Search results for "Médical"
showing 10 items of 109 documents
Nouvelle approche pour l'estimation du rythme respiratoire basée sur la photopléthysmographie sans contact
2021
Respiratory rhythm is important information in medical context.Its assessment allows to predict some medical complications that could lead to death.However, it is often neglected by the medical staff due to a bad comprehension of its importance, or a lack of time.Automated measurement methods allow to improve this by continuously giving respiratory rate.Most of these methods needs a contact with the patient to efficiently measure the breathing rate.Unfortunately it leads to some issues which could forbid measurement or make it unconfortable for continuous monitoring.The continuous, every-day monitoring especially needs to be as discrete as possible to be forgotten by the patient.To deal wit…
Efficacy of a 12-Week Simeprevir Plus Peginterferon/Ribavirin (PR) Regimen in Treatment-Naïve Patients with Hepatitis C Virus (HCV) Genotype 4 (GT4) …
2017
Background HCV GT4 accounts for up to 20% of HCV infections worldwide. Simeprevir, given for 12 weeks as part of a 24- or 48-week combination regimen with PR is approved for the treatment of chronic HCV GT4 infection. Primary study objectives were assessment of efficacy and safety of simeprevir plus PR in treatment-naïve patients with HCV GT4 treated for 12 weeks. Primary efficacy outcome was sustained virologic response 12 weeks post-treatment (SVR12). Additional objectives included investigation of potential associations of rapid virologic response and baseline factors with SVR12. Methods This multicentre, open-label, single-arm study (NCT01846832) evaluated efficacy and safety of simepre…
Rapport annuel 2006-2007 de l'Observatoire national de la démographie des professions de santé.
2008
Ce troisième rapport de l'Observatoire national de la démographie des professions de santé comporte une synthèse générale assortie de préconisations et de quatre tomes thématiques : la médecine générale (tome 1), les internes en médecine (tome 2), la profession de chirurgien dentiste et les métiers de la périnatalité (tome 3), les métiers de la cancérologie (tome 4).
Rapid differentiation between livestock-associated and livestock-independent Staphylococcus aureus CC398 clades.
2013
Staphylococcus aureus clonal complex 398 (CC398) isolates cluster into two distinct phylogenetic clades based on single-nucleotide polymorphisms (SNPs) revealing a basal human clade and a more derived livestock clade. The scn and tet(M) genes are strongly associated with the human and the livestock clade, respectively, due to loss and acquisition of mobile genetic elements. We present canonical single-nucleotide polymorphism (canSNP) assays that differentiate the two major host-associated S. aureus CC398 clades and a duplex PCR assay for detection of scn and tet (M). The canSNP assays correctly placed 88 S. aureus CC398 isolates from a reference collection into the human and livestock clade…
Focal DNA Copy Number Changes in Neuroblastoma Target MYCN Regulated Genes
2013
Neuroblastoma is an embryonic tumor arising from immature sympathetic nervous system cells. Recurrent genomic alterations include MYCN and ALK amplification as well as recurrent patterns of gains and losses of whole or large partial chromosome segments. A recent whole genome sequencing effort yielded no frequently recurring mutations in genes other than those affecting ALK. However, the study further stresses the importance of DNA copy number alterations in this disease, in particular for genes implicated in neuritogenesis. Here we provide additional evidence for the importance of focal DNA copy number gains and losses, which are predominantly observed in MYCN amplified tumors. A focal 5 kb…
D2R striatopallidal neurons inhibit both locomotor and drug reward processes.
2009
The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D(2)R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.
Conceptual graph operations for formal visual reasoning in the medical domain
2014
International audience; Objective - Conceptual graphs (CGs) are used to represent clinical guidelines because they support visual reasoning with a logical background, making them a potentially valuable representation for guidelines.Materials and methods - Conceptual graph formalism has an essential and basic component: a formal vocabulary that drives all of the other mechanisms, notably specialization and projection. The graph's theoretical operations, such as projection, rules, derivation, constraints, probabilities and uncertainty, support diagrammatic reasoning.Results - A conceptual graph's graphical user interface includes a multilingual vocabulary management, some query and decision-m…
Dispositif virtuel d'aide à la chirurgie de l'épaule
2008
The goal of this research is to design a virtual reality prototype to assit an orthopedic surgeon during the replacement of the glenohumeral joint by prosthesis. This system aims to optimize the movements of prosthesized shoulder joint from a choice of various scenarios of pose. These works encompasses several topics such as : orthopedic surgery, image analysis, computer graphics and virtual reality. The chosen process includes a phase of modelling of the bony part of the articulation by simple geometric forms, this model is parameterized from radios or CT scans ; a phase of simulation of the movements of healthy glenohumeral joint ; nally the phase of simulation of cutting and drilling wit…
Modélisation, Analyse et Traitement de l'Information
2016
Mes activités de recherche s’articulent, d’une part, autour de l’instrumentation et du génie biomédical,et, d’autre part, autour du traitement et de la transmission non linéaire de l’information. Elles sebasent sur la modélisation des signaux à partir de modèles non linéaires (principalement modèles deréaction-diffusion. . . ) continus (EDP) et discrets (numériques). Dans cette partie, d’un point de vuefondamental, des phénomènes dynamiques complexes ou chaotiques sont caractérisés à travers l’analyse,la classification, la reconnaissance des motifs dans des signaux physiologiques ou issus des circuitsélectroniques. Un autre axe sur lequel je travaille concerne l’analyse et le traitement des…
Comportement du médecin et politique économique de santé. Quelle rationalité pour quelle éthique ?
2006
International audience