Search results for "MAM"
showing 10 items of 1679 documents
Efficacy of emamectin benzoate in the control of Argulus coregoni (Crustacea: Branchiura) on rainbow trout Oncorhynchus mykiss.
2004
Efficacy of in-feed treatment with emamectin benzoate (Slice) for the control of ectoparasitic Argulus coregoni on rainbow trout Oncorhynchus mykiss was tested under laboratory and field conditions. In both experiments fish were fed with fish feed to deliver a therapeutic dose of 0 (control) or 50 microg emamectin benzoate kg(-1) d(-1) (treatment) for a period of 7 d. After 3 d of challenge with A. coregoni in the laboratory, the infestation level in treated fish was lower than that observed in the controls (p0.001). Efficacy of 100% against newly hatched A. coregoni metanauplii and adults and 80% against juveniles was observed. In the field, trial medication was undertaken at 2 sections on…
Computer-Aided Diagnosis System with Backpropagation Artificial Neural Network—Improving Human Readers Performance
2016
This article presents the results of a study into possibility of artificial neural networks (ANNs) to classify cancer changes in mammographic images. Today’s Computer-Aided Detection (CAD) systems cannot detect 100 % of pathological changes. One of the properties of an ANN is generalized information —it can identify not only learned data but also data that is similar to training set. The combination of CAD and ANN could give better result and help radiologists to take the right decision.
Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2
2009
Here we show that the cytosine-5 methyltransferase DNMT2 controls retrotransposon silencing in Drosophila somatic cells. In Drosophila, significant DNMT2-dependent DNA methylation occurs during early embryogenesis. Suppression of white gene silencing by Mt2 (Dnmt2) null mutations in variegated P[w(+)] element insertions identified functional targets of DNMT2. The enzyme controls DNA methylation at retrotransposons in early embryos and initiates histone H4K20 trimethylation catalyzed by the SUV4-20 methyltransferase. In somatic cells, loss of DNMT2 eliminates H4K20 trimethylation at retrotransposons and impairs maintenance of retrotransposon silencing. In Dnmt2 and Suv4-20 null genotypes, re…
Invasion of thehobo transposable element studied byin situ hybridization on polytene chromosomes ofDrosophila melanogaster
1994
The invasion kinetics of hobo transposable element in the Drosophila melanogaster genome was studied by in situ hybridization on the polytene chromosomes. Six independent lines of Drosophila melanogaster flies that had been previously transformed by microinjection of the pHFL1 plasmid containing a complete hobo element were followed over 50 generations. We observed that hobo elements were scattered on each of the chromosome arms, with more insertion sites on the 3R arm. The total number of insertion sites remains quite small, between four and six, at generation 52. On the 2R arm, a short inversion appeared once at generation 52. Most of the integration sites reported here were already descr…
PGal4 excision reveals the pleiotropic effects of Voila, a Drosophila locus that affects development and courtship behaviour
2001
0016-6723 (Print) Journal Article Research Support, Non-U.S. Gov't; In Drosophila melanogaster, the PGal4 transposon inserted at the chromosomal site 86E1-2 is associated with the Voila1 allele that causes multiple phenotypes. Homozygous Voila1/1 flies rarely reach adulthood and heterozygous Voila1/+ adult males display strong homosexual courtship behaviour. Both normal behavioural and developmental phenotypes were rescued by remobilizing the PGal4 element. Yet, the rescue of heterosexual courtship and of adult viability did not occur in the same strains, indicating that these defects have different genetic origins. Furthermore, many strains showed a partial rescue of both characters. Molec…
Comparative toxicity and cell-tissue distribution study on nanoparticular iron complexes using avian embryos and HepG2-cells
2007
In this study the toxicity and intracellular availability of iron from iron dextran (FeD), iron sucrose (FeS), and iron gluconate (FeG) was compared in organs of avian (turkey) embryos and in isolated cells (HepG2) in cell culture. Iron uptake was more pronounced in embryonic liver than in renal tissue. Cellular iron uptake in liver and kidney was more or less similar for the different compounds. Only some experiments showed slightly greater iron concentrations in liver and kidney with FeG compared with FeD and FeS. Significant differences were found in the survival ratios of the eggs and the embryo weights depending on the type of iron complex administered. The rank order of toxicities was…
Caracterización de la función inmunitaria y plaquetaria en mamíferos marinos y sus alteraciones inducidas por el estrés, patologías o contaminantes m…
2021
El ecosistema marino está siendo sometido de forma incesante a la influencia humana. Los mamíferos marinos, al ser animales longevos que se encuentran en lo alto de la cadena alimentaria son buenos bioindicadores del estado del medio marino. Entre los impactos que más afectan a los mamíferos marinos de vida libre se encuentran la contaminación química, física y acústica, la pesca accidental y el calentamiento global. Diversos estudios han demostrado la presencia de contaminantes en los tejidos de mamíferos marinos varados. Por otro lado, algunos estudios han demostrado la presencia en el agua del mar de xenobióticos que todavía no se han analizado en los tejidos de los mamíferos marinos has…
Utilidad del ganglio centinela en el cáncer de mama para disminuir la agresividad quirúrgica
2019
La afectación ganglionar se ha considerado hasta el momento un factor relevante para la supervivencia, estadiaje y tipo de tratamiento de las pacientes diagnosticadas de cáncer de mama. Se define al ganglio centinela (GC) como el primer ganglio de una cadena linfática que recibe el flujo linfático desde el tumor primario. Si este ganglio no contiene células tumorales es poco probable que el resto de ganglios axilares presenten enfermedad metastásica (1). La identificación del ganglio centinela puede sustituir a la linfadenectomía axilar para el estudio de extensión regional en el cáncer de mama, evitando su morbilidad asociada (2). Hoy en día, está aceptada la realización de la biopsia sel…
Perfil genético, epigenético e inmunohistoquímico en los cánceres de mama esporádicos y hereditarios
2016
El cáncer de mama (CM) es una de las principales causas de muerte por cáncer en la mujer en todo el mundo. En la actualidad el CM se entiende como una enfermedad heterogénea que abarca una serie de entidades definidas por sus diferentes características biológicas y comportamientos clínicos. Todo ello ha llevado a la búsqueda de biomarcadores que, a nivel individual o en combinación con otros marcadores (perfiles), ofrezcan a una mayor precisión diagnóstica, en el comportamiento evolutivo y en la predicción de la respuesta terapéutica. El presente estudio considera como mecanismo etiopatogénico de referencia del CM las mutaciones en los genes supresores tumorales BRCA1 y BRCA2, característic…
Tumor de células granulares de piel mamaria : Estudio morfológico de dos casos mostrando inmunorreactividad frente a-inhibina
2003
Introducción: El tumor de células granulares (TCG) es una lesión infrecuente en la mama, representando solo el 6-8% de los TCG, comprometiendo a menudo a la piel mamaria. Pacientes y métodos: Se revisa la casuística de TCG mamarios del Hospital Universitario La Fe de Valencia en un período de 19 años, con un total de 8000 especímenes biópsicos mamarios con 2200 diagnósticos de cáncer, realizando de forma retrospectiva un estudio morfológico (óptico, inmunohistoquímico y ultraestructural) a partir de material incluido en parafina. Resultados: Se detectan dos casos de TCG con afectación de piel mamaria con distinta presentación clínica (TCG como nódulo tumoral único y TCG como lesión tumoral …