Search results for "Lytic"

showing 10 items of 11146 documents

High Biological Value Compounds Extraction from Citrus Waste with Non-Conventional Methods.

2020

Citrus fruits are extensively grown and much consumed around the world. Eighteen percent of total citrus cultivars are destined for industrial processes, and as a consequence, large amounts of waste are generated. Citrus waste is a potential source of high biological value compounds, which can be used in the food, pharmaceutical, and cosmetic industries but whose final disposal may pose a problem due to economic and environmental factors. At the same time, the emerging need to reduce the environmental impact of citrus waste and its responsible management has increased. For these reasons, the study of the use of non-conventional methods to extract high biological value compounds such as caro…

2019-20 coronavirus outbreakHealth (social science)Plant ScienceReviewUltrasound assistedlcsh:Chemical technology01 natural sciencesHealth Professions (miscellaneous)MicrobiologyMicrowave assisted0404 agricultural biotechnologynon-conventional methodsPotential sourcelcsh:TP1-1185010401 analytical chemistryExtraction (chemistry)Supercritical fluid extractionfood and beveragesWater extractionBiological value04 agricultural and veterinary sciencesPulp and paper industry040401 food science0104 chemical scienceshigh-biological-value compoundsextractionEnvironmental sciencecitrus wasteFood ScienceFoods (Basel, Switzerland)
researchProduct

Big data analytics in healthcare: a systematic literature review

2020

The current study performs a systematic literature review (SLR) to synthesise prior research on the  applicability of big data analytics (BDA) in healthcare. The SLR examines the outcomes of 41 stu...

2019-20 coronavirus outbreakInformation Systems and ManagementCoronavirus disease 2019 (COVID-19)Computer sciencebusiness.industrySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)05 social sciencesBig data02 engineering and technologyData scienceHealth informaticsComputer Science ApplicationsSystematic reviewAnalytics0502 economics and businessHealth care0202 electrical engineering electronic engineering information engineering020201 artificial intelligence & image processingbusiness050203 business & managementEnterprise Information Systems
researchProduct

Web searches for anxiolytic drugs during the COVID-19 outbreak in the USA

2021

Several lines of evidence attest that the ongoing coronavirus disease 2019 (COVID-19) pandemic is accompanied by a vast array of physiological problems in the community.1 Since the emergence or magnification of anxiety disorders in the general population has also been suggested during the COVID-19 outbreak,2 we aimed to provide further insights on this matter by performing an electronic search in Google Trends (Google Inc, Mountain View, CA, USA), using the terms corresponding to the most common anxiolytic medicines used in the USA (ie, ‘Alprazolam’, ‘Diazepam’, ‘Lorazepam’, and ‘Clonazepam’) along with their brand names (‘Xanax’, ‘Valium’, ‘Ativan’, and ‘Klonopin’, respectively), and setti…

2019-20 coronavirus outbreakmedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)Population030226 pharmacology & pharmacyDisease Outbreaks03 medical and health sciencessocial medicine0302 clinical medicinePandemicHumansMedicine030212 general & internal medicineGeneral Pharmacology Toxicology and Pharmaceuticseducationeducation.field_of_studyBrand namesSARS-CoV-2business.industryPublic healthpublic healthOutbreakCOVID-19Anxiolytic drugsUnited Statesprimary health careAnti-Anxiety AgentsCOVID-19 mental health primary health care public health social medicinebusinessmental healthDemography
researchProduct

Menstrual problems and lifestyle among Spanish university women

2020

Menstrual problems affect many young women worldwide, conditioning both their academic performance and quality of life. This study sought to analyse the prevalence of menstrual problems and their possible relationship with lifestyle among Spanish university women, as part of a research project (UniHcos Project) involving a cohort of 11 Spanish universities with 7208 university students. A descriptive analysis was performed using the bivariate chi-square test and the Student&rsquo

2402.08 Hábitos AlimentariosHealth Toxicology and Mutagenesislcsh:Medicine:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Menstruation Disturbances [Medical Subject Headings]:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Tobacco Use::Smoking [Medical Subject Headings]Logistic regression:Health Care::Health Care Quality Access and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Regression Analysis::Logistic Models [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]0302 clinical medicineMujeres universitarias - EspañaQuality of lifeTrastornos de la menstruaciónSurveys and QuestionnairesMedicine030212 general & internal medicineWomen college students - Spain:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings]Menstruation Disturbances:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Reproductive Control Agents::Contraceptive Agents [Medical Subject Headings]030219 obstetrics & reproductive medicine:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Questionnaires [Medical Subject Headings]Test (assessment)University students:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings]Dismenorrea:Anthropology Education Sociology and Social Phenomena::Social Sciences::Quality of Life [Medical Subject Headings]Cohort:Anthropology Education Sociology and Social Phenomena::Education::Education Nonprofessional::Students [Medical Subject Headings]Medicina Preventiva y Salud PúblicaFemaleDietamedicine.symptomEstudiantes universitarios - EspañaDietinglifestyleUniversities:Anthropology Education Sociology and Social Phenomena::Education::Schools::Universities [Medical Subject Headings]LifestylesContext (language use):Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings]Affect (psychology)ArticleEstilo de vida6310.09 Calidad de Vida03 medical and health sciencesDysmenorrheaMenstruation disordersHumansWomenuniversity studentsStudentsLife StyleLifestyles - Health aspects:Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]Descriptive statisticsbusiness.industrymenstrual disorderslcsh:RPublic Health Environmental and Occupational Health:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology Social::Life Style [Medical Subject Headings]MujeresLifestyle3212 Salud PublicaMenstruation Disturbances - pathologyDietMenstrual disordersCross-Sectional Studies:Check Tags::Female [Medical Subject Headings]Spain:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior::Alcohol Drinking [Medical Subject Headings]Quality of Life:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Menstruation Disturbances::Dysmenorrhea [Medical Subject Headings]3201.08 GinecologíabusinessDemography
researchProduct

