Search results for "MCF7"
showing 3 items of 3 documents
Halloysite nanotubes as a carrier of cornelian cherry (Cornus mas L.) bioactives
2020
Abstract Cornelian cherry fruit extract rich in anthocyanins and iridoids was encapsulated in the halloysite nanotubes in order to obtain a stable nanoscale system for better delivery and prolonged release of bioactive constituents. The cyclic vacuum technique was used for halloysite nanotubes-cornelian cherry composite preparation and the loading of 8.5 wt% was achieved. Pure cornelian cherry extract exhibited antiproliferative effect on HT-29, MCF7, and MRC-5 cells, pristine halloysite nanotubes affected the growth of MCF7 cells, while halloysite nanotubes-cornelian cherry composites demonstrated proliferative activity in all tested cells. The sustained release of anthocyanins was achieve…
New Synthetic Nitro-Pyrrolomycins as Promising Antibacterial and Anticancer Agents
2020
: Pyrrolomycins (PMs) are polyhalogenated antibiotics known as powerful biologically active compounds, yet featuring high cytotoxicity. The present study reports the antibacterial and antitumoral properties of new chemically synthesized PMs, where the three positions of the pyrrolic nucleus were replaced by nitro groups, aiming to reduce their cytotoxicity while maintaining or even enhancing the biological activity. Indeed, the presence of the nitro substituent in diverse positions of the pyrrole determined an improvement of the minimal bactericidal concentration (MBC) against Gram-positive (i.e., Staphylococcus aureus) or -negative (i.e., Pseudomonas aeruginosa) pathogen strains as compare…
Identification of mechanism(s) leading to hyperdiploidy in progenitor tumor cells derived from MCF7 breast cancer cells
2010
Stem cells are a minor population of mostly resting cells defined by their long life, high clonogenicity, self-replicating potential, plasticity, and drug resistance (Finn, 2008). Cells with these properties have been identified in various normal and cancerous human tissues (Wicha, 2006), as well as in several long-term tumor cell lines (Setoguchi, 2004). We have some preliminary data indicating that cells isolated from MCF7 line divide slowly and form spheres, both features of progenitors tumor cells, when grown in ultralow adherent plates and in absence of serum. Furthermore, these features were associated to two distinct populations characterized by different content in terms of number o…