Search results for "Lua"

Los 'think-tanks' y los 'neocons' / 1

2008

Immunological and immunogenetic markers in sporadic Alzheimer’s disease

2006

Background: Common polymorphisms of genes controlling inflammation-modulating cytokines and acute-phase proteins which play important roles in the pathogenesis of Alzheimer''s disease (AD) have been shown to be associated with AD. Aims: The immunological and immunogenetic markers potentially useful for the AD risk evaluation and diagnosis are briefly reviewed. Conclusion: The state-of-the-art of immunological and immunogenetic markers of AD indicates that new tools and strategies are necessary to identify gene products useful as diagnostic tools.

Associations of socio-economic position and disability among older women in Britain and Jyväskylä, Finland

2005

The aim was to compare the pattern of associations in measures of socio-economic position and disability among British and Finnish older women. In Britain data from the British Women's Heart and Health Study was used. Women from 23 towns took part in a nurse-assessed medical examination and postal questionnaire (n = 4286). In Finland, data from the Evergreen study was used. Eight hundred and four women from the city of Jyväskylä were interviewed at home. Socio-economic position was measured according to social class in childhood, education, use of a car, home ownership and previous occupation. Disability measures included questions on difficulties in washing/dressing and climbing stairs. Lo…

Coimpairments as Predictors of Severe Walking Disability in Older Women

2001

OBJECTIVE: Severe disabilities are common among older people who have impairments in a range of physiologic systems. It is not known, however, whether the presence of multiple impairments, or coimpairments, is associated with increased risk of developing new disability. The aim of this study was to determine the combined effects of two impairments, decreased knee-extension strength and poor standing balance, on the risk of developing severe walking disability among older, moderately-to-severely disabled women who did not have severe walking disability at baseline. DESIGN: The Women's Health and Aging Study is a 3-year prospective study with 6 semi-annual follow-up data-collection rounds fol…

Fingolimod as a Treatment in Neurologic Disorders Beyond Multiple Sclerosis

2020

Abstract Fingolimod is an approved treatment for relapsing–remitting multiple sclerosis (MS), and its properties in different pathways have raised interest in therapy research for other neurodegenerative diseases. Fingolimod is an agonist of sphingosine-1-phosphate (S1P) receptors. Its main pharmacologic effect is immunomodulation by lymphocyte homing, thereby reducing the numbers of T and B cells in circulation. Because of the ubiquitous expression of S1P receptors, other effects have also been described. Here, we review preclinical experiments evaluating the effects of treatment with fingolimod in neurodegenerative diseases other than MS, such as Alzheimer’s disease or epilepsy. Fingolimo…

Importance of Personality for Objective and Subjective-Physical Health in Older Men and Women

2020

Objective and subjective health generally have a positive relationship, although their association may be moderated by factors such as gender and personality. We aimed to analyze the association between personality and objective (metabolic syndrome (MetS)) and subjective-physical health in older men and women. For this purpose, in 138 participants (53.6% women, Mage = 66.85), neuroticism, conscientiousness, extraversion, openness, and agreeableness (NEO Five Factor Inventory), subjective-physical health (Short Form Health Survey, SF-36), and MetS (employing waist circumference, blood pressure, triglycerides, high-density lipoprotein cholesterol, and glycated hemoglobin) were assessed. Logis…

Examining Mechanisms of Personality Maturation

2012

Individuals are expected to mature with increasing age, but it is not yet fully understood which factors contribute to this maturation process. Using data of a representative sample of Germans ( N = 14,718) who gave information about their Big Five personality traits twice over a period of 4 years, the authors identified satisfaction with life, which was reported yearly, as an important variable for explaining mechanisms and interindividual differences in personality maturation. Dual latent change models suggest that more satisfied (compared to less satisfied) individuals experience more positive changes in Emotional Stability, Agreeableness, and Conscientiousness and that positive changes…

Agricultural quality products for territorial evaluation and tourism development in Sicily: the Pantelleria case

2010

The Agri-Food system is determined and conditioned by the effects of great phenomena, strictly related to territorial, environmental, social, political and economical aspects. Thus, agriculture has to carry out complex roles within the multi-functionality framework throughout production of healthy products, safeguard and protection of environment and territory, preservation and safeguard of bio-diversity, and by supplying goods and services to public, integrating with industry and agrifood distribution. Within such scenery, developed Countries, and in particular those of the EU, carry out strategies in order to adjust to new agrifood market conditions, and to respond to citizens-consumers i…

Territoires et effets sur les conditions de vie étudiante : étude de cas du dispositif de l’Aide à l’Installation dans un Logement pour les Étudiants…

2020

International audience; L’immolation d’un étudiant précaire à Lyon en automne dernier a ravivé le débat sur les conditions de vie étudiante en France. Dans un contexte de mise en concurrence des villes étudiantes, l’échelle locale est de plus en plus impliquée dans l’amélioration des conditions de vie étudiante et travaille à rendre leur territoire plus attractif pour les étudiants. Un focus est fait sur le dispositif d’Aide à l’Installation dans un Logement pour les Étudiants de la ville de Paris, dispositif qui veut favoriser la mixité sociale étudiante. Une évaluation quantitative du dispositif a été faite à l’aune de la théorie des capabilités. Le dispositif a ainsi augmenté le champ de…

Penser la ville durable : positionner la modélisation et l’évaluation des territoires dans les processus d’aménagement

2015

National audience; Les politiques d’aménagement du territoire sont guidées depuis deux décennies par les objectifs du développement durable. Én¬oncé dans le rapport de G.H. Brundtland (1987) réalisé pour le compte des Nations-Unies, l’expression « développement du¬rable » définit en effet un « développe¬ment qui répond au besoin du présent sans compromettre la capacité des généra¬tions futures à satisfaire leurs propres be¬soins ». Trois sphères distinctes mais qui se chevauchent sont identifiées, dans les¬quelles les principes de développement du¬rable doivent être appliqués : l’économique, le social et l’environnemental, la combi¬naison des trois faisant théoriquement at¬teindre le niveau…