Chiral Serum Pharmacokinetics of 4-Fluoroamphetamine after Controlled Oral Administration

2021

Abstract Over the last two decades, misuse of 4-fluoroamphetamine (4-FA) became an emerging issue in many European countries. Stimulating effects last for 4–6 hours and can impact psychomotor performance. The metabolism of amphetamine-type stimulants is stereoselective and quantification of (R)- and (S)-enantiomers has been suggested for assessing time of use. To date, no data on enantioselective pharmacokinetics is available for 4-FA in serum samples. An enantioselective liquid chromatography−tandem mass spectrometry (LC–MS-MS) method was developed using a chiral Phenomenex® Lux 3 μm AMP column. Validation of the method showed satisfactory selectivity, sensitivity, linearity (0.5–250 ng/mL…

3SAMPLESHealth Toxicology and MutagenesisNETHERLANDSAdministration OralAMPHETAMINEMETABOLISMMETHAMPHETAMINEToxicology01 natural sciencesSTEREOSELECTIVE PHARMACOKINETICSAnalytical Chemistry03 medical and health sciences4-Fluoroamphetamine0302 clinical medicinePharmacokineticsTandem Mass SpectrometryOral administrationmedicineHumansEnvironmental ChemistryIngestion030216 legal & forensic medicineChemical Health and SafetyChromatography34-METHYLENEDIOXYMETHAMPHETAMINEChemistryAmphetamines010401 analytical chemistryTRANSPORTERStereoisomerism4-METHYLENEDIOXYMETHAMPHETAMINESerum samples0104 chemical sciencesStereoselectivityFLUOROAMPHETAMINEEnantiomerPSYCHOACTIVE SUBSTANCES NPSTime of useChromatography Liquidmedicine.drugJournal of Analytical Toxicology
researchProduct

The chemical composition of the aerial parts essential oil of Lonas annua (L.) Vines & Druce (Asteraceae)

2022

Lonas annua (L.) Vines & Druce (Asteraceae), commonly known as African Daisy or Yellow Ageratum is a rare therophyte native to northwestern Africa (Algeria, Morocco, and Tunisia) and Italy (Sicily and Sardinia). In the present study, the chemical composition of the essential oil from aerial parts of Lonas annua was analyzed by GC-MS. No one report has been previously published on the essential oil of this species. The results showed the presence of large quantity of two unusual metabolites 2,3-dihydrofarnesol (41.64%), and acenaphthene (36.18%). Chemotaxonomic considerations were carried out in order to confirm the phylogenetic reconstructions of Anthemideae.

3-dihydrofarnesolchemotaxonomyAfrican Daisycompositaevolatile compositionOrganic Chemistry2Plant ScienceBiochemistrysicilian floraacenaphtheneAnalytical ChemistryNatural Product Research
researchProduct

Synthesis of Rosmarinic Acid Amides as Antioxidative and Hypoglycemic Agents

2019

Type 2 diabetes mellitus (T2DM) is an important metabolic disorder for which there is an urgent need for new antidiabetic drugs. α-Glucosidase inhibition is an established protocol for T2DM therapy. Because hyperglycemia causes oxidative tissue damage, the development of agents with both α-glucosidase inhibition and antioxidant activity from natural or natural-derived polyphenols such derivatives of rosmarinic acid (RA) represents an attractive therapeutic option. We report a study on amides 1-10 derived from RA and their evaluation for yeast α-glucosidase inhibition and antioxidant activity (DPPH and ORAC tests). All amides showed higher inhibitory activity than that of RA, were by far mor…

