Search results for "Lymphatic"

showing 10 items of 1179 documents

Persistence of Human Bocavirus 1 in Tonsillar Germinal Centers and Antibody-Dependent Enhancement of Infection

2021

Human bocavirus 1 (HBoV1), a common pediatric respiratory pathogen, can persist in airway secretions for months hampering diagnosis. It also persists in tonsils, providing potential reservoirs for airway shedding, with the exact location, host cell types, and virus activity unknown.

NASOPHARYNXviruksetPalatine TonsilFc receptorCHILDRENvirus persistenceMonocytesHuman bocavirusCONGENITAL INSENSITIVITYBokavirusChildviruspersistenssi11832 Microbiology and virology0303 health sciencesB-LymphocytesbiologyHuman bocavirusvasta-aineetDENGUE-VIRUS-INFECTIONrespiratory systemMiddle AgedQR1-5023. Good healthLymphatic systemB-CELLSChild PreschoolAntibodyCELL-LINE U937HUMAN PARVOVIRUSResearch ArticleAdultAdolescentEndosomesMicrobiologyinfektiotVirusHost-Microbe BiologyParvoviridae Infections03 medical and health sciencesYoung AdultImmune systemnielurisaVirologytonsilsHumansAntibody-dependent enhancementRESPIRATORY VIRUSESparvovirukset030304 developmental biologyAgedRECEPTOR030306 microbiologyparvovirusInfant NewbornGerminal centerInfantbiology.organism_classificationGerminal CenterAntibody-Dependent Enhancementrespiratory tract diseasesgerminal centerImmunologyDNA Viralbiology.protein1182 Biochemistry cell and molecular biology3111 Biomedicinein situ hybridizationADEB-soluTRACTmBio
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Combined Targeting of the Menin-MLL1 Chromatin Complex and FLT3 As a Novel Therapeutic Concept Against NPM1 Mutant or MLL-Rearranged AML with Mutated…

2019

NPM1mutant (NPM1mut) and MLL1-rearranged (MLL-r) acute myeloid leukemias (AMLs) exhibit aberrant expression of HOX and MEIS1 transcription factors and commonly harbor an activating mutation in the receptor tyrosine kinase FLT3. Pharmacologic inhibition of the menin-MLL1 complex reverses leukemogenic gene expression including MEIS1 and FLT3 and represents a therapeutic opportunity for the treatment of these leukemias. Here, we investigate the contribution of the menin-MLL1 complex to leukemic FLT3 signaling and assess the therapeutic potential of dual menin-MLL1 and FLT3 targeting. First, we performed RNA sequencing to delineate transcriptional changes associated with menin-MLL1 inhibition (…

NPM1ImmunologyPonatinibCell BiologyHematologyBiologymedicine.diseaseBiochemistrychemistry.chemical_compoundLeukemiachemistryhemic and lymphatic diseasesGene expressionCancer researchmedicineEctopic expressionGrowth inhibitionCrenolanibQuizartinibBlood
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Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition

2020

Abstract The interaction of menin (MEN1) and MLL (MLL1, KMT2A) is a dependency and provides a potential opportunity for treatment of NPM1-mutant (NPM1mut) and MLL-rearranged (MLL-r) leukemias. Concomitant activating driver mutations in the gene encoding the tyrosine kinase FLT3 occur in both leukemias and are particularly common in the NPM1mut subtype. In this study, transcriptional profiling after pharmacological inhibition of the menin-MLL complex revealed specific changes in gene expression, with downregulation of the MEIS1 transcription factor and its transcriptional target gene FLT3 being the most pronounced. Combining menin-MLL inhibition with specific small-molecule kinase inhibitors…

NPM1Transcription GeneticImmunologyApoptosisBiochemistryMiceRandom AllocationMice Inbred NODCell Line TumorProto-Oncogene Proteinshemic and lymphatic diseasesAntineoplastic Combined Chemotherapy ProtocolsGene expressionmedicineAnimalsHumansMEN1PhosphorylationMyeloid Ecotropic Viral Integration Site 1 ProteinProtein Kinase InhibitorsneoplasmsbiologyGene Expression Regulation LeukemicKinaseNuclear ProteinsMyeloid leukemiaDrug SynergismHistone-Lysine N-MethyltransferaseCell BiologyHematologymedicine.diseaseCoculture TechniquesNeoplasm ProteinsLeukemia Myeloid AcuteLeukemiaKMT2Afms-Like Tyrosine Kinase 3biology.proteinCancer researchNucleophosminProtein Processing Post-TranslationalTyrosine kinaseMyeloid-Lymphoid Leukemia ProteinBlood
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High frequency of subclonal ALK mutations in high risk neuroblastoma patients. A SIOPEN study

