Search results for "MAD"

Docosahexaenoic acid reduces suppressive and migratory functions of CD4CD25 regulatory T-cells

2009

Immunological tolerance is one of the fundamental aspects of the immune system. The CD4(+)CD25(+) regulatory T (Treg) cells have emerged as key players in the development of tolerance to self and foreign antigens. However, little is known about the endogenous factors and mechanisms controlling their suppressive capacity on immune response. In this study, we observed that docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, diminished, in a dose-dependent manner, the capacity of Treg cells to inhibit the CD4(+)CD25(-) effector T-cell proliferation. DHA not only reduced the migration of Treg cells toward chemokines but also downregulated the mRNA expression of CCR-4 and CXCR-4 in Tr…

CCL5(RANTES) inhibits TGFbeta1 induced collagen production in human bronchial epithelial cells by action of Smad protein

2009

Airway epithelial cells modulate bronchial remodelling in COPD and asthma. TGF-β1 up-regulation was observed in the bronchial epithelial cells of asthmatics and COPD patients. TGF-β is involved in airways remodelling mainly acting via the Smad pathway. Increased CCL5 was also observed in bronchi of patients with severe COPD. We investigated the effects of TGF-β1 on collagen type I, Smad 3-4 and 7 expression and the effects of CCL5 on TGF-β1-induced collagen production in human bronchial epithelial cells (16HBE).Cells were treated with 10ng/ml of TGF-β1, 10ng/ml of CCL5 and 10ng/ml of both TGF-β1 and CCL5 for 0,3 and 24 hours.TGF-b1 increased Smad3,Smad4 and collagen type I(p=0.0472, p=0.043…

"Diagnoosin paikka. Naisten kertomuksia psykiatrian potilaiksi tulemisesta"

2006

Transformando las prácticas de evaluación en las agencias de innovación para fomentar transiciones hacia la sostenibilidad

2019

The aim of the study is to identify different styles and practices for evaluation of innovation policies based on different orientations, focusing on the case of the paradigm of transformative change to foster transitions towards sustainability, and the problems associated with its application. The study is exploratory, and it uses public funding agencies for innovation as strategic research settings. Based on the information provided by the experience of an international consortium participated by funding agencies from different countries, the main concepts and problems presented in the theoretical debate are illustrated. Finally, the main contributions of the study to the theory and pract…

¿Cabe hablar de una «generación de la crisis»? Discusión en torno a una noción sobreexplotada

2018

This article states that nowadays there is an overuse (or a misuse) of the «Generation» idea. The discussion among many authors over the «Generation of crisis» concept suggests that it is useful to outline the characteristics of the target of population of the collective of youth who are mainly affected by the economic and social crisis over the past years. Nevertheless, through analyzing the meanings of the «Generation of Crisis» made by Mannheim, Ortega and other classic authors, it is clear that the social class approach together with the generational one are needed to define this concrete concept. The conclusion of the articleis that both approaches are seen as underpinning their utilit…

Noticia de las funciones, y regocijos, que se han executado en la Villa, y Corte de Madrid à la feliz entrada que ha hecho el dia 10. de octubre nues…

Títol pres d'inici de text Peu d'impremta pres del colofó Precedeix al títol: [Creu de Malta L'any 1746 és el de l'esdeveniment, segons consta a l'índex ms Caplletra ornada al començament del text i vinyeta al final

Behaviour of sediment-associated silver nanoparticles and their toxicity to Lumbriculus variegatus

2017

The increasing use of silver nanoparticles (AgNPs) in industry and consumer products results in the increasing environmental concentrations of AgNPs. In the aquatic environment, sediment is the major sink for the AgNPs. The behaviour and toxicity of AgNPs in sediments is largely unknown, and therefore the potential risk to the benthic ecosystems is difficult to predict. The aim of this thesis was to study the toxicity and uptake of uncoated AgNPs (uc-AgNPs) and polyvinylpyrrolidone-coated AgNPs (PVP-AgNPs) to Lumbriculus variegatus in sediment exposures. Also, the association of AgNP-originated dissolved Ag with sediment components was studied using a sequential extraction method. Studies w…

Aislamiento y caracterización de distintas poblaciones celulares en el tejido adiposo humano

2015

Las células madre adultas, han sido empleadas en numerosos procedimientos de terapia clínica, ya que no desencadenan rechazo inmunológico y tampoco presentan problemas éticos relacionados con su uso. El tejido adiposo, constituye una fuente idónea para la extracción de células madre mesenquimales, debido a su abundancia y al bajo riesgo quirúrgico que conlleva su extracción. El peligro de transmisión de zoonosis que existe al emplear reactivos de origen animal en el procesamiento y cultivo de células humanas que podrían llegar a ser trasplantadas a pacientes, produjo que nos planteásemos sustituir reactivos animales empleados en los procedimientos tradicionales, por otros de origen humano o…

MECHANISMS OF CHROMOSOMAL INSTABILITY: RELATIONSHIP BETWEEN TUMOR SUPPRESSORS AND SAC GENES

2017

Caratteristica comune di molti tumori solidi è l’aneuploidia, conseguenza dell’instabilità cromosomica (CIN). Tuttavia non sono ancora chiari i meccanismi alla base dell’aneuploidia e i percorsi che permettono la sua tolleranza. Lo Spindle Assembly Checkpoint (SAC) è un meccanismo di sorveglianza cellulare che controlla la stabilità genomica durante la mitosi. Alterazioni nei membri del SAC generano aneuploidia, ma non è ancora chiaro se questi difetti sono sufficienti per promuovere la tumori-genesi. In questo processo, infatti, il contesto genetico della cellula gioca un ruolo importante. È risaputo che i difetti di p53 aiutano le cellule a proliferare velocemente tollerando la CIN. Al co…

Growth and differentiation factor 11 (GDF11): Functions in the regulation of erythropoiesis and cardiac regeneration

2015

International audience; Members of the TGF-β superfamily transduce their signals through type I and II receptor serine/threonine kinases. The binding of activins to activin type IIA (ActRIIA) or type IIB (ActRIIB) receptors induces the recruitment and phosphorylation of an activin type I receptor (ALK4 and/or ALK7), which then phosphorylates the Smad2 and Smad3 intracellular signaling proteins. The regulation of members of the TGF-β family is known to be complex, because many proteins able to bind the ligands and inhibit their activities have been identified. Growth and differentiation factor 11 (Gdf11) belongs to the TGF-β family. GDF11, like other members of the TGF-β superfamily, is prod…