3003DrugAntioxidantDPPHProton Magnetic Resonance Spectroscopymedia_common.quotation_subjectmedicine.medical_treatmentPharmaceutical ScienceOxidative phosphorylationPharmacologyDepsides01 natural sciencesAntioxidantsAnalytical Chemistrychemistry.chemical_compoundDrug DiscoverymedicineHypoglycemic AgentsSettore BIO/15 - Biologia FarmaceuticaCarbon-13 Magnetic Resonance SpectroscopyIC50media_commonAcarbosePharmacology010405 organic chemistrydiabetes mellituDrug Discovery3003 Pharmaceutical ScienceRosmarinic acidOrganic ChemistrySettore CHIM/06 - Chimica OrganicaComplementary and Alternative Medicine2708 DermatologyAmidesamide0104 chemical sciences010404 medicinal & biomolecular chemistryRosmarinic acidComplementary and alternative medicinechemistryCinnamatesPolyphenolAnalytical Chemistry; Molecular Medicine; Pharmacology; 3003; Drug Discovery3003 Pharmaceutical Science; Complementary and Alternative Medicine2708 Dermatology; Organic ChemistryMolecular Medicineα-glucosidasemedicine.drug
researchProduct

PEG 400/Cerium Ammonium Nitrate Combined with Microwave-Assisted Synthesis for Rapid Access to Beta-Amino Ketones. An Easy-to-Use Protocol for Discov…

2018

Compound libraries are important requirement in target-based drug discovery. In the present work, a small focused compound library based on β-aminoketone scaffold has been prepared combining microwave-assisted organic synthesis (MAOS) with polymer-assisted solution phase synthesis (PASPS) and replacing reaction workup standard purification procedures with solid phase extraction (SPE). Specifically, the effects of solvent, such as dioxane, dimethylformamide (DMF), polyethylene glycol 400 (PEG 400), temperature, irradiation time, stoichiometric ratio of reagents, and catalysts (HCl, acetic acid, cerium ammonium nitrate (CAN)) were investigated to maximize both conversion and yield. The optimi…

3003Transcription FactorPharmaceutical ScienceNitratePolyethylene Glycol01 natural sciencesPolyethylene GlycolsPolymer-assisted solution phase synthesiAnalytical Chemistrychemistry.chemical_compoundDrug DiscoveryMannich reactionSolid phase extractionMicrowavesβ-aminoketonesCeriumKetonesKetoneDNA-Binding ProteinsSolventCeriumChemistry (miscellaneous)Molecular MedicineDimethylformamideMicrowave-assisted organic synthesiMannich reaction; β-aminoketones; microwave-assisted organic synthesis; polymer-assisted solution phase synthesis; solid phase extraction; drug discoveryDNA-Binding ProteinBacterial Proteinchemistry.chemical_elementPolyethylene glycol010402 general chemistryArticlelcsh:QD241-441Bacterial Proteinslcsh:Organic chemistryΒ-aminoketonePhysical and Theoretical ChemistrySolid phase extractionpolymer-assisted solution phase synthesisPEG 400Nitrates010405 organic chemistryDrug Discovery3003 Pharmaceutical ScienceOrganic ChemistrySettore CHIM/08 - Chimica FarmaceuticaCombinatorial chemistry0104 chemical scienceschemistryYield (chemistry)microwave-assisted organic synthesisOrganic synthesisMicrowaveTranscription FactorsMolecules
researchProduct

The emerging role of 3D printing in the fabrication of detection systems

2021

Abstract 3D printing is fast evolving as an additive manufacturing technique that has been adopted in (bio)analytical science because of the ample variety of materials and technologies currently available for highly affordable prototyping. This review focuses on the unique characteristics of 3D printing for manufacturing of optical and electrochemical detection systems, and sampling interfaces for analytical purposes using fused deposition modelling, vat polymerization (stereolithography and digital light processing) and photopolymer inkjet printing. The majority of works surveyed within the time span of mid-2018 to mid-2020 encompassed the fabrication of several components of the detection…

3d printedFabricationEmerging technologiesComputer sciencebusiness.industry010401 analytical chemistry3D printingElectrochemical detection01 natural sciences0104 chemical sciencesAnalytical Chemistrylaw.inventionlawSystems engineeringDigital Light ProcessingbusinessSpectroscopyStereolithographyInkjet printingTrAC Trends in Analytical Chemistry
researchProduct

ATR-Spin: an open-source 3D printed device for direct cytocentrifugation onto attenuated total reflectance crystals.

2021

Infrared Spectroscopy (IR) enables the direct and rapid characterization of cells at the molecular level. Achieving a rapid and consistent cell preparation is critical for the development of Point-of-Care diagnostics for cell analysis. Here we introduce an open-source, 3D printed device for integrating the isolation, preconcentration, and measurement of attenuated total reflectance IR spectra of cells from biofluids. The tool comprises a disposable card for cytocentrifugation, equipped with magnets, which allows reproducible integration into the pathlength of the IR spectrophotometer. Preliminary results using cell media containing A459 cells indicate that this system enables a qualitative …

3d printedMaterials scienceSpectrophotometry Infraredbusiness.industryCell preparation010401 analytical chemistryBiomedical EngineeringInfrared spectroscopyBioengineeringCell analysis02 engineering and technologyGeneral Chemistry021001 nanoscience & nanotechnology01 natural sciencesBiochemistry0104 chemical sciencesOpen sourceMolecular levelAttenuated total reflectionPrinting Three-DimensionalSpectroscopy Fourier Transform InfraredOptoelectronics0210 nano-technologybusinessLab on a chip
researchProduct