Search results for "Lung"

Single and Synergistic Effects of Type 2 Cytokines on Eosinophils and Asthma Hallmarks

2020

Abstract The type 2 cytokines IL-5, IL-13, and IL-4 play an important role in the induction and progression of asthma. According to the Global Initiative for Asthma guidelines, blood eosinophil numbers are one marker that helps to guide treatment decisions in patients suffering from severe forms of asthma. Effects of type 2 cytokines were analyzed, alone or in combination, on eosinophils in blood and other compartments and on the development of asthma symptoms. C57BL/6 mice received a single intranasal application of equimolar amounts of IL-5, IL-13, and IL-4, alone or in combination. Numbers, activation state, and migratory behavior of eosinophils in bone marrow (BM), blood, lung, and bron…

Spontaneous labour at term is associated with fetal monocyte activation.

1999

SUMMARYThe aetiology of both term and preterm labour remains incompletely understood. Maternal infectious diseases as well as intra-uterine infections were shown to be a well established cause of uncontrollable preterm delivery, indicating that inflammatory reactions, regulated by maternal immunecompetent cells, are implicated in labour-promoting mechanisms. To investigate the possibility that the activation of the fetal immune system may be involved in labour induction, we examined cytokine production patterns of different cord blood cell populations obtained from neonates after spontaneous onset of normal term labour and vaginal delivery (n = 25), vaginal delivery but induced term labour …

Observation of the decay KS→π+π−e+e−

2000

Abstract We present the first observation of the decay KS→π+π−e+e− based upon the data collected in 1998 by the NA48 experiment at CERN. We have identified a clean sample of 56 events with negligible background contamination. Using KL→π+π−π0D decays as normalization sample, the branching ratio is measured to be BR(KS→π+π−e+e−)=[4.5±0.7(stat)±0.4(syst)]×10−5. This result is in good agreement with the theoretical expectations from the mechanism of inner bremsstrahlung.

Poly(I:C) and CpG-ODN combined aerosolization to treat lung metastases and counter the immunosuppressive microenvironment.

2015

The immunostimulatory ability of synthetic oligonucleotides containing CpG motifs (CpG-ODN), agonists of Toll-like receptor 9 (TLR9), can be harnessed to promote antitumor immunity by their application at the tumor site to stimulate local activation of innate immunity; however, particularly in the lung, tumor-associated immunosuppression can subvert such antitumor innate immune responses. To locally maintain continuous activation of innate subpopulations while inhibiting immunosuppressive cells, we evaluated aerosol delivery CpG-ODN combined with Poly(I:C), a TLR3 agonist able to convert tumor-supporting macrophages to tumoricidal effectors, in the treatment of B16 melanoma lung metastases …

STUDY OF LARGE PELAGIC FISH LIFE-HISTORY TRAITS IN THE CENTRAL MEDITERRANEAN SEA AND PROJECTION UNDER FUTURE CLIMATE CHANGE SCENARIOS

2022

One of the most sensitive life periods for each species is the first life stages (larval and juvenile). The survival rates of pelagic fish larvae in these phases are usually very low and subject to fluctuations, consequently affecting the recruitment of new generations. From historical Tuna landing data, the stock's abundance is fluctuating, especially for Atlantic Bluefin Tuna (ABT) (Thunnus thynnus, Linnaeus, 1758) Eastern stock. It is the largest Mediterranean Tuna and one of the most expensive species in the world. Some studies hypothesized that the fluctuations are dictated by environmental factors, particularly in the early life stages. Therefore, it appears necessary to better unders…

Unveiling the Relationship Between Sea Surface Hydrographic Patterns and Tuna Larval Distribution in the Central Mediterranean Sea

2021

Thunnus thynnus (Atlantic bluefin tuna, ABT) and other tuna species reproduce in the Mediterranean Sea during the summer period. Despite the Central Mediterranean Sea, the Strait of Sicily in particular, being a key spawning site for many tuna species, little is known on the effects of oceanographic variability on their larval distribution in this area. The abundance and presence-absence of larval specimens for three tuna species (ABT, bullet tuna and albacore) were modeled in order to examine their relationships with environmental factors, by analysing historical in situ information collected during seven annual surveys (2010–2016). The results revealed that most tuna larvae for the three …

Evaluation of radiological findings with COVID-19 lung lesions in Latvia in the view of artificial intelligence and radiologist

2022

Pēc Pasaules Veselības organizācijas datiem kopš pandēmijas sākuma kopējais ar Covid-19 saslimušo cilvēku skaits pārsniedz 500 miljonus. Mākslīgais intelekts (MI) paver plašas iespējas Covid-19 infekcijas izraisīto plaušu bojājumu diagnostikā, kas var uzlabot un atvieglojot radiologa darbu veicinot gan izmeklējuma specifitātes, gan sensitivitātes izvērtēšanas iespējas. Šī pētījuma galvenais mērķis bija salīdzināt MI un radiologa atradnes precizitāti Covid-19 radītā plaušu bojājuma izvērtēšanā un noteikt interpretācijas ierobežojumus un priekšrocības klīniskā kontekstā. Savukārt darba uzdevumi bija iepazīties un apkopot datus ar jaunāko literatūru par MI pielietošanas iespējām medicīnā. Apko…

"Incidence of different KRAS mutation in non-small cell lung cancer (NSCLC) patients, TAILOR STUDY

2011

Shape staggering of midshell mercury isotopes from in-source laser spectroscopy compared with density-functional-theory and Monte Carlo shell-model c…

2019

Neutron-deficient Hg177-185 isotopes were studied using in-source laser resonance-ionization spectroscopy at the CERN-ISOLDE radioactive ion-beam facility in an experiment combining different detection methods tailored to the studied isotopes. These include either α-decay tagging or multireflection time-of-flight gating for isotope identification. The endpoint of the odd-even nuclear shape staggering in mercury was observed directly by measuring for the first time the isotope shifts and hyperfine structures of Hg177-180. Changes in the mean-square charge radii for all mentioned isotopes, magnetic dipole, and electric quadrupole moments of the odd-A isotopes and arguments in favor of I=7/2 s…

The role of SAXS and molecular simulations in 3D structure elucidation of a DNA aptamer against lung cancer

2021

Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as synthetic analogs of antibodies and bind to a target molecule with high specificity. Aptamer affinity entirely depends on its tertiary structure and charge distribution. Therefore, length and structure optimization are essential for increasing aptamer specificity and affinity. Here, we present a general optimization procedure for finding the most populated atomistic structures of DNA aptamers. Based on the existed aptamer LC-18 for lung adenocarcinoma, a new truncated LC-18 (LC-18t) aptamer LC-18t was developed. A three-dimensional (3D) shape of LC-18t was reported based on small-angle X-ray scattering…