2015

Introduction: In neuroblastoma (NB), activating ALK receptor tyrosine kinase point mutations are detected in 8–10% at diagnosis using conventional sequencing. To determine the potential occurrence and the prognostic impact of ALK mutations in a series of high risk NB patients we studied ALK variation frequencies using targeted deep sequencing in samples of patients enrolled in the SIOPEN HR-NBL01 study

NeuroblastomaALKhemic and lymphatic diseasesHigh RiskSIOPENDoenças Genéticas
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ChemInform Abstract: Synthesis and Antineoplastic Activity of New 4-Diazopyrazole Derivatives.

2010

Several new 4-diazopyrazole derivatives were synthesized by reaction of 1-(R-substituted)phenyl-3-methyl-5-benzamidopyrazoles with a sevenfold excess of nitrous acid in acetic media. The compounds were tested at 20 microM concentration for their antineoplastic activity in vitro against Raji (human Burkitt lymphoma), K562 (human chronic myelogenous leukemia) and U937 (human histiocytic lymphoma) cell lines. They showed a percent of growth inhibition in the range 23.4-100%.

Nitrous acidChemistryHistiocytic lymphomaStereochemistryGeneral Medicinemedicine.diseaseMolecular biologyIn vitroLymphomachemistry.chemical_compoundCell culturehemic and lymphatic diseasesmedicineGrowth inhibitionChronic myelogenous leukemiaK562 cellsChemInform
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Proteomic Profile Study of Chronic Lymphocytic Leukemia-B Patients with IGVH and BCL6 Mutated or Unmutated Genes.

2004

Abstract Introduction: Chronic lymphocytic leukemia B (CLL-B) is the most frequent chronic lymphoproliferative disorder in western countries. The majority of patients are diagnosed in incipient Binet stage A. Some prognostic factors have been identified, as mutations in the genes coding for immunoglobulin variable regions (IgVH). Complementary somatic mutations in the BCL6 gene have been observed in 25% of CLL-B patients, although its clinical relevance remains unclear. Objective: To identify molecular markers of different patient groups of lymphoproliferative disorder through analysis of their proteomic profiles. Material and Methods: 15 samples of peripheral blood lymphocytes B from Binet…

NucleophosminProteomic ProfileProteomic ProfilingChronic lymphocytic leukemiaImmunologyCell BiologyHematologyBiologyBCL6medicine.diseaseBiochemistryMolecular biologyLymphocyte cytosolic protein 2hemic and lymphatic diseasesbiology.proteinmedicineAntibodyGeneBlood
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Seawater carbonate chemistry and carbon sources of mussel shell carbonate

2018

Ocean acidification and warming is widely reported to affect the ability of marine bivalves to calcify, but little is known about the underlying mechanisms. In particular, the response of their calcifying fluid carbonate chemistry to changing seawater carbonate chemistry remains poorly understood. The present study deciphers sources of the dissolved inorganic carbon (DIC) in the calcifying fluid of the blue mussel (Mytilus edulis) reared at two pH (8.1 and 7.7) and temperature (16 and 22 °C) levels for five weeks. Stable carbon isotopic ratios of seawater DIC, mussel soft tissues and shells were measured to determine the relative contribution of seawater DIC and metabolically generated carb…

Ocean Acidification International Coordination Centre (OA-ICC)TemperateRegistration number of speciesSalinityMytilus edulisinorganicAlkalinityExperimentTemperature waterCarbon inorganic dissolvedhemic and lymphatic diseasesCalculated using seacarb after Nisumaa et al 2010PercentageAragonite saturation stateNorth Pacificδ13C dissolved inorganic carbon standard deviationAlkalinity totalSalinity standard errortotalpHTemperaturePartial pressure of carbon dioxide (water) at sea surface temperature (wet air) standard errordissolvedLaboratory experimentCarbonate ionPartial pressure of carbon dioxide (water) at sea surface temperature (wet air)standard errorContainers and aquaria 20 1000 L or 1 m 2δ13C dissolved inorganic carbonEarth System Researchδ13CContainers and aquaria (20-1000 L or &lt; 1 m**2)standard deviationUniform resource locator link to referencecirculatory and respiratory physiologyCalcite saturation statewaterContainers and aquaria (20-1000 L or < 1 m**2)BenthosAlkalinity total standard errorUniform resource locator/link to referenceOcean Acidification International Coordination Centre OA ICCAnimaliaTypeBicarbonate ionTemperature water standard errorCalculated using seacarb after Nisumaa et al. (2010)SpeciespH standard errorCalcite saturation state standard errorCarbonate system computation flagdissolved inorganic carbonFugacity of carbon dioxide (water) at sea surface temperature (wet air)CarbonBiomass/Abundance/Elemental compositionPartial pressure of carbon dioxide water at sea surface temperature wet airCarbon dioxideMolluscaSingle speciesFugacity of carbon dioxide water at sea surface temperature wet airBenthic animalsδ13C standard deviationBiomass Abundance Elemental compositionCoast and continental shelf
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Prognostic Impact of Mutant to Wild-Type Ratio and Insertion Site in Acute Myeloid Leukemia with FLT3 Internal Tandem Duplication

