Search results for "MC"
showing 10 items of 2122 documents
PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation
2020
Significance The photoreceptor outer segments are primary cilia, modified for phototransduction by incorporation of stacked opsin-loaded membrane disks that are continuously regenerated. This process is disrupted in several types of inherited retinal dystrophy, but the driving force remained unclear. We show that C2orf71/PCARE (photoreceptor cilium actin regulator), associated with inherited retinal dystrophy subtype RP54, efficiently recruits the Arp2/3 complex activator WASF3 to the cilium. This activates an actin dynamics-driven expansion of the ciliary tip, resembling membrane evagination in lamellipodia formation. Colocalization of this actin dynamics module to the base of the outer se…
Le changement climatique : où en sommes-nous ?
2018
Greenhouse gases (GHGs), naturally part of the atmosphere, have protected us from severe glaciations in the past. Today, human activities increase GHG concentrations and cause rapid and unprecedented Earth warming. Climate change is not resume only to warming, water cycle is also changed. All the research confirms: the climate is changing fast, too fast for ecosystems and societies to adapt. Despite the alerts of the international scientific community, States gathered into Conferences of the Parties (COP) ratify agreements but do not comply with all their commitments. Public opinion polls indicate that climate change is perceived as a risk, but jobs and taxes override environmental concerns…
Modèle des voies réflexes et cérébelleuses, permettant le calcul de fonctions inverses et la commande d'un segment mécanique mobile
2004
14/07/2004; La commande et le contrôle des mouvements des membres par les voies cérébelleuses et réflexes sont modélisées au moyen d'un circuit dont la structure est déduite de contraintes fonctionnelles. 1/ La première contrainte est que les mouvements rapides des membres doivent être précis, quoiqu'ils ne puissent pas être commandés en boucle fermée au moyen de signaux sensoriels. Les voies qui préparent les ordres moteurs doivent donc contenir des fonctions inverses approximées des fonctions biomécaniques du membre et des muscles. Or une telle fonction peut être calculée au moyen de boucles de rétroaction parallèles, dont la structure est comparable à l'anatomie des voies cérébelleuses. …
LA STATISTICA PER LA MISURA DELLA BELLEZZA
2018
Abstract · Statistics to measure beauty · We would like to point out an experimentation performed in an italian school in the first year of a Professional School in Palermo (Fashion course).A lot of ideas, such as beauty, proportionality, perfection can be found in many professional subjects and also in basic ones (Maths, Italian language, English language, Sciences, etc.). We tried to adapt M@t.abel (E-learning basic Maths) materials and methods “L’uomo di Vitruvio” (Bartolomei et al., 2010), to a professional school. This didactic activity, organized by the Maths teacher, involved other three teachers and lasted for 50 hours, not taking into account the planning and presentation to the cl…
The new version of the pictorial scale of Perceived Movement Skill Competence in Spanish children: Evidence of validity and reliability. [La nueva ve…
2019
The purpose of this study was to i) examine reliability and construct validity of the pictorial scale of Perceived Movement Skill Competence (PMSC) aligned to the third version of the Test of Gross Motor Development (TGMD-3) in a sample of Spanish children; and to ii) analyse the validity of the PMSC and children’s perceived motor competence (MC) according to gender. A convenience sample of 361 children (55.7% boys) between 4 and 11 years-old participated. The pictorial scale of PMSC (19 items) was administered (a random subsample repeated the PMSC twice). Test-retest reliability using Intraclass Correlation Coefficients and construct validity using a Bayesian Structural Equation Modeling a…
Regionalisme i drets humans
2012
Conferència sobre regionalisme i drets humans donada en el congrés de lleis regionals e internacionals realitzat en València del 13 al 15 de Septembre.
Safety of Dietary Guanidinoacetic Acid: A Villain of a Good Guy?
2021
Guanidinoacetic acid (GAA) is a natural amino acid derivative that is well-recognized for its central role in the biosynthesis of creatine, an essential compound involved in cellular energy metabolism. GAA (also known as glycocyamine or betacyamine) has been investigated as an energy-boosting dietary supplement in humans for more than 70 years. GAA is suggested to effectively increase low levels of tissue creatine and improve clinical features of cardiometabolic and neurological diseases, with GAA often outcompeting traditional bioenergetics agents in maintaining ATP status during stress. This perhaps happens due to a favorable delivery of GAA through specific membrane transporters (such as…
¿Cómo impulsa la Comunicación Integrada de Marketing la satisfacción del huésped?: una propuesta a través del conocimiento ecológico y la co-creación…
2022
[ES] La creciente necesidad de aumentar la eficacia de las estrategias de comunicación en el sector hotelero impulsa la investigación acerca de cómo es posible intensificar sus efectos. De entre las distintas alternativas, el enfoque CIM basado en la sostenibilidad empieza a adquirir cada vez más importancia. El presente trabajo tiene como objetivo examinar las relaciones entre la CIM para la sostenibilidad, el conocimiento ecológico, la co-creación de valor y la satisfacción. Sobre la base de los efectos en cadena que se investigan, se propone un modelo teórico, que se contrasta a partir de un estudio empírico con una muestra de 303 huéspedes, en hoteles de Kyiv (Ucrania). Los resultados r…
Les terres cuites architecturales comme sources d'information chronologique et technique des édifices avant l'an mil
2008
A partir de l'étude d'un édifice phare de l'Ouest de la France (Église Notre-Dame sous Terre au Mont-Saint-Michel) mous montrons comment le couplage des études de bâti permettant l'identification d'ensembles maçonnés et leur chronologie relative, avec les méthodes de datation des terres cuites par thermoluminescence et archéomagnétisme, et des charbons de mortier par radiocarbone, aboutit à des informations particulièrement novatrices sur la chronologie de la production des briques, leur éventuel remploi ou sur leur production ad nove, mais aussi, plus inattendu, sur des éléments technologiques de leur production. Les orientations actuelles des recherches méthodologiques pour la datation ph…
Incorporation of Pt(II) complex with [amino-2(methylthio)(1,2,4)triazole-(1,5-a)pyrimidine-6-carboxylic-acid] ligand in MCM41 for controlled release
2015
Drug carriers play a critical role for the loading and the release of the drug. A promising frontier is represented by a new class of innovative medicines that represents directional transport vehicles "drug delivery" and consist of assembled structures carrier (nano)-drug. Silica-based materials, nontoxic, biocompatible, have been used as adjuvant and excipient in pharmaceutical technology. In this class of compounds, the mesoporous materials, such as MCM41, SBA-15 and hexagonal mesoporous silica, have been investigated for medication and drug delivery due to their properties. In fact, these materials show a large specific pore volume made up of regular pores having a diameter in the nanom…