Search results for "M1"
showing 10 items of 837 documents
Música y ceremonial, una perspectiva caleidoscópica e interdisciplinar
2020
Las relaciones establecidas en el marco de los modelos celebrativos (religiosos, urbanos y cortesanos) que se conformaron en la Edad Media, y que se reinterpretaron a lo largo de la Edad Moderna y principios de la Contemporánea, han sido objeto de reinvenciones y reformulaciones en el siglo XX y continúan siéndolo hoy en día. En las últimas décadas, la musicología europea y latinoamericana ha prestado una creciente atención a las relaciones indisolubles entre la música y su contexto ceremonial o al ceremonial y sus sonidos, a modo de dos caras de una misma moneda.
Human DNA Telomeres in Presence of Oxidative Lesions: The Crucial Role of Electrostatic Interactions on the Stability of Guanine Quadruplexes
2019
By using all atom molecular dynamics simulations, we studied the behavior of human DNA telomere sequences in guanine quadruplex (G4) conformation and in the presence of oxidative lesions, namely abasic sites. In particular, we evidenced that while removing one guanine base induces a significant alteration and destabilization of the involved leaflet, human telomere oligomers tend, in most cases, to maintain at least a partial quadruplex structure, eventually by replacing the empty site with undamaged guanines of different leaflets. This study shows that (i) the disruption of the quadruplex leaflets induces the release of at least one of the potassium cations embedded in the quadruplex channe…
Coffee Restores Expression of lncRNAs Involved in Steatosis and Fibrosis in a Mouse Model of NAFLD
2021
Background and aim: Coffee intake exerts protective effects against non-alcoholic fatty liver disease (NAFLD), although without fully cleared mechanisms. In this study we aimed to assess whether coffee consumption may influence the expression of long non-coding RNAs (lncRNAs) in the liver. Methods: C57BL/6J mice were fed a 12-week standard diet (SD), high-fat diet (HFD) or HFD plus decaffeinated coffee solution (HFD + coffee). Expression of specific lncRNAs involved in NAFLD was analyzed by real-time PCR. For the most differentially expressed lncRNAs, the analysis was also extended to their mRNA targets. Results: Decaffeinated coffee intake reduced body weight gain, prevented NAFLD, lowered…
The Correlation Between Human Capital and Gross Added Value in the Bioeconomy Sectors at the European Union (EU) Country Level
2019
Abstract The paper aims to prove the link between human capital and gross added value in bioeconomy sectors in the EU countries. Data from EUROSTAT data base regarding employment and gross added value in 6 bioeconomy sectors were used in a cross-country regression analysis. The econometric analysis of cross-country data shows a positive correlation between human capital in bioeconomy sectors and their gross output in 2015 in 26 European countries. It is found also that the correlation is stronger in the highly developed economies as in the central-eastern countries, as well as in the European economy.
Monocītu - makrofāgu diferenciācijas noteikšana, izmantojot plūsmas citometrijas un mikroskopijas metodes
2017
Monocīti ir cilvēka organisma šūnas, kuras aktīvi reaģē uz vides izmaiņām. Noteiktos apstākļos, reaģējot uz vides stimulāciju, tie migrē uz iekaisuma vai bojājuma vietu organismā un atbilstoši maina funkcionālo fenotipu, diferencējoties par makrofāgiem. Zināms, ka monocīti var diferencēties par atšķirīgu tipu makrofāgiem. Klasiski tiek izdalīti divi polarizētu makrofāgu tipi: M1 makrofāgiem ir svarīga loma gan pie iedzimtās, gan pie adaptīvās imunitātes, bet M2 makrofāgi atbild par audu atjaunošanu un ir saistīti ar hroniskām infekcijas slimībām. Šī darba mērķis bija izstrādāt monocītu – makrofāgu diferenciācijas modeli, ko varētu izmantot bioloģiski aktīvu faktoru pētījumos. Šūnu morfoloģi…
A Single-Case, Mixed Methods Study Exploring the Role of Music Listening in Vibroacoustic Treatment
2019
Chronic pain is a widespread issue accompanied commonly by depression and anxiety. Chronic pain has been shown to alter brain processing within the emotional and reward circuits, pointing towards a possible link between pain and comorbid mood disorders. Pain relief may be achieved by alleviating depressive and anxious symptoms. Relaxation is important for pain relief and eliciting relaxation through music listening is shown to relieve pain, depression, anxiety, and discomfort among others. In addition to auditory stimuli, Vibroacoustic treatment – the tactile application of low frequency sinusoidal sound vibration, plus music listening and therapeutic interaction – has been shown to be bene…
Spontaneous Music-Evoked Autobiographical Memories in Individuals Experiencing Depression
2020
Listening to music often triggers strong memories of events from our past, which influence how we affectively experience music listening and can therefore contribute to music’s therapeutic capacity. The aim of this study was to examine the valence and content of spontaneous music-evoked autobiographical memories (MEAMs) in listeners with self-reported depression, who typically demonstrate negatively biased autobiographical memory. Eighteen depressed and 21 controls participated in a music-listening experiment where they listened to a personalized music stimulus, described their memories, and thereafter rated the valence of these memories and of their induced affect. Participants’ ratings w…
The Efficient Management of the Material Resources - One ot the most Important Premises in Promoting and Increasing of Business
2011
Even if we are talking about different periods of time, periods in which the economy of the states have met different levels of development, the material resources have maintained their importance and distinctness, no matter what the evolution, activity, or size of the company was. The resort of the materials with everything it includes, supply, management and consumption have been considered a main priority for every kind of management. Not only because the field of the materials is a cvasi permanent one, for all the types of companies, but also because this field could easily represent the basics of what is called profit achievement, competitiveness, efficiency, promotion and development …
Adaptación al castellano y estructura factorial del Denison Organizational Culture Survey
2009
[EN]: This article presents a Spanish adaptation of the Denison Organizational Culture Survey, a questionnaire designed to evaluate organizational culture. This survey consists of 60 items, grouped in 12 subscales, which identify 4 cultural dimensions. These dimensions have been widely studied and their influence in organizational effectiveness has been accepted. This adaptation was applied to 488 participants, and analysed with confirmatory factor analysis. Results show adequate psychometric properties, so it can be concluded that the Spanish adaptation almost completely replicates the structure of the original version in English. © 2009 Psicothema.
Effects of conversation content on viewing dyadic conversations
2016
People typically follow conversations closely with their gaze. We asked whether this viewing is influenced by what is actually said in the conversation and by the viewer’s psychological condition. We recorded the eye movements of healthy (N = 16) and depressed (N = 25) participants while they were viewing video clips. Each video showed two people, each speaking one line of dialogue about socio-emotionally important (i.e., personal) or unimportant topics (matter-of-fact). Between the spoken lines, the viewers made more saccadic shifts between the discussants, and looked more at the second speaker, in personal vs. matter-of-fact conversations. Higher depression scores were correlated with les…