Search results for "Médical"
showing 10 items of 109 documents
Expertise préalable à la création d’un tableau de maladie professionnelle ou à l’élaboration de recommandations aux comités régionaux de reconnaissan…
2022
L’amiante est classé en tant que substance cancérogène avérée pour l’humain (groupe 1 du Centre International de Recherche sur la Cancer (CIRC)) depuis les années 70 pour le poumon et la plèvre. La monographie sur l’amiante actualisée en 2012 indique que des preuves suffisantes sont maintenant disponibles pour démontrer le lien entre l’exposition à l’amiante et les cancers du larynx et de l'ovaire. Dans cette monographie, les cancers du pharynx, de l’estomac et les cancers colorectaux sont considérés comme possiblement liés à une exposition à l’amiante, mais avec un niveau de preuve limité.A ce jour, seuls les cancers broncho-pulmonaires provoqués par l'inhalation de poussières d'amiante [t…
Optimisation non-lisse pour l'estimation de composants immunitaires cellulaires dans un environnement tumoral
2021
In this PhD proposal we will investigate new regularization methods of inverse problems that provide an absolute quantification of immune cell subpopulations. The mathematical aspect of this PhD proposal is two-fold. The first goal is to enhance the underlying linear model through a more refined construction of the expression matrix. The second goal is, given this linear model, to derive the best possible estimator. These two issues can be treated in a decoupled way, which is the standard for existing methods such as Cibersort, or as a coupled optimization problem (which is known as blind deconvolution in signal processing).
Emergence of Aspergillus fumigatus azole resistance in azole-naïve patients with chronic obstructive pulmonary disease and their homes.
2017
Azole-resistant Aspergillus fumigatus (ARAF) has been reported in patients with chronic obstructive pulmonary disease (COPD) but has not been specifically assessed so far. Here, we evaluated ARAF prevalence in azole-naïve COPD patients and their homes, and assessed whether CYP51A mutations were similar in clinical and environmental reservoirs. Sixty respiratory samples from 41 COPD patients with acute exacerbation and environmental samples from 36 of these patient's homes were prospectively collected. A. fumigatus was detected in respiratory samples from 11 of 41 patients (27%) and in 15 of 36 domiciles (42%). Cyp51A sequencing and selection on itraconazole medium of clinical (n = 68) and e…
Les recherches sur le goût aux frontières de la recherche biomédicale
2013
Présentation orale (29 p.) à l'attention des pouvoirs publics; Les recherches sur le "goût" telle que menées au Centre des Sciences du Goût et de l'Alimentation font appel à des sujets humains pour mener les expérimentations. Pour autant, peut-on dire que ce sont des recherches "pratiquées sur l'être humain en vue du développement des connaissances biologiques ou médicales" (Article L1121-1 du Code de Santé Publique) ? Et doit- on dans ce cas déposer les protocoles auprès des comités de protection de personnes et de l'autorité compétente ? La réponse à cette question dépend à la fois de l'objectif de la recherche, de la place du sujet, des notions de de "procédure supplémentaire" et de risq…
Former ou accompagner : une tension difficile à vivre pour les formateurs en IFSI
2019
International audience
Chaînage de bases de données anonymisées pour les études épidémiologiques multicentriques nationales et internationales : proposition d'un algorithme…
2009
Background: Compiling individual records coming from different sources is very important for multicenter epidemiological studies; however, European directives and other national legislation concerning nominal data processing must be respected. These legal aspects can be satisfied by implementing mechanisms that allow anonymization of patient data (such as hashing techniques). Moreover, for security reasons, official recommendations suggest using different cryptographic keys in combination with a cryptographic hash function for each study. Unfortunately, this type of anonymization procedure is in contradiction with common requirements in public health and biomedical research because it becom…
Outcomes with intracytoplasmic sperm injection of cryopreserved sperm from men with spinal cord injury
2013
Erectile dysfunction, ejaculatory dysfunction and poor semen quality are the main causes of infertility in men with spinal cord injury (SCI). Different sperm retrieval techniques such as penile vibratory stimulation (PVS), electro-ejaculation (EEJ) or surgical sperm retrieval (SSR) associated or not with sperm cryopreservation can be offered to these patients to preserve their fertility. If fatherhood cannot be achieved naturally, assisted reproductive techniques can be offered to these patients using either fresh or frozen/thawed sperm. The aim of the study was to report in SCI patients from Dijon (Burgundy) and in the literature, intracytoplasmic sperm injection (ICSI) outcomes using froz…
LEXOP: a lexical database providing orthography-phonology statistics for French monosyllabic words.
1999
During the last 20 years, psycholinguistic research has identified many variables that influence reading and spelling processes. We describe a new computerized lexical database, LEXOP, which provides quantitative descriptors about the relations between orthography and phonology for French monosyllabic words. Three main classes of variables are considered: consistency of print-to-sound and sound-to-print associations, frequency of orthography-phonology correspondences, and word neighborhood characteristics.
Principe de précaution et assistance médicale à la procréation : l'ICSI
2004
International audience
Les premiers dictionnaires médicaux en langue anglaise : glissements diachroniques du spécialisé au non spécialisé
2011
Abstract In the field of languages for specific purposes, the diachronic study of medical dictionaries published in English is a territory that remains largely unchartered. The aim of this study is to pinpoint and analyse the emergence of the first medical glossaries and dictionaries in Great Britain so as to mark out the specialised territory of medical English. The specialised domain, as defined by Michel Petit, and the analysis of the passage from the specialised to the non-specialised domain put forward by Michel Van der Yeught provide the theoretical background to the study, which spans the 17th and 18th century. The corpus comprises both general English dictionaries and the first spec…