promoción de la salud comunitaria. Una teoría del cambio es una representación visual de cómo funciona un programa o una intervención, en la que se identifican sus diferentes componentes y cómo cada elemento se vincula con otro: cuáles son sus objetivos, los resultados esperados y a través de qué acciones se pretenden alcanzar. Es una herramienta de investigación aplicada a la práctica que se desarroll…
Polypeptides controlling hematopoietic blood cell development and activation
1989
Colony-stimulating factors (CSFs) have entered the clinical arena. Several investigators have explored, in first clinical phase I studies, different routes of administration to define the optimum biological dose, maximum tolerated dose, toxicity, and pharmacokinetics of these reagents. It has been demonstrated that recombinant human (rh) granulocyte-macrophage CSF (GM-CSF) and granulocyte CSF (G-CSF) can be safely administered over a broad dose range to increase number of circulating granulocytes in man. More recently, GM-CSF and G-CSF have been involved in phase Ib/II studies to assess the granulopoietic responses of patients with granulocytopenia due to various underlying disease states i…
Retrospective clinical evaluation of root canal treatment with or without photodynamic therapy for necrotic teeth and teeth subjected to retreatment.
2021
PURPOSE To compare the effect of photodynamic therapy (PDT) as a procedure to complement root canal treatment (RCT), for both primary treatment and retreatment. METHODS This was a retrospective study based on analysis of clinical records. A total of 214 teeth that had undergone RCT on either a primary or retreatment basis, with or without complementary PDT, were evaluated. For 118 teeth that met the previously established inclusion criteria, the time until healing was evaluated. Complementarily, the need for application of calcium hydroxide (CaHy) between visits and the number of visits necessary for completing the treatment were assessed. Data were analyzed using the Mann-Whitney and χ2 te…
<p>Clinical Evaluation of Everolimus in the Treatment of Neuroendocrine Tumors of the Lung: Patient Selection and Special Considerations. A Sys…
2020
Abstract Neuroendocrine tumors (NETs) of the lung are well-differentiated neuroendocrine neoplasms (NENs) with a heterogeneous clinical behaviour. Unlike gastroenteropancreatic NENs where therapeutic armamentarium clearly increased over the last decade, everolimus represented the only clinical practical innovation for lung NET patients over the last years. Therefore, for lung NETs, a multidisciplinary discussion within a dedicated team remains critical for an adequate decision-making. Although the main regulatory authorities considered the everolimus-related evidence is enough to approve the drug in advanced lung NETs, several clinical features deserve to be discussed. In this review, we sy…
Bone marrow evaluation according to the PVSG and WHO criteria in 90 essential thrombocythemia (ET) patients treated with PEG interferon alpha-2b. Pre…
2005
Abstract Ninety ET patients diagnosed according to the PVSG criteria were enrolled in a phase II study (sponsored by the Schering-Plough Company) designed to evaluate the efficacy, safety and tolerability of a two years treatment with PEG Interferon alpha-2 b (PEG Intron). The patients, observed in 16 Italian Centres belonging to the GIMEMA Cooperative Group and judged at high risk, had been previously treated with cytoreductive (97%) and antiplatelet (91%) drugs. At the study start the patients, 60 F and 30 M, mean age 45 years, showed splenomegaly in 22% of cases. The Hematological Response (HR: PLT&lt;500 x109/L) was observed in 64/81 (79%) and 48/55 (87%) of the patients on PEG Intr…
The Potential Use of Resveratrol for Cancer Prevention.
2019
In addition to the traditional treatments of cancer and cancer prevention, the use of natural compounds, especially those found in food, should be considered. To clarify if resveratrol has the potential for cancer prevention and the possibility of use in therapy, the following must be taken into account: data from epidemiology, clinical protocol (case and control), preclinical studies (lab animals), use of established cell lines as models of cancer cells, test tube assays (enzymes activities), and requirements of nanotechnologies in order to discover new drugs to fight cancer. From this perspective and future expected advances, more information is needed such as improved efficacy, methods o…
Revista electrónica de investigación y evaluación educativa
2020
Título, resumen y palabras clave en español e inglés Resumen basado en el de la publicación Disponible la versión en inglés Se muestra el proceso llevado a cabo en el diseño y validación de un cuestionario que evalúa los comportamientos phubbing y los efectos que producen en las vidas de las personas. Estas conductas pueden definirse como el acto de ignorar a las personas en un entorno social mirando el teléfono en lugar de prestar atención a la conversación (Blachnio y Przepiorka, 2019). Mediante el método de redes semánticas naturales se describe el procedimiento seguido para la creación del instrumento con la colaboración de un grupo de personas expertas. Se presentan la validación de co…
Campus virtuales : revista científica iberoamericana de tecnología educativa
2019
Resumen basado en el de la publicación Resumen en inglés Se presentan los resultados de un estudio descriptivo cuyos objetivos principales eran conocer los portales institucionales de dos países (Argentina y Brasil), analizar la oferta de materiales didácticos digitales dirigidos a la etapa de educación primaria y realizar una serie de recomendaciones o propuestas para modificar las prácticas docentes hacia un modelo de enseñanza mediada por tecnología. Los resultados muestran la existencia de portales institucionales que se consideran una de las principales fuentes de materiales didácticos digitales utilizados por los docentes para acceder a recursos útiles en la escuela. Se concluye que e…
The Subjective Social Value of Education Construct: CrossValidation between School and University Teachers
2016
La Educación posee un valor social evidente que puede presentarse mediante indicadores de evaluación socio-educativos. Si bien la relación entre contexto escolar y rendimiento es evidente en diversos países, esta relación va perdiendo consistencia en los últimos años; ya que aparecen sectores estudiantiles que superan las predicciones académicas esperadas. Para ello, se estudia el Valor Social Subjetivo de la Educación en función de dos grupos docentes –escuela y universidad–. La metodología es complementaria a través de comités de expertos/as y validación cruzada de constructo. Se realizan análisis sobre dos escalas –relevancia y susceptibilidad de cambio– y entre dos muestras diferenciada…
Desirable properties of performance indicators for assessing interactive evolutionary multiobjective optimization methods
2022
Interactive methods support decision makers in finding the most preferred solution in multiobjective optimization problems. They iteratively incorporate the decision maker's preference information to find the best balance among conflicting objectives. Several interactive methods have been developed in the literature. However, choosing the most suitable interactive method for a given problem can prove challenging and appropriate indicators are needed to compare interactive methods. Some indicators exist for a priori methods, where preferences are provided at the beginning of the solution process. We present some numerical experiments that illustrate why these indicators are not suitable for …