Search results for "M2"
showing 6 items of 256 documents
Modelling biological nitrogen and phosphorus removal with soluble microbial products (SMP) production-degradation processes
2011
Over the last two decades, Membrane Bioreactors (MBR) are increasingly used for wastewater treatment. Mathematical modelling of MBR systems has played a key role in order to better explain the effect of their peculiarities. Indeed, several MBR models have been presented in literature in order to improve the knowledge on MBR systems: biological models, hybrid models which include soluble microbial product (SMP) modelling, physical models able to describe the membrane fouling and integrated models which couple the hybrid models with the physical ones. However, among the existing MBR models only few integrated models have been developed which take into account the existing relationship between…
Enhancing the performance of HSDPA communication with multipoint transmission techniques
2015
The evolution of mobile phones, tablets and other mobile communication devices has led to a significant increase in the amount of data delivered over mobile networks. In order to satisfy the climbing data rate demands of customers, existing mobile broadband networks are being expanded with new features that allow ubiquitous and consistent networking experience. This research presents three multipoint transmission techniques for Wideband Code Division Multiple Access (WCDMA) based High-Speed Downlink Packet Access (HSDPA) communication protocol. Multiflow, High-Speed Single-Frequency Network (HS-SFN) and Multipoint-to-Point Single-Frequency Network (M2P-SFN) enable transmission of user-dedicat…
On the CAT(0) dimension of 2-dimensional Bestvina-Brady groups
2002
Let K be a 2-dimensional finite flag complex. We study the CAT(0) dimension of the `Bestvina-Brady group', or `Artin kernel', Gamma_K. We show that Gamma_K has CAT(0) dimension 3 unless K admits a piecewise Euclidean metric of non-positive curvature. We give an example to show that this implication cannot be reversed. Different choices of K lead to examples where the CAT(0) dimension is 3, and either (i) the geometric dimension is 2, or (ii) the cohomological dimension is 2 and the geometric dimension is not known.
Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille’s heel to be exploited for the therapy of MYCN amplified neurob…
2012
The p53 oncosuppressor is very seldom mutated in neuroblastoma, but several mecha- nisms cooperate to its functional inactivation in this tumor. Increased MDM2 levels, due to genetic amplification or constitutive inhibition of p14ARF, significantly contribute to this event highlighting p53 reactivation as an attractive perspective for neuroblastoma treat- ment. In addition to its role in tumorigenesis, MYCN sensitizes untransformed and cancer cells to apoptosis. This is associated to a fine modulation of the MDM2-p53 pathway Indeed MYCN induces p53 and MDM2 transcription, and, by evoking a DNA damage response (DDR), it stabilizes p53 and its proapoptotic kinase Homeodomain Interacting Prote…
Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuat…
2021
The tumor resistance to p53 activators posed a clinical challenge. Combination studies disclosed that concomitant administration of Bcl2 inhibitors can sensitize the tumor cells and induce apoptosis. In this study, we utilized a rapid synthetic route to synthesize two novel hybrid spirooxindole-based p53-MDM2 inhibitors endowed with Bcl2 signaling attenuation. The adducts mimic the thematic features of the chemically stable potent spiro [3H-indole-3,2′-pyrrolidin]-2(1H)-ones p53-MDM2 inhibitors, while installing a pyrrole ring via a carbonyl spacer inspired by the natural marine or synthetic products that efficiently inhibit Bcl2 family functions. A chemical insight into the two synthesized…
Pour une politique de la qualité de l'école primaire en Afrique : évaluation des acquis des élèves en CP et en CM au Togo
1993
Policy decisions in education cannot be made upon opinions and subjectives factors ; this is especially true in African countries where demographic and economic constraints are particularly binding. A key element is to measure the impact of the various factors affecting student learning, even though this step has to be complemented by cost estimates so as to produce cost-efficiency indicators. This papers concerns primary schooling in Togo and aims at documenting the link between school factors on the one hand, pupil achievement on the other. The results have very clear consequences in terms of educational policy since they show that inputs such as school building in concrete or recruitemen…