Search results for "MAI"

Radzenes epitēlija strukturālās izmaiņas mīksto kontaktlēcu lietotājiem

2021

Darbs ir uzrakstīts latviešu valodā uz 38 lapaspusēm. Tas satur 19 attēlus, 8 tabulas, 56 atsauces uz literatūras avotiem. Darba mērķis: noskaidrot mīksto kontaktlēcu ietekmi uz radzenes epitēlija biezuma kartējumu. Metode: 63 dalībniekiem (126 acis) vecumā no 18 līdz 44 gadiem tika iegūts radzenes epitēlija biezuma kartējums, veicot radzenes skenēšanu ar spektrālā domēna optiskās koherences tomogrāfu Maestro 3D (Topcon). Rezultāti: Pētījumā tika noskaidrots, ka visiem dalībniekiem radzenes epitēlijs ir biezāks centrā, un jaunākās paaudzes mīkstās kontaktlēcas nerada radzenes epitēlija biezuma izmaiņas, neatkarīgi no kontaktlēcu materiāla (hidrogēla / silikonhidrogēla) un valkāšanas modalit…

Adopcijas iespējas Latvijā.

2021

Darba tēma ir “Adopcijas iespējas Latvijā”. Autore darba tēmas izvēlē un izstrādē balstījās uz to, ka adopcija ir bijusi un būs aktuāla tēma. Adopcija sāk kļūt aktuāla lielai daļai sabiedrības iedzīvotāju, jo viņi ar mūsdienu dzīves stilu, kā, piemēram, smēķēšanu jau no agra vecuma, biežu alkohola lietošana pārmērīgā daudzumā, narkotiskajām vielām vai citām apreibinošām vielām, sāk lēnām zaudēt spēju būt auglīgiem. Adopcija ir risinājums kļūt par vecākiem. Bakalaura darba mērķis ir adopcijas procesa izpēte, un viendzimuma partnerattiecību problēmas adopcijas procesā. Darba uzdevumi ir izpētīt kā notiek adopcijas process, iepazīties ar aktuālākajām problēmām, kas var rasties adopcijas proces…

Une vigne gallo-romaine de plaine à Gevrey-Chambertin (Côte-d'Or), Ier-IIe s. ap. J.-C.. Implications pour le développement des terroirs viticoles de…

2011

Recent excavations at Au-dessus de Bergis in Gevrey-Chambertin (Côte-d’Or, Burgundy) brought to light numerous, rectangular aligned pits interpreted as an ancient vineyard dated from the end of the 1st/mid-2nd century to the 3rd century AD. The vineyard is largely extent in area and was bounded to the south by a hedge or fence. It was composed of parallel rows that may have been trained over and along high, inclined wooden frames. Vine stocks were renewed by layering, over several generations of plants, according to some agricultural wine-growing techniques recommended by Latin agronomists. This vineyard attests to the establishment of vineyards from the mid-1st century AD in places differe…

Ranta-asumisen ulottuvuuksia : asuinympäristön merkitys asukkaiden viihtyvyydelle Jyväskylän Lutakossa ja Ainolanrannassa

2005

Se kehittyy, mitä kehitetään : viisaus kokemustietona ja itsekasvatuksessa

2019

KKO 2022:9 Voiko maalittaminen olla vainoamista?

2022

KKO:2022:9-tulkinta vastaa moniin niihin huoliin ja tilanteisiin, joita maalittamisen kriminalisointia koskevissa esityksissä mainittiin. Silti kaikki virkamieheen tai viranomaiseen kohdistunut palaute ei voi olla rangaistavaa, vaikka se olisi voimakastakin. Sähköpostin ja sosiaalisen median kanavien käyttö on johtanut siihen, että arvostelua annetaan helpommin, jos yksittäiset ratkaisut tai toimet herättävät keskustelua ja kritiikkiä. Rangaistava vainoaminen edellyttää toistuvia samaan henkilöön kohdistuvia tekoja. Yksittäiseen tapahtumaan liittyvä arvosteluryöppy ei ole vainoamista, jos se tulee toisistaan erillisiltä ja riippumattomilta tahoilta, kirjoittaa OTT, dosentti Riitta Ollila Ed…

Damping Provision by Different Virtual Synchronous Machine Schemes

2020

The adoption of virtual synchronous machine (VSM) schemes for the control of power converters is gaining more and more attention both in academia and industry. The VSM control strategies fall into the category of grid-forming converter controls, and they are intended for a range of different applications, providing specific services and different kinds of support to the grid. The paper investigates the possibility of damping provision to the system by VSM power converters. Different schemes are considered and compared, showing the opportunity of the investigated solutions through combined modal and time domain analyses. A specific modification of the power synchronization loop is recognized…

Conformational Dynamics of the Dengue Virus Protease Revealed by Fluorescence Correlation and Single-Molecule FRET Studies.

2021

The dengue virus protease (DENV-PR) represents an attractive target for counteracting DENV infections. It is generally assumed that DENV-PR can exist in an open and a closed conformation and that active site directed ligands stabilize the closed state. While crystal structures of both the open and the closed conformation were successfully resolved, information about the prevalence of these conformations in solution remains elusive. Herein, we address the question of whether there is an equilibrium between different conformations in solution which can be influenced by addition of a competitive inhibitor. To this end, DENV-PR was statistically labeled by two dye molecules constituting a FRET …

Human Papillomavirus Types 16, 18, and 31 Share Similar Endocytic Requirements for Entry

2013

ABSTRACT Human papillomavirus type 18 (HPV18), one of the HPVs with malignant potential, enters cells by an unknown endocytic mechanism. The key cellular requirements for HPV18 endocytosis were tested in comparison to those for HPV16 and -31 endocytoses. HPV18 (like HPV16 and -31) entry was independent of clathrin, caveolin, dynamin, and lipid rafts but required actin polymerization and tetraspanin CD151, and the viruses were routed to the same LAMP-1-positive compartment. Hence, the viruses shared similar cellular requirements for endocytic entry.

Impact of VP1-Specific Protein Sequence Motifs on Adeno-Associated Virus Type 2 Intracellular Trafficking and Nuclear Entry

2012

ABSTRACT Adeno-associated virus type 2 (AAV2) has gained much interest as a gene delivery vector. A hallmark of AAV2-mediated gene transfer is an intracellular conformational change of the virus capsid, leading to the exposure of infection-relevant protein domains. These protein domains, which are located on the N-terminal portion of the structural proteins VP1 and VP2, include a catalytic phospholipase A 2 domain and three clusters of basic amino acids. We have identified additional protein sequence motifs located on the VP1/2 N terminus that also proved to be obligatory for virus infectivity. These motifs include signals that are known to be involved in protein interaction, endosomal sort…