Search results for "MCPH"

Optimization of the characteristic angles of both front and rear McPherson suspensions on a circular track using multi-body numerical simulation

2009

The research reported in this paper aims to simulate the road-holding of a virtual vehicle using multi-body simulation to estimate both the contact forces between the tyre and ground and the roll motion when cornering. Furthermore, the effect of the characteristic angles on the variation in the forces of the tyre in contact with the ground is studied to determine optimal values for these angles. Emphasis is placed on an average-class vehicle, of which both the external dimensions and mass are chosen appropriately, with a McPherson suspension mounted on both the front and the rear. The characteristic values of the camber and toe-in angles, in both the front and the rear, are optimized for m…

A novel mutation of WDR62 gene associated with severe phenotype including infantile spasm, microcephaly, and intellectual disability

2017

Abstract The autosomal recessive form of primary microcephaly (MCPH) is a rare disorder characterized by head circumference of at least 3 standard deviation below the mean. The MCPH exhibits genetic heterogeneity with thirteen loci (MCPH1-MCPH13) identified, and associated with variable degree of intellectual disability. It has been reported that WDR62 is the second causative gene of autosomal recessive microcephaly (MCPH2) playing a significant role in spindle formation and the proliferation of neuronal progenitor cells. We report a clinical feature, electroclinical findings, and clinical course of a patient with a severe phenotype of MCPH2 including microcephaly, refractory infantile spas…

Robert E. Lee in Love and War written by John Jakes : comparison with accounts by historians Foote, Catton and McPherson

2005

Primary Microcephaly with Novel Variant of MCPH1 Gene in Twins: Both Manifesting in Childhood at the Same Time with Hashimoto's Thyroiditis

2020

AbstractThis study is a clinical report on twin females affected by primary microcephaly who displayed at molecular analysis of heterozygous novel MCPH1 variant. The twins at the age of 10 years developed, in coincidental time, a diagnosis of autoimmune juvenile thyroiditis. The main clinical features presented by the twins consisted of primary microcephaly with occipitofrontal circumference measuring −2 or −3 standard deviation, facial dysmorphism, typical nonsyndromic microcephaly, and mild intellectual disability. Molecular analysis of the major genes involved in primary microcephaly was performed and the following result was found in the twins: MCPH1; chr8.6357416; c.2180 C > T (rs 1…