Search results for "M2"

Gel dosimeters for radiotherapy applications

2014

Report on cpm 2011 and stringmasters 2011

2011

L'enseignement des langues vivantes à l'école élémentaire : essai d'évaluation des effets au collège

1997

A survey was carried out during two years with 1500 pupils at the beginning of the secondary school. It consists to assess the results of the pupils in English language : some of them were initiated to English in the Primary school. The results of the research allow to describe some factors which influence pupil's acquisitions in English language and to assess the effects of the "early" initiation : in fact, these seem to be very slight.

Varying-coefficient functional linear regression models

2008

This article considers a generalization of the functional linear regression in which an additional real variable influences smoothly the functional coefficient. We thus define a varying-coefficient regression model for functional data. We propose two estimators based, respectively, on conditional functional principal regression and on local penalized regression splines and prove their pointwise consistency. We check, with the prediction one day ahead of ozone concentration in the city of Toulouse, the ability of such nonlinear functional approaches to produce competitive estimations.

Vassiliev invariants for braids on surfaces

2000

We show that Vassiliev invariants separate braids on a closed oriented surface, and we exhibit an universal Vassiliev invariant for these braids in terms of chord diagrams labeled by elements of the fundamental group of the considered surface.

Drone-teknologia ja sen hyväksymisen haasteet siviiliympäristössä

2017

Tämä tutkielma tarkastelee drone-teknologiaa ja sen hyväksymistä UTAUT-mallin näkökulmasta. Tutkielma ottaa selvää siitä miten drone-teknologiaa on tarkasteltu sen eri käyttöympäristöissä ja vastaa kysymyksiin: miten droneja on pyritty hyödyntämään siviiliympäristössä ja minkälaisia ongelmia kyseisen teknologian hyväksyntä kohtaa. Tutkielma on toteutettu kirjallisuuskatsauksena hyödyntäen uutisia ja tieteellisiä julkaisuita. Materiaalin perusteella useimmat kansalaiset ja organisaatiot ovat vielä halut-tomia käyttämään drone-teknologiaa itse. Useimmat kansalaiset eivät näe tarvetta omistaa omaa dronea tai kykene kuvittelemaan moraalisesti hyväksyttävää käyttötapaa yksityiselle dronelle. Ala…

A Regulatory Mechanism Involving TBP-1/Tat-Binding Protein 1 and Akt/PKB in the Control of Cell Proliferation

2011

Abstract TBP-1 /Tat-Binding Protein 1 (also named Rpt-5, S6a or PSMC3) is a multifunctional protein, originally identified as a regulator of HIV-1-Tat mediated transcription. It is an AAA-ATPase component of the 19S regulative subunit of the proteasome and, as other members of this protein family, fulfils different cellular functions including proteolysis and transcriptional regulation. We and others reported that over expression of TBP-1 diminishes cell proliferation in different cellular contexts with mechanisms yet to be defined. Accordingly, we demonstrated that TBP-1 binds to and stabilizes the p14ARF oncosuppressor increasing its anti-oncogenic functions. However, TBP-1 restrains cell…

Source and Nature of Inhaled Atmospheric Dust from Trace Element Analyses of Human Bronchial Fluids

2011

International audience; Rapid volcanic eruptions quickly ejecting large amounts of dust provoke the accumulation of heavy metals in people living in surrounding areas. Analyses of bronchoalveolar lavage samples (BAL) collected from people exposed to the paroxysmal 2001 Etna eruption revealed a strong enrichment of many toxic heavy metals. Comparing the BAL to the dust composition of southeastern Sicily, we found that only V, Cr, Mn, Fe, Co, and U enrichment could be related to the volcanic event, whereas Ni, Cu, Cd, and Pb contents come from the dissolution of particles of anthropogenic origin. Furthermore, the nature of these inhaled anthropogenic particles was revealed by anomalous La and…

The Mitochondrial Targeting Chaperone 14-3-3ε Regulates a RIG-I Translocon that Mediates Membrane Association and Innate Antiviral Immunity

2012

SummaryRIG-I is a cytosolic pathogen recognition receptor that initiates immune responses against RNA viruses. Upon viral RNA recognition, antiviral signaling requires RIG-I redistribution from the cytosol to membranes where it binds the adaptor protein, MAVS. Here we identify the mitochondrial targeting chaperone protein, 14-3-3ε, as a RIG-I-binding partner and essential component of a translocation complex or “translocon” containing RIG-I, 14-3-3ε, and the TRIM25 ubiquitin ligase. The RIG-I translocon directs RIG-I redistribution from the cytosol to membranes where it mediates MAVS-dependent innate immune signaling during acute RNA virus infection. 14-3-3ε is essential for the stable inte…

Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists.

2003

A series of 2,3-disubstituted indenes, which are analogues of the widely used histamine H(1) receptor antagonist dimethindene, have been synthesized and studied as muscarinic and histamine receptor antagonists. The affinities of these compounds for the five human muscarinic receptor subtypes (M(1)-M(5)) and for human histamine H(1) receptors were determined in radioligand binding studies using membranes from transfected Chinese hamster ovary (CHO) cells and [(3)H]N-methylscopolamine ([(3)H]NMS). The results demonstrate that the diisopropyl analogue 19 has a similar high affinity as (S)-dimethindene at M(2) receptors ((S)-dimethindene: pK(i) = 7.52; (-)-19: pK(i) = 7.37) with an improved sel…