Search results for "Lung"

Spins and magnetic moments of 58;60;62;64Mn ground states and isomers

2015

The odd-odd 54;56;58;60;62;64Mn isotopes (Z = 25) were studied using bunched-beam collinear laser spectroscopy at ISOLDE, CERN. From the measured hyperfine spectra the spins and magnetic moments of Mn isotopes up to N = 39 were extracted. The previous tentative ground state spin assignments of 58;60;62;64Mn are now firmly determined to be I = 1 along with an I = 4 assignment for the isomeric states in 58;60;62Mn. The I = 1 magnetic moments show a decreasing trend with increasing neutron number while the I = 4 moments remain quite constant between N = 33 and N = 37. The results are compared to large-scale shell-model calculations using the GXPF1A and LNPS effective interactions. The excellen…

High-resolution laser spectroscopy of $^{27-32}$Al

2020

Physical review / C 103(1), 014318 (2021). doi:10.1103/PhysRevC.103.014318

Reporting in Conflict Zones in Pakistan: Risks and Challenges for Fixers

2020

As a backbone of reporting in war and conflicts, fixers offer essential assistance to the foreign correspondent in conflict zones, also in Pakistan. With valuable local knowledge and contacts, fixers can arrange travel to secure entry of foreign correspondents into conflict zones in addition to securing interviews with otherwise unattainable figures, while offering reliable translation services. Pakistani media, despite being one of the largest and most developed in South Asia, remains under the strict control of powerful military establishment and government, while seeming to mirror the overarching government sentiment with a distinct lack of research-based news. Challenging this state of …

Parathyroid Hormone Related Protein (PTHrP)-Associated Molecular Signatures in Tissue Differentiation and Non-Tumoral Diseases

2023

A Historical Analysis of Media Practices and Technologies in Protest Movements : A Review of Crisis and Critique by Anne Kaun

2017

Dr. Anne Kaun’s book, <em>Crisis and Critique: A Brief History of Media Participation in Times of Crisis</em> (London: Zed Books, 2016, 131 pp., ISBN: 978-1-78360-736-5), is a concise but comprehensive analysis of the changing media practices and technologies in protest movements. The book overviews the topic within the context of major economic crises and scrutinises three richly detailed case studies in the United States: (a) the unemployed workers’ movement during the Great Depression in the 1930s, (b) the tenants’ rent strike movement of the early 1970s, and (c) the Occupy Wall Street movement following the Great Recession of 2008. Kaun begins her book with an introduction t…

Le dépôt de Quitteur (Haute-Saône) et les dépôts de bronzes en contexte d’habitat au Bronze final

2020

Le petit dépôt de bronzes découvert à Quitteur (commune de Beaujeu-Saint-Vallier-Pierrejux et Quitteur ; Haute-Saône - France), sur une moyenne terrasse de la Saône, est composé de trente-deux objets comprenant un assortiment d’éléments de parures (boutons à bélière, pendeloque, anneaux) associés à un couteau à manche massif et une armature de flèche. Le lieu de découverte du dépôt, dans l’espace occupé par les vestiges d’un habitat contemporain du RSFO, s’écarte de la majorité des dépôts de bronzes isolés comme l’archéologie les perçoit habituellement. À l’aide de quelques comparaisons géographiquement proches, il est alors permis de nous interroger sur le caractère apparemment inhabituel …

Localization of Viral Epitope-Specific CD8 T Cells during Cytomegalovirus Latency in the Lungs and Recruitment to Lung Parenchyma by Airway Challenge…

2021

Interstitial pneumonia is a life-threatening clinical manifestation of cytomegalovirus infection in recipients of hematopoietic cell transplantation (HCT). The mouse model of experimental HCT and infection with murine cytomegalovirus revealed that reconstitution of virus-specific CD8+ T cells is critical for resolving productive lung infection. CD8+ T-cell infiltrates persisted in the lungs after the establishment of latent infection. A subset defined by the phenotype KLRG1+CD62L− expanded over time, a phenomenon known as memory inflation (MI). Here we studied the localization of these inflationary T effector-memory cells (iTEM) by comparing their frequencies in the intravascular and transm…

The Metabolic Sensor GPR43 Receptor Plays a Role in the Control of Klebsiella pneumoniae Infection in the Lung

2018

Pneumonia is one of the leading causes of death and mortality worldwide. The inflammatory responses that follow respiratory infections are protective leading to pathogen clearance but can also be deleterious if unregulated. The microbiota is known to be an important protective barrier against infections, mediating both direct inhibitory effects against the potential pathogen and also regulating the immune responses contributing to a proper clearance of the pathogen and return to homeostasis. GPR43 is one receptor for acetate, a microbiota metabolite shown to induce and to regulate important immune functions. Here, we addressed the role of GPR43 signaling during pulmonary bacterial infection…

Is the Complement Protein C1q a Pro- or Anti-tumorigenic Factor? Bioinformatics Analysis Involving Human Carcinomas

2019

C1q is the first subcomponent of the classical pathway of the complement system and belongs to the C1q/Tumor Necrosis Factor superfamily. C1q can perform a diverse range of immune and non-immune functions in a complement-dependent as well as -independent manner. Being a pattern recognition molecule of the innate immunity, C1q can recognize a number of self, non-self and altered-self ligands and bring about effector mechanisms designed to clear pathogens via opsonisation and inflammatory response. C1q is locally synthesized by macrophages and dendritic cells, and thus, can get involved in a range of biological processes, such as angiogenesis and tissue remodeling, immune modulation, and immu…

CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis

2019

Abstract Background and Aims: In immunosuppressed individuals Aspergillus (A.) fumigatus is a frequent cause of invasive pulmonary aspergillosis (IPA) which is highly associated with relevant morbidity and mortality. Moreover, it often occurs in patients suffering from leukocyte-adhesion deficiency type 1 (LAD1) which is triggered by a functional loss of CD18 in ß2 integrin receptors as these receptors consist of an alpha subunit (CD11a-CD11d) and CD18 as the common beta subunit. ß2 integrin receptors are differentially expressed by leukocytes, and are required for cell-cell interaction, transendothelial migration, uptake of opsonized pathogens, and cell signaling processes. Here, we asked …