Search results for "MASER"

First M87 Event Horizon Telescope Results. II. Array and Instrumentation

2019

The Event Horizon Telescope (EHT) is a very long baseline interferometry (VLBI) array that comprises millimeter- and submillimeter-wavelength telescopes separated by distances comparable to the diameter of the Earth. At a nominal operating wavelength of ~1.3 mm, EHT angular resolution (λ/D) is ~25 μas, which is sufficient to resolve nearby supermassive black hole candidates on spatial and temporal scales that correspond to their event horizons. With this capability, the EHT scientific goals are to probe general relativistic effects in the strong-field regime and to study accretion and relativistic jet formation near the black hole boundary. In this Letter we describe the system design of th…

Pimasertib (PIM) versus dacarbazine (DTIC) in patients (pts) with cutaneous NRAS melanoma: a controlled, open-label phase II trial with crossover

2016

Observation of Poincaré-Andronov-Hopf Bifurcation in Cyclotron Maser Emission from a Magnetic Plasma Trap.

2018

We report the first experimental evidence of a controlled transition from the generation of periodic bursts of electromagnetic radiation into the continuous-wave regime of a cyclotron maser formed in magnetically confined nonequilibrium plasma. The kinetic cyclotron instability of the extraordinary wave of weakly inhomogeneous magnetized plasma is driven by the anisotropic electron population resulting from electron cyclotron plasma heating in a MHD-stable minimum-$B$ open magnetic trap.

Pimasertib Versus Dacarbazine in Patients With Unresectable NRAS-Mutated Cutaneous Melanoma: Phase II, Randomized, Controlled Trial with Crossover

2020

This study investigated the efficacy and safety of pimasertib (MEK1/MEK2 inhibitor) versus dacarbazine (DTIC) in patients with untreated NRAS-mutated melanoma. Phase II, multicenter, open-label trial. Patients with unresectable, stage IIIc/IVM1 NRAS-mutated cutaneous melanoma were randomized 2:1 to pimasertib (60 mg

Generation of multiphoton Fock states by bichromatic adiabatic passage: Topological analysis

2004

We propose a robust scheme to generate multi-photon Fock states in an atom-maser-cavity system using adiabatic passage techniques and topological properties of the dressed eigenenergy surfaces. The mechanism is an exchange of photons from the maser field into the initially empty cavity by bichromatic adiabatic passage. The number of exchanged photons depends on the design of the adiabatic dynamics through and around the conical intersections of dressed eigenenergy surfaces.

Observation of Poincaré-Andronov-Hopf Bifurcation in Cyclotron Maser Emission from a Magnetic Plasma Trap

2018

We report the first experimental evidence of a controlled transition from the generation of periodic bursts of electromagnetic radiation into the continuous-wave regime of a cyclotron maser formed in magnetically confined nonequilibrium plasma. The kinetic cyclotron instability of the extraordinary wave of weakly inhomogeneous magnetized plasma is driven by the anisotropic electron population resulting from electron cyclotron plasma heating in a MHD-stable minimum-B open magnetic trap. peerReviewed

Phase I study of FOLFIRI plus pimasertib as second-line treatment for KRAS-mutated metastatic colorectal cancer

2015

BACKGROUND: The mitogen-activated protein kinase (MAPK) pathway has been implicated in the molecular pathogenesis of human cancers, including metastatic colorectal cancer (mCRC). This provides a rationale for the development of MAPK-targeted agents such as pimasertib. METHODS: Patients with KRAS mutant mCRC were treated in the second-line setting with FOLFIRI (5-fluorouracil/folinic acid/irinotecan) plus pimasertib. The primary objective of the safety run-in phase was to determine the maximum-tolerated dose (MTD) and the recommended phase II dose of pimasertib combined with FOLFIRI. RESULTS: Sixteen patients were enrolled in the trial. Ten and six patients were treated daily with 45 and 60 …

A binary genetic approach to characterize TRPM5 cells in mice

2015

International audience; Transient receptor potential channel subfamily M member 5 (TRPM5) is an important downstream signaling component in a subset of taste receptor cells making it a potential target for taste modulation. Interestingly, TRPM5 has been detected in extra-oral tissues; however, the function of extra-gustatory TRPM5-expressing cells is less well understood. To facilitate visualization and manipulation of TRPM5-expressing cells in mice, we generated a Cre knock-in TRPM5 allele by homologous recombination. We then used the novel TRPM5-IRES-Cre mouse strain to report TRPM5 expression by activating a tau GFP transgene. To confirm faithful coexpression of tau GFP and TRPM5 we gene…

Water Maser Motions in W3(OH) and a Determination of Its Distance

2006

We report phase-referencing VLBA observations of H2O masers near the star-forming region W3(OH) to measure their parallax and absolute proper motions. The measured annual parallax is 0.489 +/- 0.017 milli-arcseconds (2.04 +/- 0.07 kpc), where the error is dominated by a systematic atmospheric contribution. This distance is consistent with photometric distances from previous observations and with the distance determined from CH3OH maser astrometry presented in a related paper. We also find that the source driving the H2O outflow, the ``TW-object'', moves with a 3-dimensional velocity of > 7 km/s relative to the ultracompact HII region W3(OH).

Control of electron-cyclotron instability driven by strong ECRH in open magnetic trap

2018

We discuss the laboratory experiment on a controlled transition from the generation of periodic bursts of electromagnetic radiation into the continuous-wave regime of a cyclotron maser formed in a magnetically confined non-equilibrium plasma (Shalashov A. G. et al. , Phys. Rev. Lett. , 114 (2018) 205001). The kinetic cyclotron instability of the extraordinary wave of a weakly inhomogeneous magnetized plasma is driven by the anisotropic electron population resulting from electron cyclotron plasma heating in a MHD-stable minimum-B open magnetic trap. In the present communication we focus on a theoretical model that explains the existing data and motivates further experiments.