Search results for "M2"
showing 10 items of 256 documents
The polyhedral Hodge number $h^{2,1}$ and vanishing of obstructions
2000
We prove a vanishing theorem for the Hodge number $h^{2,1}$ of projective toric varieties provided by a certain class of polytopes. We explain how this Hodge number also gives information about the deformation theory of the toric Gorenstein singularity derived from the same polytope. In particular, the vanishing theorem for $h^{2,1}$ implies that these deformations are unobstructed.
A presentation and a representation of the Held group
1996
In this note we give a brief description of a new presentation of the Held group, which is deduced only from the original work of D. Held in 1969, who shows that a finite simple group, having the same centralizer of a 2-central involution as in the Mathieu group M24, is M24, L5(2) or a group of order 4.030.387.200. The first complete uniqueness proof for the latter case was given by L. Soicher in 1991. The generators and relations occurring here are easy to verify by a simple Todd–Coxeter algorithm. It is an easy task to get a new uniqueness and existence proof of the Held group from this result. Also basic facts like the Schur Multiplier or the automorphism group of the Held group follow f…
Targeting p53, hdm2, and CD19: vaccination and immunologic strategies.
2000
Peptides presented by class I major histocompatibility complex (MHC) molecules and derived from normal self-proteins that are expressed at elevated levels by cells from a variety of human (Hu) malignancies provide, in theory, potential target antigens for a broad-spectrum, cytotoxic T lymphocyte (CTL)-based immunotherapy of cancer and hematologic malignancies. However, as such tumor- and leukemia-associated self-proteins are also expressed at low levels in some types of normal tissues, such as thymus, spleen and lymphohemopoietic cells, these self-MHC-self-peptide complexes may also represent thymic and/or peripheral tolerogens, thereby preventing immune responses. This is particularly true…
Neuronal cell cycle: the neuron itself and its circumstances.
2015
Neurons are usually regarded as postmitotic cells that undergo apoptosis in response to cell cycle reactivation. Nevertheless, recent evidence indicates the existence of a defined developmental program that induces DNA replication in specific populations of neurons, which remain in a tetraploid state for the rest of their adult life. Similarly, de novo neuronal tetraploidization has also been described in the adult brain as an early hallmark of neurodegeneration. The aim of this review is to integrate these recent developments in the context of cell cycle regulation and apoptotic cell death in neurons. We conclude that a variety of mechanisms exists in neuronal cells for G1/S and G2/M check…
Study on ambient concentrations of PM10, PM10-2.5, PM2.5 and gaseous pollutants. Trace elements and chemical speciation of atmospheric particulates
2010
Abstract This study provides the first comprehensive report on mass concentrations of particulate matter of various sizes, inorganic and organic gas concentrations monitored at three sampling sites in the city of Palermo (Sicily, Italy). It also provides information on the water-soluble species and trace elements. A total of 2054 PM10 (1333) and PM2.5 (721) daily measurements were collected from November 2006 to February 2008. The highest mass concentrations were observed at the urban stations, average values being about two times higher than those at the suburban (control) site. Time variations in PM10 and also PM10–2.5 were observed at the urban stations, the highest concentrations being …
Different muscarinic receptor subtypes modulate proliferation of primary human detrusor smooth muscle cells via Akt/PI3K and map kinases.
2013
While acetylcholine (ACh) and muscarinic receptors in the bladder are mainly known for their role in the regulation of smooth muscle contractility, in other tissues they are involved in tissue remodelling and promote cell growth and proliferation. In the present study we have used primary cultures of human detrusor smooth muscle cells (HDSMCs), in order to investigate the role of muscarinic receptors in HDSMC proliferation. Samples were obtained as discarded tissue from men >65 years undergoing radical cystectomy for bladder cancer and cut in pieces that were either immediately frozen or placed in culture medium for the cell culture establishment. HDSMCs were isolated from samples, propagat…
Receptor phosphorylation does not mediate cross talk between muscarinic M(3) and bradykinin B(2) receptors.
1999
This study examined cross talk between phospholipase C-coupled muscarinic M3and bradykinin B2receptors coexpressed in Chinese hamster ovary (CHO) cells. Agonists of either receptor enhanced phosphoinositide signaling (which rapidly desensitized) and caused protein kinase C (PKC)-independent, homologous receptor phosphorylation. Muscarinic M3but not bradykinin B2receptors were also phosphorylated after phorbol ester activation of PKC. Consistent with this, muscarinic M3receptors were phosphorylated in a PKC-dependent fashion after bradykinin B2receptor activation, but muscarinic M3receptor activation did not influence bradykinin B2receptor phosphorylation. Despite heterologous phosphorylatio…
The non-neuronal cholinergic system in peripheral blood cells: Effects of nicotinic and muscarinic receptor antagonists on phagocytosis, respiratory …
2007
Peripheral blood cells express the complete non-neuronal cholinergic system. For example synthesis of acetylcholine and nicotinic as well muscarinic receptors have been demonstrated in leucocytes isolated from human peripheral blood. In the present experiments mononuclear cells and granulocytes were isolated from the peripheral blood to investigate content and synthesis of acetylcholine as well as phenotypic functions like respiratory burst, phagocytosis and migration. Mononuclear cells (T-cells and monocytes) contained 0.36 pmol/10(6) cells acetylcholine, whereas acetylcholine content in granulocytes was 100-fold lower. Acetylcholine synthesis amounted to 23.2+/-4.7 nmol/mg protein/h and 2…
Splittings of Toric Ideals
2019
Let $I \subseteq R = \mathbb{K}[x_1,\ldots,x_n]$ be a toric ideal, i.e., a binomial prime ideal. We investigate when the ideal $I$ can be "split" into the sum of two smaller toric ideals. For a general toric ideal $I$, we give a sufficient condition for this splitting in terms of the integer matrix that defines $I$. When $I = I_G$ is the toric ideal of a finite simple graph $G$, we give additional splittings of $I_G$ related to subgraphs of $G$. When there exists a splitting $I = I_1+I_2$ of the toric ideal, we show that in some cases we can describe the (multi-)graded Betti numbers of $I$ in terms of the (multi-)graded Betti numbers of $I_1$ and $I_2$.
On hyperbolic type involutions
2001
We give a bound on the number of hyperbolic knots which are double covered by a fixed (non hyperbolic) manifold in terms of the number of tori and of the invariants of the Seifert fibred pieces of its Jaco-Shalen-Johannson decomposition. We also investigate the problem of finding the non hyperbolic knots with the same double cover of a hyperbolic one and give several examples to illustrate the results.