Search results for "M1"
showing 10 items of 837 documents
Salomó Saporta: un mercader judío ante la Inquisición valenciana
2017
La persecución inquisitorial contra los judíos no ha sido un tema abordado sistemáticamente por la historiografía, porque las investigaciones sobre la represión de los tribunales inquisitoriales en el tránsito entre los siglos XV y XVI se han centrado en el grupo judeoconverso. Y si bien es cierto que la Inquisición moderna utilizó algunos procesamientos a hebreos de manera ejemplarizante para resaltar el peligro que representaban para la comunidad cristiana, y que han sido recogidos posteriormente por los investigadores, el caso de Salomó Saporta ha sido estudiado y comentado como un caso aislado. Por esa razón quizás sea el momento de plantear la necesidad de estudiar los mecanismos coerc…
La llamada inscripción de Adoniram y el cementerio judío de Sagunto
1995
At the end of the 15th century a Hebrew inscription on a gravestone found in Sagunto, having been wrongly read, was attributed to Adoniram, a tax collector of Solomon. The discovery aroused a long and excited discussion; many scholars denied its authenticity affirming that it was a literary fiction. But a wrong reading does not imply an epigraphic forgery. In this article the author brings new manuscript sources which confirm the authenticity of the find and show which was the place of the Jewish cemetery in Sagunto. He also tries to reconstruct the original text of the inscription. A finales del siglo XV se encontró en Sagunto una inscripción hebrea sobre una lápida que, por una lectura er…
Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins.
2001
The L1 adhesion molecule plays an important role in axon guidance and cell migration in the nervous system. L1 is also expressed by many human carcinomas. In addition to cell surface expression, the L1 ectodomain can be released by a metalloproteinase, but the biological function of this process is unknown. Here we demonstrate that membrane-proximal cleavage of L1 can be detected in tumors and in the developing mouse brain. The shedding of L1 involved a disintegrin and metalloproteinase (ADAM)10, as transfection with dominant-negative ADAM10 completely abolishes L1 release. L1-transfected CHO cells (L1-CHO) showed enhanced haptotactic migration on fibronectin and laminin, which was blocked …
Transcription of genes in the biosynthetic pathway for fumonisin mycotoxins is epigenetically and differentially regulated in the fungal maize pathog…
2012
ABSTRACT When the fungal pathogen Gibberella moniliformis (anamorph, Fusarium verticillioides ) colonizes maize and maize-based products, it produces class B fumonisin (FB) mycotoxins, which are a significant threat to human and animal health. FB biosynthetic enzymes and accessory proteins are encoded by a set of clustered and cotranscribed genes collectively named FUM, whose molecular regulation is beginning to be unraveled by researchers. FB accumulation correlates with the amount of transcripts from the key FUM genes, FUM1 , FUM21 , and FUM8 . In fungi in general, gene expression is often partially controlled at the chromatin level in secondary metabolism; when this is the case, the deac…
Participating Laboratories. Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and isl…
2008
The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity
2005
The cellular prion protein (PrP(c)) is physiologically cleaved in the middle of its 106-126 amino acid neurotoxic region at the 110/111 downward arrow112 peptidyl bond, yielding an N-terminal fragment referred to as N1. We recently demonstrated that two disintegrins, namely ADAM10 and ADAM17 (TACE, tumor necrosis factor alpha converting enzyme) participated in both constitutive and protein kinase C-regulated generation of N1, respectively. These proteolytic events were strikingly reminiscent of those involved in the so-called "alpha-secretase pathway" that leads to the production of secreted sAPPalpha from betaAPP. We show here, by transient and stable transfection analyses, that ADAM9 also…
Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulat…
2003
Tumor necrosis factor-alpha converting enzyme (TACE or ADAM17) is a member of the ADAM (a disintegrin and metalloproteinase) family of type I membrane proteins and mediates the ectodomain shedding of various membrane-anchored signaling and adhesion proteins. TACE is synthesized as an inactive zymogen, which is subsequently proteolytically processed to the catalytically active form. We have identified the proprotein-convertases PC7 and furin to be involved in maturation of TACE. This maturation is negatively influenced by the phorbol ester phorbol-12-myristate-13-acetate (PMA), which decreases the cellular amount of the mature form of TACE in PMA-treated HEK293 and SH-SY5Y cells. Furthermore…
TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex
2021
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively kills various cancer cell types, but also leads to the activation of signaling pathways that favor resistance to cell death. Here, we investigated the as yet unknown roles of calcium signaling and autophagy regulatory proteins during TRAIL-induced cell death in leukemia cells. Taking advantage of the Gene Expression Profiling Interactive Analysis (GEPIA) project, we first found that leukemia patients present a unique TRAIL receptor gene expression pattern that may reflect their resistance to TRAIL. The exposure of NB4 acute promyelocytic leukemia cells to TRAIL induces intracellular Ca2+ influx through a calcium rel…
A Newman property for BLD-mappings
2019
We define a Newman property for BLD-mappings and prove that for a BLD-mapping between generalized manifolds equipped with complete path-metrics, this property is equivalent to the branch set being porous when the codomain is LLC. peerReviewed
Three-page encoding and complexity theory for spatial graphs
2004
We construct a series of finitely presented semigroups. The centers of these semigroups encode uniquely up to rigid ambient isotopy in 3-space all non-oriented spatial graphs. This encoding is obtained by using three-page embeddings of graphs into the product of the line with the cone on three points. By exploiting three-page embeddings we introduce the notion of the three-page complexity for spatial graphs. This complexity satisfies the properties of finiteness and additivity under natural operations.