Search results for "MAb"

Applicazione della tecnologia MABR per l’incremento della capacità depurativa di impianti esistenti

2019

La necessità di adeguare e/o ampliare gli esistenti impianti biologici di trattamento delle acque reflue, sia urbane che industriali, sia per potenziarne la capacità depurativa che per ottemperare al rispetto di limiti allo scarico per gli effluenti trattati sempre più restrittivi, si scontra sempre più di frequente con la difficoltà a reperire adeguate aree di espansione degli impianti. Pertanto, negli ultimi decenni sono state proposte nuove tecnologie atte a ridurre al massimo il volume dei reattori biologici, o incrementando la concentrazione di biomassa presente nel sistema e la capacità dello stadio finale del trattamento biologico, ossia quello di separazione solido-liquido, come nel…

Sicurezza dell’Infliximab in bambini con malattia infiammatoria cronica intestinale (IBD): Registro pediatrico italiano di terapia biologica per le I…

2008

Elementu identifikācijas metožu salīdzinājums farmaceitiskajos paraugos

2019

Elementu identifikācijas metožu salīdzinājums farmaceitiskajos paraugos. Sleže V., zinātniskais vadītājs Mg. Chem. Bērtiņš M. Bakalaura darbs, 43 lappuses, 15 attēli, 12 tabulas, 31 literatūras avoti. Latviešu valodā. Organisko vielu sintēzēs tai starpā farmaceitisko preparātu ražošanā nereti tiek izmantoti katalizatori, lai ražošanas process notiktu ātrāk. Katalizatoru atliekas galaproduktā nav vēlamas, it īpaši farmaceitiskajos preparātos, kuri tiek lietoti cilvēku uzturā. Ir noteiktas direktīvas, kuras ierobežo katalizatoru maksimālās devas farmaceitiskajos preparātos. Tāpēc ir sastādītas ķīmiski analītiskās metodes, kuras spēj noteikt, cik daudz ir palikuši katalizatoru atlikumi.

Makro- un mikroelementu satura variācijas melnā plūškoka (Sambucus nigra) ogās un ziedos

2021

Pētījuma ietvaros tika analizēts melnā plūškoka (Sambucus nigra) makro- un mikroelementu saturs ogās un ziedos. Ogu paraugu sagatavošanai izmantoja sauso mineralizāciju. Fe, Mn un Zn saturs tika noteikts izmantojot FAAS; K saturs ar FAES; citu metālisko un nemetālisko elementu noteikšana ar ICP-MS metodi. Ziedkopu paraugu sagatavošanai izmantoja slapjo mineralizāciju ar mikroviļņu enerģiju. Ķīmisko analīzi veica ar ICP-MS. Iegūtie elementu rezultāti tika atbilstoši apstrādāti, salīdzināti ar dažādiem literatūras avotiem un pētījumiem, kā arī izvērtēts to nozīmīgums dzīvajos organismos.

Experimental and numerical analysis on post welding formability of FSWed AZ31 magnesium alloy thin joints obtained using a "Pinless" tool configurati…

2012

The post welding formability of friction stir welded AZ31 magnesium alloy thin sheets (1.5 mm thick), obtained using a “pinless” tool configuration, was widely investigated by means of the hemispherical punch method at 350°C, with a constant crosshead speed of 0.1 mm/s. The results were compared with those obtained on the base material. It has shown that formability of the joints is lower than the one of the base material. The experimental work was supported by a numerical investigation based on FEM in order to highlight the material flow occurring during the welding process. Additionally, hemispherical punch tests were simulated starting from the calculated conditions, in terms of accumula…

THE USE OF INTERLEUKIN 1 RECEPTOR ANTAGONIST (ANAKINRA) IN KAWASAKI DISEASE: A RETROSPECTIVE CASES SERIES

2018

Introduction: Persistent fever and inflammation after infusion of 2g/kg of IVIG, the standard treatment of KD represents a high-risk situation for coronary aneurysms in Kawasaki disease. Identifying patients at risk for IVIG resistance is difficult outside the Asian population, and there remains a critical unmet need to identify an anti-inflammatory treatment that is efficacious in all KD patients. Recent evidence from studies in animals and humans suggest a critical role for interleukin-1 (IL-1) α and β in the pathogenesis of KD. Objectives: To identify the clinical characteristics, reasons for use and response to treatment with anakinra in a retrospective series of patients with Kawasaki …

EORTC-1203-GITCG - the “INNOVATION”-trial: Effect of chemotherapy alone versus chemotherapy plus trastuzumab, versus chemotherapy plus trastuzumab pl…

2019

10–20% of patients with gastric cancer (GC) have HER2+ tumors. Addition of trastuzumab (T) to cisplatin/fluoropyrimidine-based chemotherapy (CT) improved survival in metastatic, HER2+ GC. When pertuzumab (P) was added to neoadjuvant T and CT, a significant increase in histopathological complete response rate was observed in HER2+ breast cancer. This study aims to investigate the added benefit of using both HER2 targeting drugs (T alone or the combination of T + P), in combination with perioperative CT for localized HER2+ GC. This is a prospective, randomized, open-label, phase II trial. HER2 status from patients with resectable GC (UICC TNM7 tumor stage Ib-III) will be centrally determined.…

The STAT3 Inhibitor Galiellalactone Reduces IL6-Mediated AR Activity in Benign and Malignant Prostate Models

2018

IL6/STAT3 signaling is associated with endocrine therapy resistance in prostate cancer, but therapies targeting this pathway in prostate cancer were unsuccessful in clinical trials so far. The mechanistic explanation for this phenomenon is currently unclear; however, IL6 has pleiotropic effects on a number of signaling pathways, including the androgen receptor (AR). Therefore, we investigated IL6-mediated AR activation in prostate cancer cell lines and ex vivo primary prostate tissue cultures in order to gain a better understanding on how to inhibit this process for future clinical trials. IL6 significantly increased androgen-dependent AR activity in LNCaP cells but importantly did not infl…

Exome Analysis Reveals Genomic Markers Associated with Better Efficacy of Nivolumab in Lung Cancer Patients

2019

Abstract Purpose: Immune checkpoint inhibitors revolutionized the treatment of non-small cell lung cancer (NSCLC). However, only one-quarter of patients benefit from these new therapies. PD-L1 assessment and tumor mutational burden (TMB) are available tools to optimize use of checkpoint inhibitors but novel tools are needed. Exome sequencing could generate many variables but their role in identifying predictors of response is unknown. Experimental Design: We performed somatic and constitutional exome analyses for 77 patients with NSCLC treated with nivolumab. We studied: one-tumor-related characteristics: aneuploidy, CNA clonality, mutational signatures, TMB, mutations in WNT, AKT, MAPK, an…

Predictive factors of severe early treatment-related toxicity in patients receiving first-line treatment for metastatic colorectal cancer: Pooled ana…

2021

Few studies have explored the association between baseline characteristics and the occurrence of early toxicities in patients treated with first-line chemotherapy for metastatic colorectal cancer (mCRC).Individual patient data of 2190 patients enrolled in 10 prospective FFCD (Fédération Francophone de Cancérologie Digestive) trials were analysed. Severe early toxicity was defined as the occurrence of grade ≥III toxicity within 3 months after initiation of chemotherapy (ET3).Patients received monotherapy based on 5-FU (n = 1068), a cytotoxic doublet (n = 395) or tritherapy with a cytotoxic doublet plus anti-VEGF agent or a cytotoxic triplet (n = 727). The patients received 5-FU (100%), Irino…