Search results for "MALADIE"
showing 10 items of 135 documents
Abdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome
2014
Background: Abdominal infections are frequent causes of sepsis and septic shock in the intensive care unit (ICU) and are associated with adverse outcomes. We analyzed the characteristics, treatments and outcome of ICU patients with abdominal infections using data extracted from a one-day point prevalence study, the Extended Prevalence of Infection in the ICU (EPIC) II.Methods: EPIC II included 13,796 adult patients from 1,265 ICUs in 75 countries. Infection was defined using the International Sepsis Forum criteria. Microbiological analyses were performed locally. Participating ICUs provided patient follow-up until hospital discharge or for 60 days.Results: Of the 7,087 infected patients, 1,…
Nuclear rDNA-based molecular clock of the evolution of Triatominae (Hemiptera : Reduviidae), vectors of Chagas disease
2000
The evolutionary history and times of divergence of triatomine bug lineages are estimated from molecular clocks inferred from nucleotide sequences of the small subunit SSU (18S) and the second internal transcribed spacer (ITS-2) of the nuclear ribosomal DNA of these reduviids. The 18S rDNA molecular clock rate in Triatominae, and Prosorrhynchan Hemiptera in general, appears to be of 1.8% per 100 million years (my). The ITS-2 molecular clock rate in Triatominae is estimated to be around 0.4-1% per 1 my, indicating that ITS-2 evolves 23-55 times faster than 18S rDNA. Inferred chronological data about the evolution of Triatominae fit well with current hypotheses on their evolutionary histories…
Effects of mutations of wild-type alpha-synuclein on its structure and dimerization and consequences for the Parkinson's disease : answers from coars…
2022
Alpha-synuclein is a protein of 140 amino acids, intrinsically disordered and found abundantly in the brain and whose toxic aggregation there is the hallmark of the Parkinson's disease.The aim of the thesis is to understand the effects of certain mutations on the dimerization of alpha-synuclein and to contribute to understand its involvement in Parkinson's disease by using coarse-grained molecular dynamics. Coarse-grained molecular dynamics trajectories were computed using the UNited-RESidue (UNRES) program and provided unprecedented sampling (over an effective time of the order of milliseconds) of the alpha-synuclein structures in monomeric and dimeric forms. These data were generated both…
Intérêt des méthodes alternatives dans l’évaluation du médicament dans les populations particulières
2020
Well conducted randomized clinical trial is considered gold standard in drug safety and efficacy evaluation. Drug development can be challenging in rare diseases, or in ethically sensitive populations (pregnant women, children, patient with cognitive defect), because of low number of subjects. The low rate of observed events at a sample scale in this population can lead to a biased evaluation of drugs compared to the general population. The aim of this work was to address alternative methods for drug evaluation in particular populations, especially pharmaco-epidemiology on populational database of the SNDS (Système National des Données de Santé). We first evaluate the safety of anti-TNFα in…
Localized versus systemic effect of arbuscular mycorrhizal fungi on defence responses to Phytophthora infection in tomato plants
2002
Development of biological control for plant diseases is accepted as a durable and environmentally friendly alternative for agrochemicals. Arbuscular mycorrhizal fungi (AMF), which form symbiotic associations with root systems of most agricultural, horticultural and hardwood crop species, have been suggested as widespread potential bioprotective agents. In the present study the ability of two AMF (Glomus mosseae and Glomus intraradices) to induce local or systemic resistance to Phytophthora parasitica in tomato roots have been compared using a split root experimental system. Glomus mosseae was effective in reducing disease symptoms produced by P. parasitica infection, and evidence points to …
Une relation trophique originale : la vection entomophile d'agents pathogènes
2013
Bgpi : équipe 6 chapitre 34; Une relation trophique originale : la vection entomophile d'agents pathogènes
Implantations, activités et relations des établissements d'assistance en Bourgogne à la fin du Moyen Age
2012
The study presented here is the conclusion of an inventory about hospitals having existed on the territory of some dioceses (Autun, Auxerre, Chalon-sur-Saône, Nevers and the south of that of Langres diocese) between XIIth and XVth centuries. Based on the data collected, an atlas of assistance and a directory of sources on medieval hospitals of the study area has been made. The compiled informations proved to be very different but also very heterogeneous. Nevertheless, reflexions were conducted about the characteristics of these hospitals and their relationships with their economic, religious, political and social environments. It revolves around three parts dealing by turns the influence of…
La CGT et l’expérience du Front populaire. Vers une meilleure protection sanitaire des travailleurs
2011
International audience; Notre article se propose d’aborder une question méconnue de l’histoire sociale, celle de l’action de la CGT en faveur de l’amélioration des conditions sanitaires des ouvriers, en collaboration avec le gouvernement de Front populaire. Mêlant expertise médicale autonome et politique de présence, la CGT inaugure durant cette courte période une nouvelle forme d’action revendicative principalement axée sur les maladies professionnelles qui demeuraient jusqu’alors les grandes absentes du combat syndical.
Retour sur les accidents de mission
2019
International audience; Note sous CA Paris, 17 mai 2019, n° 16/08787
De l'inégalité sociale devant la santé au dualisme sanitaire : le RMI, une réponse adéquate aux besoins de santé des plus défavorisés ?
1993
Literature on household medical expenditure according to socio economiccategories indicates that that disparities in access to health care are no longer a major obstacle to social equality. Nevertheless these surveys do not take into account the dualistic structure of society and therefore do not recognise the changing issues in health and social policy. As regards health policy the issues are set in terms of the exclusion of those individuals who since they live on the fringes of economic activity no longer qualify for Social Security benefits. To give a complete picture of social inequalities it is essential to study this exclusion from health care. By studying the people who are on "RMI"…