Search results for "MAC"
showing 10 items of 24950 documents
Meccanismi antitumorali degli oli essenziali estratti da piante succulente in un modello di leucemia mielocitica acuta multifarmacoresistente
Contenido multimedia e interactivo H5P en la enseñanza: perspectiva del estudiantado de ramas de educación
2021
Moodle es una plataforma de aprendizaje gratuita creada en 2002. Según datos de noviembre de 2021 (Moodle, n.d.), España es el país del mundo que más utiliza esta plataforma educativa. En la versión de Moodle 3.9. (lanzada en 2020) y posteriores está disponible un nuevo tipo de contenido: los objetivos de aprendizaje multimedia e interactivos H5P. Hasta hace poco tiempo, la única manera de crear este tipo de contenido era con conocimientos avanzados de programación. Además, existían barreras relacionadas con el acceso al software, y la compatibilidad de los formatos y las plataformas. Hoy en día, estas limitaciones están desapareciendo gracias a H5P (abreviatura de paquete HTML5). H5P es so…
L'écriture des documents numériques : Approche ergonomique
2007
Cet ouvrage traite de la conception de documents numériques utilisés en contexte professionnel et étudie en particulier les deux thèmes suivants : le découpage de l'information pour la mise en écran, les organisateurs de structure, de navigation et de mise en relief de l'information. L'influence sur la lecture des dispositifs de mise en forme matérielle et des organisateurs de structure et de navigation est souvent méconnue. Aussi les méthodes destinées à tester le rôle des dispositifs de mise en forme revêtent-elles une importance capitale et sont présentées à la fin de cet ouvrage. Les spécificités des supports (document papier et document numérique) sont également abordées en termes de c…
Factors Influencing Teachers’ Use of ICT in Class: Evidence from a Multilevel Logistic Model
2022
Information and Communication Technologies (ICTs) have become a key factor in the educational context, especially in the aftermath of the COVID-19 pandemic, and, correctly implemented, can help to improve academic performance. The aim of this research was to analyse the factors that influence teachers’ decisions to use ICT more- or less frequently to carry out tasks and exercises in their classes. To this end, we estimated a multilevel logistic model with census data from the individualized evaluation of students of the Community of Madrid (Spain) carried out at the end of the 2018–2019 academic year in primary and secondary education. Additionally, we applied multiple imputation techniques…
Maxillary lesion presenting as a first sign of multiple myeloma : case report
2007
Plasma cell neoplasia is a lymphoid neoplastic proliferation of B cells. This denomination encloses multiple myeloma (MM), solitary bone plasmacytoma and extramedullary plasmacytoma. MM consists of a clonal proliferation of plasma cells based in the bone marrow, with various degrees of differentiation. Neoplastic cells usually produce great amounts of monoclonal light or heavy chains of immunoglobulin that can be detected in serum or urine. The disease is more frequently in men and the average age at diagnosis is about 60 years. The diagnosis is established by blood and urine exams and medullary biopsy. Patients may present renal failure, bone pain, fatigue, recurrent infections and nervous…
A dynamic multiple receptor conformations (MD-MRC) approach to enhance early enrichment in virtual screening. A case study on PPAR-alpha
2016
Female Oviposition Decisions and Their Impact on Progeny Life-History Traits
2008
An important factor affecting the life-history of an organism is parental investment in reproduction: reproductive decisions are almost invariably costly. Therefore, reproductive decisions should be beneficial in terms of increased offspring number or fitness. For example, egg laying decisions in many insects can influence resource availability of the offspring through changes in the larval density, and resource availability will have effects on many life-history traits. Here we studied whether female reproductive decisions affect offspring fitness in Callosobruchus maculatus seed beetles. Females laid more eggs on black-eye beans than on mung beans. However, when the difference in the surf…
Un approccio innovativo per la modellazione degli edifici in muratura intelaiata. Applicazione ad un caso di studio
2013
Le strutture in muratura intelaiata rappresentano una parte rilevante delle strutture esistenti e sono ancora largamente adottate come sistema strutturale per la costruzione di edifici residenziali, soprattutto in aree del mondo a forte sismicità non fortemente industrializzate e nelle quali la muratura rappresenta ancora un materiale tradizionale e a basso costo. In questo lavoro viene presentato un approccio per macro-elementi per la valutazione della risposta sismica di strutture in muratura confinata. La complessa interazione tra il telaio e la muratura è simulata mediante un approccio originale in cui il telaio è modellato con aste a plasticità concentrata mentre il contributo della mu…
The assessment of skeletal status in young patients with Turner syndrome by 2 densitometric techniques: Phalangeal quantitative ultrasound and dual e…
2018
Background. Studies using dual energy X-ray absorptiometry (DXA) demonstrate a reduction in bone mineral density (BMD) in children and adolescents with Turner syndrome (TS). However, these studies do not take into account changes in bone size, which influence BMD in the case of short-statured patients. Phalangeal quantitative ultrasound (phQUS) measurements have shown an ability to reveal changes due to skeletal growth, aging, and bone and mineral disorders. There is limited data on bone mineral status in girls with TS assessed by 2 different techniques, i.e., DXA and phQUS. Objectives. The aim of this study was to investigate the potential negative impact of TS on bone status and to assess…
Posttraumatic Propofol Neurotoxicity Is Mediated via the Pro–Brain-Derived Neurotrophic Factor-p75 Neurotrophin Receptor Pathway in Adult Mice*
2016
Objectives:The gamma-aminobutyric acid modulator propofol induces neuronal cell death in healthy immature brains by unbalancing neurotrophin homeostasis via p75 neurotrophin receptor signaling. In adulthood, p75 neurotrophin receptor becomes down-regulated and propofol loses its neurotoxic effect. H