Search results for "MACRO"
showing 10 items of 3471 documents
Actin in Allomyces arbuscula
1991
International audience; A 42 kDa protein was isolated by affinity chromatography on DNAse I-Sepharose from 24-h-old mycelia of Allomyces arbuscula. It was identified as actin by immunoblots with monoclonal antibody probe against a chicken gizzard actin. This fungal actin has a pI of 5.9 and separates into two spots on two-dimensional polyacrylamide gel electrophoresis, suggesting its dual nature. It can polymerize into 8-10 nm filaments visualized by electron microscopy.
A biometic olfactory based biosensor combining electrochemistry and odorant-binding
2012
A biometic olfactory based biosensor combining electrochemistry and odorant-binding. Food Factory 2012
Macroecology of Southern Ocean echinoids : distribution, biogeography and modelisation
2011
What are the forcing factors and main patterns of species distribution? This question is the core of macroecological issues and is of particular interest in the present context of global warming. The main objectives of this thesis were to determine the current distribution patterns of Antarctic and sub-Antarctic echinoid species at the scale of the whole Southern Ocean and to highlight the forcing factors that control them. The ecological niche modelling of 19 echinoid species showed that distribution is mainly structured in two patterns: (1) a first one represented by species that are not limited to the south of the Polar Front and distributed from the Antarctic coasts to the sub-Antarctic…
Role of heat shock protein HSP90 and HSP70 in macrophagic differentiation
2010
Heat shock proteins (HSPs) are molecular chaperones whose expression is increased after many different stresses. They have a protective function helping the cell to cope with lethal conditions. These proteins play an essential role as molecular chaperones by assisting the correct folding of nascent and stress-accumulated misfolded proteins and by preventing their aggregation. My team is interested in understanding the roles of HSPs in two physiological related processes: apoptosis and cell differentiation. The aim of my work is to study the functions of HSP90 and HSP70 in macrophagic differentiation. I first studied the role of HSP90 in macrophagic differentiation. We previously reported th…
TRAIL signalling regulation by ezrin
2011
Background and Aim: TRAIL has sparked a growing interest in oncology due to its ability to selectively trigger cancer cell death while sparing normal cells. The Fas/actin association through ezrin, a member of the ERM protein family, has been reported to regulate early steps of Fas-mediated apoptosis. In this project, we addressed the role of ezrin regarding TRAIL-induced cell death in B lymphoma cell lines, or adherent cancer cell lines (HeLa WT, HCT116, SW480). Methods: Molecular and biochemical approaches were employed to study the relevance of ezrin and its phosphorylation status in TRAIL signaling. Results: We found that ezrin displays a negative function towards TRAIL- and Fas-mediate…
Microglia and α-synuclein implication in Parkinson's disease
2011
Age-related neurodegenerative disorders like Parkinson’s disease take an enormous toll on individuals and on society. Despite extensive efforts, Parkinson’s disease remains incurable and only very limited treatments exist. Indeed, Parkinson’s pathogenesis is still not clear and research on its molecular mechanisms is ongoing. In this study, we focused our interest on two abnormal events occurring in Parkinson’s patients, namely α-synuclein aggregation and microglial activation. We first investigated α-synuclein and its abnormal polymerisation. For this purpose, we developed novel methods, which allowed the in vitro production of different types of α-synuclein oligomers. Using highly sensiti…
Comparaison des réponses de l'Indice Biologique Macrophytique en Rivière et d'autres indices hydrobiologiques.
2005
National audience
Utilisation en grand cours d'eau de l'Indice Biologique Macrophytique en Rivière. Comparaison avec une approche typologique, mise en évidence des per…
2004
Utilisation en grand cours d'eau de l'Indice Biologique Macrophytique en Rivière. Comparaison avec une approche typologique, mise en évidence des perturbations du profil longitudinal. Colloque AFL
Evaluation des flux de pesticides dans les systèmes de culture innovants : forçage du modèle de simulation du devenir des pesticides MACRO avec le mo…
2015
Evaluation des flux de pesticides dans les systèmes de culture innovants : forçage du modèle de simulation du devenir des pesticides MACRO avec le modèle de culture STICS. 45e Congrès du Groupe Français des Pesticides "Devenir et impact des pesticides : verrous à lever et nouveaux enjeux. 45e Congrès du Groupe Français des Pesticides
Evaluation of the environmental fate and ecotoxicological impact of the pesticide chlorpyrifos in soil for improvement of its environmental risk asse…
2016
EABIOMEUBINRA; Pesticides protect crops from various pests but can also harm nontarget organisms. To minimize risks for the environment and human health, a huge amount of studies are carried out and evaluated during the authorization process of each pesticide. However, the prediction of the environmental fate and ecotoxicological impact of a pesticide remains difficult. Several 100 formerly used pesticides are now banned because unexpected risks emerged decades after their authorization. Risk assessment documents of the organophosphate insecticide chlorpyrifos (CHL) particularly lack information about its degradation and potential transformation products in soil, and its impact on non-targe…