Search results for "MCP"

showing 10 items of 42 documents

SARS CoV2 infection _The longevity study perspectives

2021

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MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews
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Toxicity of 5- chloro- 3- methyl- catechol to rat: Chemical observations and light microscopy of the tissue

1979

5-chloro-3-methyl-catechol was first time described by GAUNT and EVANS (1961) as a metabolite of MCPA (4-chloro-2-methylphenoxyacetic aci~which is the most widely used herbicide in the Nordic countries. The toxicity of the metabolite 5-chloro-3-methylcatechol bas hot been studied so far. Other catechols like 3,5dichlorocatechol has been shown to be a metabollte of 2,4-D (BOLLAG et ai. 1968a, BOLLAG et ai. 1968b), and it has been proven to be toxic to cells by HORVATH (1971). The catechols are metabolized by bacteria finally to muconic semialdehyde (HORVATH 1970, HORVATH and ALEXANDER 1970). In this work the toxicity of 5-chloro-3-methyl-catechol to maie rats was studied in acute and subchro…

MaleMicroscopyCatecholMethyl CatecholbiologyHealth Toxicology and MutagenesisMetaboliteCatecholsGeneral MedicineToxicologybiology.organism_classificationPollutionMCPAQuantitative determinationRatsLethal Dose 50Residue (chemistry)chemistry.chemical_compoundchemistryBiochemistryToxicityAnimalsBacteriaBulletin of Environmental Contamination and Toxicology
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CD40 ligand and MCP-1 as predictors of cardiovascular events in diabetic patients with stroke.

2009

Aim: Up-regulation of soluble CD40 ligand (sCD40L) and of monocyte chemoattractant protein-1 (MCP-1) has been found in diabetes and in patients with acute cerebral ischemia. We asked whether (i) the two molecules are similarly upregulated among non-lacunar and lacunar diabetic strokes and (ii) sCD40L and/or MCP-1 predict the risk of cardiovascular events in this setting.Methods: Ninety patients with type 2 diabetes mellitus presenting with an acute ischemic stroke (compared with 45 control subjects) were evaluated on admission and up to 36 months (median 24 months) after the event.Results: Diabetic patients with acute stroke had higher plasma CD40L and MCP-1 than controls (p<0.0001), wit…

MaleRiskCD40 ligand stroke diabetesmedicine.medical_specialtystrokeCD40L MCP-1Settore MED/09 - Medicina Internacerebral ischemia; chemokines; cytokines; diabetes mellitusCD40 LigandIschemiachemokinesDiseasecerebral ischemiaCohort StudiesDiabetes ComplicationsInternal medicineDiabetes mellitusInternal MedicineDiabetes MellitusMedicineCD40LHumanscardiovascular diseasesStrokeChemokine CCL2Ageddiabetesbusiness.industryProportional hazards modelBiochemistry (medical)Type 2 Diabetes MellitusMiddle Agedmedicine.diseasecytokinesSurgeryStrokeTreatment OutcomeQuartileGene Expression RegulationCardiologyRegression AnalysisFemaleCardiology and Cardiovascular MedicinebusinessCohort studyMCP-1
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The mutagenicity of MCPA and its soil metabolites, chlorinated phenols, catechols and some widely used slimicides in Finland

1977

MaleSalmonella typhimuriumChemistryHealth Toxicology and MutagenesisCatecholsGeneral Medicine2-Methyl-4-chlorophenoxyacetic AcidIn Vitro TechniquesToxicologyPollutionMCPAGlycolatesRatschemistry.chemical_compoundLiverChlorinated phenolsEnvironmental chemistryAnimalsEcotoxicologyOrganic chemistryPesticidesChlorophenolsMutagensBulletin of Environmental Contamination and Toxicology
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Acute and subchronic toxicity of 2-methyl-4-chlorophenoxyacetic acid (MCPA) in male rat. I. Light microscopy and tissue concentrations of MCPA.

1977

MaleTissue concentrationsChromatography GasTime FactorsHealth Toxicology and MutagenesisDrinking2-Methyl-4-chlorophenoxyacetic AcidToxicologyMCPAToxicologyLethal Dose 50chemistry.chemical_compoundEcotoxicologyAnimalsChromatography2-Methyl-4-chlorophenoxyacetic AcidBody WeightGeneral MedicinePollutionSubchronic toxicityGlycolatesRatschemistryLiverOrgan SpecificitySpleenBulletin of environmental contamination and toxicology
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Robert E. Lee in Love and War written by John Jakes : comparison with accounts by historians Foote, Catton and McPherson

2005

McPherson James MLove and warFoote ShelbyAmerican Civil WarJakes JohnLee Robert EPohjois-Amerikan sisällissotaAmerican historyCatton Brucenew historicismcomparative study
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Magnetic molecularly imprinted polymer for the simultaneous selective extraction of phenoxy acid herbicides from environmental water samples

