Search results for "MAb"
showing 10 items of 1716 documents
Basic Concepts of Power Distribution Network Design for High-Speed Transmission
2011
This paper tries to gather the Power Distribution Network (PDN) techniques used to preserve power integrity in PCB designs when transmitting data rates over 6 Gbps using the newest commercial optical modules. The PDN design described allows for proper impedance control of the power supply with the appropriate choice of the number, location and values of capacitors. This method needs the knowledge of the electrical RLC model of the regulators, copper planes, capacitors and vias used in the PCB. A particular case of PDN design will be presented for a module using one SNAP12 optical transmitter and one receiver connected to an Altera Stratix II GX FPGA. This board is designed to work with data…
Preemptive Transfer of GMP-Grade CD8-Depleted Donor Lymphocytes after T-Cell Depleted Reduced-Intensity Transplantation.
2005
Abstract The combination of fludarabin (150mg/m2) / melphalan (140mg/m2) based reduced-intensity allo-transplantation (RIT) with in vivo T-cell depletion (TCD) by the anti-CD52 antibody alemtuzumab (100mg) has demonstrated efficient engraftment and reduced graft-versus-host disease (GVHD) (Kottaridis et al., Blood 2000). However, the slow lymphocyte recovery following this protocol is associated with reduced anti-infectious and antitumor immunity. In an attempt to improve immune-reconstitution after TCD / RIT, we investigated the early preemptive use of CD8-depleted donor lymphocyte infusions (DLIs). For CD8 depletion of donor leukaphereses, a new depletion protocol using clinical grade CD8…
Response to Anti CD20 Monoclonal Antibody Rituximab® and Epitope Mapping of Inhibitory Antibodies in Patients with Acquired Haemophilia.
2006
Abstract Introduction: Acquired haemophilia (AcH) is associated with the development of polyclonal autoantibodies against FVIII, which affect directly the A2 or C2 domain of the FVIII molecule. Immunomodulatory therapy regimes to normalize FVIII levels and to eliminate the inhibitor are essential options in the treatment of patients (pts) with AcH. The aims of the present study were to investigate the response to Rituximab® and to localize the inhibitor epitopes on the FVIII domains. Patients and Methods: In 5 pts with AcH (2 females,3 males; age: 64–81 yrs) the inhibitor titers ranged from 9 to 156 BU and the FVIII activities from <1 % to 6 %. Rituximab® was administered once weekly…
Impact of DLI after In Vivo T-Cell-Depletion: Prophylactic CD8 Depleted or Preemptive CD3pos DLI?
2016
Abstract Introduction: The combination of reduced-intensity conditioning (RIC) with in vivo T-cell depletion by alemtuzumab prior to hematopoietic stem cell transplantation (HSCT) has demonstrated efficient engraftment and reduced graft-versus-host disease (GVHD). However, this regimen is associated with slow lymphocyte recovery leading to a delayed anti-infectious and anti-malignant immunity. DLI can be used to improve immune reconstitution. Here we investigate on the impact of different DLI: prophylactic CD8-depleted DLI vs preemptive non-depleted DLI. Methods: 256 patients with different hematologic malignancies were planned for treatment with DLI after allogeneic HSCT following reduced …
Anti-resorptive treatment in osteoporosis and their deleterious effects on maxillary bone metabolism in clinical dentistry
2017
Bisphosphonates (BPs) and other antiresorptive agents such as denosumab are widely prescribed for the treatment of osteoporosis and are also used in patients with multiple myeloma and metastatic breast or prostate cancer for avoiding bone reabsorption and fractures that result in increased morbidity–mortality among such individuals. Osteonecrosis of the jaws is an important complication of exposure to BPs or other antiresorptive agents, and although its prevalence is low, it can pose management problems. The definition, diagnosis, and classification of osteonecrosis have evolved since Marx reported the first cases in 2003. The present chapter offers a review and update on the existing diagn…
Abciximab Facilitates the Rate and Extent of Thrombolysis
1999
Background —The TIMI 14 trial tested the hypothesis that abciximab, the Fab fragment of a monoclonal antibody directed to the platelet glycoprotein (GP) IIb/IIIa receptor, is a potent and safe addition to reduced-dose thrombolytic regimens for ST-segment elevation MI. Methods and Results —Patients (n=888) with ST-elevation MI presenting <12 hours from onset of symptoms were treated with aspirin and randomized initially to either 100 mg of accelerated-dose alteplase (control) or abciximab (bolus 0.25 mg/kg and 12-hour infusion of 0.125 μg · kg −1 · min −1 ) alone or in combination with reduced doses of alteplase (20 to 65 mg) or streptokinase (500 000 U to 1.5 MU). Control patients recei…
A new ATLAS muon CSC readout system with system on chip technology on ATCA platform
2015
The ATLAS muon Cathode Strip Chamber (CSC) backend readout system has been upgraded during the LHC 2013-2015 shutdown to be able to handle the higher Level-1 trigger rate of 100 kHz and the higher occupancy at Run 2 luminosity. The readout design is based on the Reconfigurable Cluster Element (RCE) concept for high bandwidth generic DAQ implemented on the Advanced Telecommunication Computing Architecture (ATCA) platform. The RCE design is based on the new System on Chip XILINX ZYNQ series with a processor-centric architecture with ARM processor embedded in FPGA fabric and high speed I/O resources together with auxiliary memories to form a versatile DAQ building block that can host applicati…
Performances of the Fault Decoupling Device when unbalanced and multiple faults occur on distribution systems.
2005
Nowadays industrial processes are largely based on electronic devices such as programmable logic controllers and adjustable speed drives. Consequently, industrial equipments became less tolerant towards power supply disturbances. Voltage dips due to faults are surely among the worst disturbances for industrial equipments. A paper machine can be affected by disturbances of only 10% voltage drop lasting for 100 ms. A voltage dip of 75% (of the nominal voltage) with a duration shorter than 100 ms results in material loss in the range of thousands of US Dollars for semiconductors industry [1].
A hardware skin-segmentation IP for vision based smart ADAS through an FPGA prototyping
2017
International audience; In this paper we presents a platform based design approach for fast HW/SW embedded smart Advanced Driver Assistant System (ADAS) design and prototyping. Then, we share our experience in designing and prototyping a HW/SW vision based smart embedded system as an ADAS that helps to increase the safety of car's drivers. We present a physical prototype of the vision ADAS based on a Zynq FPGA. The system detects the fatigue state of the driver by monitoring the eyes closure and generates a real-time alert. A new HW/SW codesign skin segmentation step to locate the eyes/face is proposed. Our presented new approach migrates the skin segmentation step from processing system (S…
Cetuximab +/- chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-sp…
2012
Cetuximab is a human/mouse chimeric IgG1 monoclonal antibody (mAb) to epidermal growth factor receptor, approved for colorectal carcinoma treatment in combination with chemotherapy. The immune-mediated effects elicited by its human fraction of crystallization moiety might critically contribute to the overall anti-tumor effectiveness of the antibody. We therefore investigated cetuximab ability to promote colon cancer cell opsonization and phagocytosis by human dendritic cells (DCs) that are subsequently engaged in antigen-cross presentation to cytotoxic T-lymphocyte (CTL) precursors. Human colon cancer cell lines were evaluated for susceptibility to DC-mediated phagocytosis before and after …