2012

Abstract Abstract 785 Background: FLT3 internal tandem duplications (FLT3-ITD) occur in about 25% of acute myeloid leukemia (AML), are associated with cooperating gene mutations (NPM1, DNMT3A), and confer an adverse prognosis. Several studies have indicated that the unfavorable impact of FLT3-ITD is influenced by a number of factors, such as the mutant to wild-type ratio (allelic ratio), insertion site of FLT3-ITD in the beta1 sheet of the tyrosine kinase domain 1, and the molecular background of cooperating mutations. Aims: To evaluate the relative impact of FLT3-ITD allelic ratio and insertion site, as well as cooperating genetic lesions on prognosis and treatment decision making in a lar…

OncologyAcute promyelocytic leukemiaFLT3 Internal Tandem Duplicationmedicine.medical_specialtyNPM1business.industrymedicine.medical_treatmentImmunologyMyeloid leukemiaCell BiologyHematologyHematopoietic stem cell transplantationGene mutationmedicine.diseaseBiochemistrySurgeryQuartilehemic and lymphatic diseasesInternal medicinemedicinebusinesspsychological phenomena and processesNeoadjuvant therapyBlood
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Deep MRD profiling defines outcome and unveils different modes of treatment resistance in standard- and high-risk myeloma

2021

PETHEMA/GEM Cooperative Group.

OncologyAdultBoron CompoundsMalemedicine.medical_specialtyNeoplasm ResidualPhysics::Instrumentation and DetectorsClinical Trials and ObservationsImmunologyPatient subgroupsGlycineDrug resistanceBiochemistryDexamethasoneBortezomibhemic and lymphatic diseasesInternal medicineAntineoplastic Combined Chemotherapy ProtocolsmedicineNeoplasmHumansProgression-free survivalTreatment resistanceLenalidomideComplete responseMultiple myelomaAgedChromosome AberrationsLymphoid Neoplasiabusiness.industryCell BiologyHematologyMiddle Agedmedicine.diseaseFlow CytometryProgression-Free Survivalbody regionsClinical trialTreatment OutcomeDrug Resistance NeoplasmFemalebusinessMultiple Myeloma
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Assessing the impact of CMF-like/Anthracycline-based/Anthracycline-Taxane-based/dose-dense chemotherapy in dependency of positive axillary lymph node…

2014

Abstract Aim Adjuvant chemotherapy has changed dramatically in the last decades. Anthracycline-/Taxane-based and dose-dense chemotherapy regimens improved survival in node positive breast cancer. This study tries to answer the following questions: (1)Are there differences in survival dependent on chemotherapy regimens in stratified by number of positive lymph nodes/grading (G)/hormone receptor-status (HR)/T-stage? (2)Is it possible to attribute these effects to chemotherapy by only investigating patients who received 100% guideline-conform surgery, radiotherapy and endocrine therapy? Methods This is a German multi-centre (17 participating hospitals all certified as breast cancer centres) re…

OncologyAdultBridged-Ring CompoundsCancer Researchmedicine.medical_specialtyNeoplasms Hormone-DependentAxillary lymph nodesAnthracyclineDose-dense chemotherapyReceptor ErbB-2medicine.medical_treatmentBreast NeoplasmsDisease-Free SurvivalYoung AdultBreast cancerInternal medicineAntineoplastic Combined Chemotherapy ProtocolsMedicineHumansAnthracyclinesAgedRetrospective StudiesAged 80 and overChemotherapyAnalysis of VarianceTaxanebusiness.industryRetrospective cohort studyMiddle Agedmedicine.diseaseSurgeryRadiation therapymedicine.anatomical_structureTreatment OutcomeOncologyChemotherapy AdjuvantLymphatic MetastasisPractice Guidelines as TopicFemaleTaxoidsGuideline AdherencebusinessEuropean journal of cancer (Oxford, England : 1990)
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