Search results for "MAC"

La aproximación conductual a la transparencia contractual en los servicios financieros de crédito

2022

El deber de información se ha consagrado como la herramienta estrella del derecho contractual de consumo. Su proliferación a lo largo del ordenamiento jurídico es una realidad por pocos negada. Sin embargo, su utilización ha demostrado pocas evidencias de éxito. Lo que nos lleva a cuestionar la naturaleza de las premisas teóricas sobre las que se fundamenta. En especial, aquellas relacionadas con la imagen del consumidor medio adoptada tanto a nivel normativo como jurisprudencial. Con el presente artículo, pretendemos cuestionar la eficacia de los deberes de información como herramientas encaminadas a evitar la celebración de contratos con clausulado asimétrico.

Estudio cualitativo sobre las barreras y los factores facilitadores en la demanda de los Servicios Profesionales Farmacéuticos Asistenciales en las f…

2023

INTRODUCCIÓN Según estudios recientes, los Servicios Profesionales Farmacéuticos Asistenciales (SPFA) demostraron sus beneficios en la calidad de vida de pacientes y sistemas de salud. Los SPFA son actividades sanitarias prestadas desde la farmacia comunitaria (FC), para la prevención de enfermedades y la mejora de la salud mediante la optimización del uso y del resultado de los tratamientos. Sin embargo, en España existe un bajo porcentaje de farmacias comunitarias que ofrecen SPFA, a excepción de la dispensación, indicación farmacéutica, medida de parámetros clínicos, la educación/ información sanitaria y la formulación magistral ya arraigados en la profesión desde hace tiempo. OBJETIVO A…

Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum

2012

WOS: 000306752700042

Epigenetic regulation of sex differences in susceptibility to stress

2017

Under current diagnostics depression and stress related mood disorders have a higher occurrence in women than men. Little is known of the biological mechanisms contributing to these sex differences and how they may impact potential new therapeutics. Here we examine how DNA methylation contributes to sex specific stress vulnerability in adult animals. Mice of both sexes were exposed to variable stress and given a behavioral test battery to examine stress sensitivity. Female mice expressed depressionassociated behavior across all tests stress exposure whereas males were behaviorally resilient. Markers of pre and post-synaptic plasticity and spine morphology were examined using a combination o…

Effects of shallow hydrothermal vents on macroalgal communities

2011

Limits to Arbitrage and Interest Rates: a Debate Between Keynes, Hawtrey and Hicks

2018

International audience; This paper deals with a debate between Hawtrey, Hicks and Keynes concerning the capacity of the central bank to influence the short-term and the long-term rates of interest. Both Hawtrey and Keynes considered the central bank’s ability to influence short-term rates of interest. However, they do not put the same emphasis on the study of the long-term rates of interest. According to Keynes, long-term rates are influenced by future expected short-term rates (1930, 1936), whereas for Hawtrey (1932, 1937, 1938), long-term rates are more dependent on the business cycle. Short-term rates do not have much effect on long-term rates according to Hawtrey. In 1939, Hicks enters …

Polymeric nanoparticles for siRNA delivery: Production and applications

2017

Gene therapy through the use of siRNA and a polymeric carrier are becoming an efficient therapeutic option to conventional pharmaceutical formulations for the treatment of deadly diseases, such as cancer, pulmonary, ocular and neurodegenerative diseases. However, several considerations regarding the stability, formulation, and efficacy have to be faced up until these systems could be considered to be a marketable pharmaceutical products for to extend siRNA application to clinical practice. This review is focused on the key challenges of siRNA therapeutics, with special attention on the faced obstacles and on the formulation-related difficulties, providing a list of requirements needed for o…

Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.

2021

Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…

Inulin Derivatives Obtained Via Enhanced Microwave Synthesis for Nucleic Acid Based Drug Delivery

2015

A new class of therapeutic agents with a high potential for the treatment of different socially relevant human diseases is represented by Nucleic Acid Based Drugs (NABD), including small interfering RNAs (siRNA), decoy oligodeoxynucleotides (decoy ODN) and antisense oligonucleotides (ASOs). Although NABD can be engineered to be specifically directed against virtually any target, their susceptibility to nuclease degradation and the difficulty of delivery into target tissues severely limit their use in clinical practice and require the development of an appropriate nanostructured delivery system. For delivery of NABD, Inulin (Inu), a natural, water soluble and biocompatible polysaccharide, wa…

Valorization of Side Stream Products from Sea Cage Fattened Bluefin Tuna (Thunnus thynnus): Production and In Vitro Bioactivity Evaluation of Enriche…

2022

The valorization of side streams from fishery and aquaculture value-chains is a valuable solution to address one of the challenges of the circular economy: turning wastes into profit. Side streams produced after filleting of sea cage fattened bluefin tuna (Thunnus thynnus) were analyzed for proximate composition and fatty acid profile to evaluate the possibility of producing tuna oil (TO) as a valuable source of ω-3 polyunsaturated fatty acids (PUFA) and testing its bioactivity in vitro. Ethyl esters of total fatty acids (TFA), obtained from TO, were pre-enriched by urea complexation (PUFA-Ue) and then enriched by short path distillation (SPD) up to almost 85% of the PUFA fraction (PU…