Search results for "MAM"

A time to look back: analysis of morphokinetic characteristics of human embryo development.

2013

Objective To describe the times associated with the morphological changes that occur in the embryo during preimplantation development based on the largest sample size described with time lapse. Design Cohort study. Setting University-affiliated private center. Patient(s) A total of 9,530 embryos from 1,806 intracytoplasmic sperm injection (ICSI) cycles. Intervention(s) None. Main Outcome Measure(s) Using a time-lapse system, embryo images were acquired for at least 68 hours, in some cases reaching 120–130 hours. Embryo cleavage time points up to 8-cell-stage (t2–t8) as well as morulae (tM) and blastocyst formation (tB) were registered in hours after ICSI. Additionally, duration of the cell …

<p>Clinical Evaluation of Everolimus in the Treatment of Neuroendocrine Tumors of the Lung: Patient Selection and Special Considerations. A Sys…

2020

Abstract Neuroendocrine tumors (NETs) of the lung are well-differentiated neuroendocrine neoplasms (NENs) with a heterogeneous clinical behaviour. Unlike gastroenteropancreatic NENs where therapeutic armamentarium clearly increased over the last decade, everolimus represented the only clinical practical innovation for lung NET patients over the last years. Therefore, for lung NETs, a multidisciplinary discussion within a dedicated team remains critical for an adequate decision-making. Although the main regulatory authorities considered the everolimus-related evidence is enough to approve the drug in advanced lung NETs, several clinical features deserve to be discussed. In this review, we sy…

Variazioni di miRNA circolanti in casi di carcinoma mammario sottoposti a regime dietetico con oli addizionati di polifenoli

Dal 2002, quando i primi risultati relativi alla possibile associazione tra espressione di alcuni miRNA e cancro furono pubblicati, numerosi studi hanno evidenziato un intervento diretto dei miRNA nella regolazione di geni e di pathways collegati alla sviluppo tumorale. Recentemente si sta sempre più confermando l’evidenza che cambiamenti epigenetici, alterazioni molecolari e componenti bioattivi della dieta possono genericamente modificare l'espressione genica attraverso la modulazione di specifici miRNA. Scopo principale della ricerca è la valutazione dei livelli di espressione di particolari miRNA circolanti nel sangue periferico sia di donne sane che di pazienti affette da carcinoma mam…

Identification and characterization of the grapevine flagellin receptor vvfls2

2014

International audience

Home and mental ill-health: twenty dimensions

2017

In the context of psychiatric rehabilitation and care, home is often associated with health. In the context of deinstitutionalization, however, home has increasingly become the primary site of psychiatric suffering. Drawing on a two-year ethnographic research project with a drama group for young adult mental healthcare service users living in supported housing facilities, this paper presents twenty dimensions of home through which mental ill-health can be approached as a bodily experienced, and discursively and medically structured form of being in the world. These dimensions are here offered as a framework for further exploration of the social, spatial, temporal, structural and embodied as…

Papel de las calpaínas en la remodelación tisular de la glándula mamaria tras el ciclo embarazo/lactancia

2014

En el presente proyecto de tesis se ha contribuido a elucidar el papel de las calpaínas en la muerte celular programada y la remodelación tisular de la glándula mamaria tras el ciclo embarazo/lactancia. La involución de la glándula mamaria se caracteriza por la muerte celular programada (MCP) del epitelio secretor y por la proliferación e invasión de los adipocitos, con el fin de conseguir el estado glandular pre-gestacional. Estudios previos demuestran que las calpaínas, proteasas calcio-dependientes, están activas a lo largo de esta regresión post-lactancia. Estas enzimas, participan en la escisión de numerosas proteínas ubicadas la mayoría en membranas celulares, al poseer las calpaínas …

Pakalpojumu serviss: mājas lapas stāvokļa uzraudzība un atbildīgo personu brīdināšana par iespējamām un esošām problēmām

2017

Lidzekļa “Pakalpojumu serviss: mājas lapas stāvokļa uzraudzība un atbildīgo personu brīdināšana par iespējamām un esošām problēmām” mērķis ir paatrināt servera un timekļa vietne problēmas identificēšanu un savlaicīgi brīdīnāt atbildīgus personus. Ilgstoši nodarbojoties ar projekta uzturu, izveidotas uz Magento platformas uzkrājam pieredzi un problemu risināšanu kas trauce saita darbibu. Problēmu atklāšana un tas risināšana aizniem pietiekoši daudz laika pat pieredzejušam īzstrādātājam. Kaut ko japarbauda regulāri, bet uz to nepietek laiks, bet ja konkrēta problēma ilgi neuzrādās, tad iespēja iemeslu atrast ātri uz izlabot problēmu mazā laika samazinās. Uzradās idēja automatizēt zinamo probl…

Magneto-structural correlations in discrete $Mn^{II}‐W^V$ cyano‐bridged assemblies with polyimine ligands

2010

We present the magneto-structural correlations for two novel discrete cyano-bridged assemblies based on cationic complexes of manganese(II) with diimine ligands and octacyanotungstate(V) ions. The crystal structure of [Mn II (terpy)(dmf)-(H 2 O) 2 ][Mn II (terpy)(H 2 O)(dmf)(μ-NC)W V (CN) 7 ] 2· 6H 2 O (1) (terpy = 2,2';6',2"-terpyridine, dmf = dimethylformamide) contains dinuclear {Mn II W V } - cyano-bridged anions, while the crystal structure of [Mn II (phen) 3 ] 2 [MnII(phen) 2 (μ-NC) 2 -W V (CN) 6 ] 2 (ClO 4 ) 2 ·9H 2 O (2) (phen = 1,10-phenanthroline) is built of tetranuclear {Mn II 2 W V 2} 2- square anions. Intramolecular Mn-W magnetic interactions through the cyano bridges are repr…

Sense and Antisense DMPK RNA Foci Accumulate in DM1 Tissues during Development.

2015

International audience; Myotonic dystrophy type 1 (DM1) is caused by an unstable expanded CTG repeat located within the DMPK gene 3'UTR. The nature, severity and age at onset of DM1 symptoms are very variable in patients. Different forms of the disease are described, among which the congenital form (CDM) is the most severe. Molecular mechanisms of DM1 are well characterized for the adult form and involve accumulation of mutant DMPK RNA forming foci in the nucleus. These RNA foci sequester proteins from the MBNL family and deregulate CELF proteins. These proteins are involved in many cellular mechanisms such as alternative splicing, transcriptional, translational and post-translational regul…

Cells of extramammary Paget's disease express cytokeratins different from those of epidermal cells.

1985

The patterns of expression of cytokeratin polypeptides which are closely correlated to routes of differentiation of epithelial cells were studied in extramammary Paget's disease. Cytokeratins of uninvolved and involved epidermis were analyzed by two-dimensional gel electrophoresis of microdissected tissue preparations as well as by immunofluorescence microscopy using cytokeratin antibodies with different specificities. In uninvolved epidermis, cytokeratins Nos. 1, 5, 6, 10, 11, 14, and 16, characteristic of keratinocytes, were found. Epidermis infiltrated by Paget's cells contained the same components and, in addition, cytokeratins Nos. 7, 8, 18, and 19, the latter being characteristic of s…