2022

[EN] A selective magnetic molecularly imprinted polymer (MMIP) was synthetized with 4-chloro-2-methylphenoxyacetic acid as template and 4-vinylpiridine as monomer in presence of vinylized magnetite nanoparticles. Scanning electron microscopy, nitrogen adsorption-desorption isotherms, Fourier transform infrared spectrometry and vibrating sample magnetometry were applied to characterize the resulting material. The synthesized MMIP was applied as sorbent in magnetic molecularly imprinted solid-phase extraction (MMISPE) for selective extraction of a mixture of the five herbicides 4-chloro-2-methylphenoxyacetic acid (MCPA), 4-(4-chloro-2-methylphenoxy)butyric acid (MCPB), mecoprop (MCPP), fenoxa…

MecopropHerbicidas fenoxiácidosSorbentPolymersNanopartículas magnéticasMCPAHigh-performance liquid chromatographyAnalytical ChemistryMolecular Imprintingchemistry.chemical_compoundMolecularly Imprinted PolymersQUIMICA ANALITICAExtracción en fase sólidaPolimeros de impronta molecularMuestras de aguaChromatographyHerbicidesChemistryMagnetic PhenomenaSolid Phase ExtractionExtraction (chemistry)Molecularly imprinted polymerWaterMIPMonomerMagnetic nanoparticlesAdsorptionHPLCTalanta
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Primary Microcephaly with Novel Variant of MCPH1 Gene in Twins: Both Manifesting in Childhood at the Same Time with Hashimoto's Thyroiditis

2020

AbstractThis study is a clinical report on twin females affected by primary microcephaly who displayed at molecular analysis of heterozygous novel MCPH1 variant. The twins at the age of 10 years developed, in coincidental time, a diagnosis of autoimmune juvenile thyroiditis. The main clinical features presented by the twins consisted of primary microcephaly with occipitofrontal circumference measuring −2 or −3 standard deviation, facial dysmorphism, typical nonsyndromic microcephaly, and mild intellectual disability. Molecular analysis of the major genes involved in primary microcephaly was performed and the following result was found in the twins: MCPH1; chr8.6357416; c.2180 C > T (rs 1…

MicrocephalyPediatricsmedicine.medical_specialtyThyroiditisPathogenesis03 medical and health sciences0302 clinical medicineHashimoto's thyroiditisThyroid peroxidaseIntellectual disabilitymedicineGenetic predispositionMissense mutationGenetics (clinical)0303 health sciencesbiologybusiness.industryprimary microcephaly030305 genetics & hereditytwinsmedicine.diseaseThyroid disorderautoimmune juvenile thyroiditisPediatrics Perinatology and Child Healthbiology.proteinbusinessMCPH1 variants030217 neurology & neurosurgeryJournal of Pediatric Genetics
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Neutron–gamma mixed field measurements by means of MCP–TLD600 dosimeter pair

2007

Abstract In this paper, we compared the TL response of three types of thermoluminescence dosimeters, TLD600 (6LiF:Mg,Ti), TLD700 (7LiF:Mg,Ti) and MCP (LiF:Mg,Cu,P) after exposure to a n–γ mixed field in the fluence range of radiotherapeutic applications. Since a dosimeter pair is required to discriminate the two components of the mixed field, we analyzed the ability of each dosimeter pair to provide the fluence value in the mixed field. At this aim we performed a 60Co–γ calibration and a neutron calibration for all three dosimeter types. Finally, a blind test was performed in order to analyze the accuracy of each dosimeter pair and we found that in this mixed field the fluence value obtaine…

Nuclear and High Energy PhysicsDosimeterField (physics)ChemistryThermoluminescenceTLD600TLD700MCPThermal neutronsNeutron dosimetryRadiochemistryAnalytical chemistryFluenceThermoluminescenceNeutron temperatureCalibrationDosimetryNeutronInstrumentationNuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
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New Fast Interaction Trigger for ALICE

2017

The LHC heavy-ion luminosity and collision rate from 2021 onwards will considerably exceed the design parameters of the present ALICE forward trigger detectors and the introduction of the Muon Forward Tracker (MFT) will significantly reduce the space available for the new trigger detectors. To comply with these conditions a new Fast Interaction Trigger (FIT) will be built. FIT will be the main forward trigger, luminometer, and interaction-time detector. It will also determine multiplicity, centrality, and reaction plane of heavy-ion collisions. FIT will consist of two arrays of Cherenkov quartz radiators with MCP-PMT sensors and of a plastic scintillator ring. By increasing the overall acce…

Nuclear and High Energy PhysicsPhysics::Instrumentation and DetectorsFast Interaction TriggerScintillatorALICE upgrade01 natural sciencesPLANACON XP85012Nuclear physics0103 physical sciencesRedundancy (engineering)MCP-PMT010306 general physicsInstrumentationCherenkov radiationCollision ratePhysicsLarge Hadron ColliderMuonta114010308 nuclear & particles physicsbusiness.industryDetectorElectrical engineeringbusinessCentralityHL-LHCdetector R&DNuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
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