Search results for "MAG"

Choroidal thickness in glaucoma patients and glaucoma suspects measured by spectral domain coherence optical tomography

2012

Purpose: The aim of our study was to evaluate and compare retro-foveolar choroidal thickness (RFCT) of healthy subjects, individuals with intraocular hypertension, patients with primary open-angle glaucoma (POAG), patients with normal tension glaucoma (NTG) and patients with primary angle-closure glaucoma (PACG) by spectral domain optical coherence tomography (SD-OCT).Methods: Sixty-five healthy eyes, 30 eyes with intraocular hypertension, 90 eyes with POAG, 30 eyes with NTG and 20 eyes with PACG were included in this cross-sectional study. RFCT, foveolar retinal thickness and average retinal nerve fiber layer thickness (RNFL) were measured by SD-OCT (Spectralis HRA-OCT, Heidelberg Engineer…

Novel VAMPIRE algorithms for quantitative analysis of the retinal vasculature

2013

This paper summarizes three recent, novel algorithms developed within VAMPIRE, namely optic disc and macula detection, arteryvein classification, and enhancement of binary vessel masks, and their performance assessment. VAMPIRE is an international collaboration growing a suite of software tools to allow efficient quantification of morphological properties of the retinal vasculature in large collections of fundus camera images. VAMPIRE measurements are currently mostly used in biomarker research, i.e., investigating associations between the morphology of the retinal vasculature and a number of clinical and cognitive conditions.

Anatomical and functional macular changes after rhegmatogenous retinal detachment with macula off

2011

International audience; Purpose: To evaluate the correlation between morphologic changes in the outer retina and visual function after successful repair of rhegmatogenous retinal detachment with macula off. Methods: Thirty patients (30 eyes) with successful repair of rhegmatogenous retinal detachment (RD) after macula off and a minimum 6-month follow-up after the surgery were examined. Preoperative characteristics of the RD (visual acuity and duration) were collected. Postoperative visual acuity measurement with ETDRS scale and fundus autofluorescence (FAF) were performed. Spectral-Domain Optical Coherence Tomography (HRA OCT) of outer retina was performed to analyse the number of disrupted…

On the use of multi-temporal series of COSMO-SkyMed data for LANDcover classification and surface parameter retrieval over agricultural sites

2011

The objective of this paper is to report on the activities carried out during the first year of the Italian project “Use of COSMO-SkyMed data for LANDcover classification and surface parameters retrieval over agricultural sites” (COSMOLAND), funded by the Italian Space Agency. The project intends to contribute to the COSMO-SkyMed mission objectives in the agriculture and hydrology application domains.

The success of Agronomy for Sustainable Development: from IF 0.566 rank 29/53 to IF 2.9 rank 4/75

2012

Scientific journals are facing an increasing competition directly impacting publishers and editorial boards. In addition, access to scientific information and reading patterns have deeply changed. From 2003 the journal Agronomy for Sustainable Development (ASD) has adapted its editorial policy to this highly competitive and moving environment in order to stand out and improve its impact (1). The scope, language and title of the journal were modified. A preselection step was introduced, several calls for reviews were made and spin-off books were published (2). Particular attention was given to abstracts, titles, colour figures and photos. A sister book series named Sustainable Agriculture Re…

Late Activation of Stress-activated Protein Kinases/c-Jun N-terminal Kinases Triggered by Cisplatin-induced DNA Damage in Repair-defective Cells

2011

Although stress-activated protein kinases/c-Jun N-terminal kinases (SAPK/JNK) are rapidly activated by genotoxins, the role of DNA damage in this response is not well defined. Here we show that the SEK1/MKK4-mediated dual phosphorylation of SAPK/JNK (Thr-183/Tyr-185) correlates with the level of cisplatin-DNA adducts at late times (16–24 h) after drug treatment in both human and mouse cells. Transfection of platinated plasmid DNA also caused SAPK/JNK activation. A defect in transcription-coupled nucleotide excision repair resting on a mutation in Cockayne syndrome group B protein promoted the late SAPK/JNK activation following cisplatin exposure. Signaling to SAPK/JNK was accompanied by act…

Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors

2016

Novel rhodesain inhibitors were developed by combining an enantiomerically pure 3-bromoisoxazoline warhead with a 1,4-benzodiazepine scaffold as specific recognition moiety. All compounds were proven to inhibit rhodesain with Ki values in the low-micromolar range. Their activity towards rhodesain was found to be coupled to an in vitro antitrypanosomal activity, with IC50 values ranging from the mid-micromolar to a low-micromolar value for the most active rhodesain inhibitor (R,S,S)-3. All compounds showed a good selectivity against the target enzyme since all of them were proven to be poor inhibitors of human cathepsin L. Novel rhodesain inhibitors were developed by combining an enantiomeri…

Lesiones de hemisferio derecho. Materiales y análisis pragmático (Volumen VII del corpus PerLA).

2011

El corpus PerLA (“Percepción, Afasia y Lenguaje”), surge en el área de Lingüística General de la Universitat de València como respuesta a la necesidad de integrar el estudio de las patologías lingüísticas en las tendencias actuales de la pragmática y la lingüística de corpus. En esta ocasión se presentan seis transcripciones en las que participa un hablante con lesión cerebral de hemisferio derecho, una situación que ha sido poco investigada desde planteamientos lingüístico-logopédicos, y para la que la bibliografía suele proponer síntomas de escaso alcance verbal, como la disprosodia o la agnosia visual. No obstante, el análisis detenido de los datos ecológicos permite comprobar la alterac…

La resistibile ascesa del risarcimento punitivo nell’ordinamento italiano (a proposito dell’ordinanza n. 9978/2016 della Corte di Cassazione)

2017

L'ERNIAZIONE DELLE GHIANDOLE LACRIMALI IN PAZIENTI CON OFTALMOPATIA DI GRAVES: UN POSSIBILE MARKER DI ATTIVITÀ DELLA MALATTIA.

2018

Scopo Il coinvolgimento delle ghiandole lacrimali (GL) in pazienti affetti da Oftalmopatia di Graves (OG) è stato considerato come una potenziale causa dei sintomi tipicamente associati a questa malattia. Diversi studi hanno rilevato che le dimensioni delle GL nei pazienti OG sono aumentate, ma non ci sono studi che prendono in considerazione pazienti con diversa attività della malattia. Abbiamo valutato l'erniazione delle GL rilevata sulle immagini di risonanza magnetica (RM), in pazienti con diversa attività OG. Materiale e metodi Trentadue pazienti (10M, 22F, età media 49,5 anni, range 30-68) con OG sono stati arruolati e raggruppati in base all'attività della malattia (A: n = 16 co…