Search results for "MDA"
showing 10 items of 275 documents
Carbachol-induced network oscillations in the intact cerebral cortex of the newborn rat.
2003
In mature cortex, activation of the cholinergic system induces oscillatory network activity and facilitates synaptic plasticity. We used an in vitro preparation of the intact cerebral cortex and cortical slices of the neonatal rat to study carbachol (CCh, >or=30 micro M)-induced network oscillations during the early postnatal period. Multi-site extracellular recordings revealed CCh-induced transient beta oscillations with an average duration of 4.6 +/- 0.2 s, amplitude of 123 +/- 7.4 microV and frequency of 17.7 +/- 0.5 Hz. These oscillations propagated uniformly at 0.5-1.5 mm/s over the cortex and were reversibly blocked by tetrodotoxin (TTX) and atropine, indicating that they depended on …
Osservazioni di Cephalota circumdata imperialis (KLUG, 1834) (Insecta Carabidae Cicindelinae) in Sicilia.
2016
Records of Cephalota circumdata imperialis (KLUG, 1834) (Insecta Carabidae Cicindelinae) in Sicily.
Activity-Dependent Regulation of Neuronal Apoptosis in Neonatal Mouse Cerebral Cortex
2007
A massive neuronal loss during early postnatal development has been well documented in the murine cerebral cortex, but the factors that drive cells into apoptosis are largely unknown. The role of neuronal activity in developmental apoptosis was studied in organotypic neocortical slice cultures of newborn mice. Multielectrode array and whole-cell patch-clamp recordings revealed spontaneous network activity characterized by synchronized burst discharges, which could be blocked by tetrodotoxin and ionotropic glutamate receptor antagonists. The identical neuropharmacological manipulations also caused a significant increase in the number of apoptotic neurons as early as 6 h after the start of dr…
Control of cortical neuronal migration by glutamate and GABA
2015
Neuronal migration in the cortex is controlled by the paracrine action of the classical neurotransmitters glutamate and GABA. Glutamate controls radial migration of pyramidal neurons by acting primarily on NMDA receptors and regulates tangential migration of inhibitory interneurons by activating non-NMDA and NMDA receptors. GABA, acting on ionotropic GABAA-rho and GABAA receptors, has a dichotomic action on radially migrating neurons by acting as a GO signal in lower layers and as a STOP signal in upper cortical plate (CP), respectively. Metabotropic GABAB receptors promote radial migration into the CP and tangential migration of interneurons. Besides GABA, the endogenous GABAergic agonist …
Platelet proteome analysis reveals an early hyperactive phenotype in SARS-CoV-2-infected humanized ACE2 mice
2021
AbstractCoronavirus disease-2019 (COVID-19) provokes a hypercoagulable state with increased incidence of thromboembolism and mortality. Platelets are major effectors of thrombosis and hemostasis. Suitable animal models are needed to better understand COVID-19-associated coagulopathy (CAC) and underlying platelet phenotypes. Here, we assessed K18-hACE2 mice undergoing a standardized SARS-CoV-2 infection protocol to study dynamic platelet responses via mass spectrometry-based proteomics. In total, we found significant changes in >1,200 proteins. Strikingly, protein alterations occurred rapidly by 2 days post-infection (dpi) and preceded outward clinical signs of severe disease. Pathway enr…
New ECCO model documents for Material Deposit and Transfer Agreements in compliance with the Nagoya Protocol
2020
The European Culture Collections Organisation presents two new model documents for Material Deposit Agreement (MDA) and Material Transfer Agreement (MTA) designed to enable microbial culture collection leaders to draft appropriate agreement documents for, respectively, deposit and supply of materials from a public collection. These tools provide guidance to collections seeking to draft an MDA and MTA, and are available in open access to be used, modified, and shared. The MDA model consists of a set of core fields typically included in a deposit form to collect relevant information to facilitate assessment of the status of the material under access and benefit sharing (ABS) legislation. It a…
Blocking NMDA-receptors in the pigeon's "prefrontal" caudal nidopallium impairs appetitive extinction learning in a sign-tracking paradigm
2015
Extinction learning provides the ability to flexibly adapt to new contingencies by learning to inhibit previously acquired associations in a context-dependent manner. The neural networks underlying extinction learning were mostly studied in rodents using fear extinction paradigms. To uncover invariant properties of the neural basis of extinction learning, we employ pigeons as a model system. Since the prefrontal cortex of mammals is a key structure for extinction learning, we assessed the role of N-methyl-D-aspartate receptors (NMDARs) in the nidopallium caudolaterale, the avian functional equivalent of mammalian prefrontal cortex. Since NMDARs in prefrontal cortex have been shown to be rel…
On extremal intersection numbers of a block design
1982
K.N. Majumdar has shown that for a 2-(v, k, @l) design D there are three numbers @a, @t, and @S such that each intersection number of D is not greater than @S and not less than max{@a, @t}. In this paper we investigate designs having one of these 'extremal' intersection numbers. Quasisymmetric designs with at least one extremal intersection number are characterized. Furthermore, we show that a smooth design D having the intersection number @S or @a>0 is isomorphic to the system of points and hyperplanes of a finite projective space. Using this theorem, we can characterize all smooth strongly resolvable designs.
A modeling study suggesting how a reduction in the context-dependent input on CA1 pyramidal neurons could generate schizophrenic behavior.
2011
The neural mechanisms underlying schizophrenic behavior are unknown and very difficult to investigate experimentally, although a few experimental and modeling studies suggested possible causes for some of the typical psychotic symptoms related to this disease. The brain region most involved in these processes seems to be the hippocampus, because of its critical role in establishing memories for objects or events in the context in which they occur. In particular, a hypofunction of the N-methyl-D-aspartate (NMDA) component of the synaptic input on the distal dendrites of CA1 pyramidal neurons has been suggested to play an important role for the emergence of schizophrenic behavior. Modeling st…
Trimdas latviešu kulturālās aktivitātes Vācijas DP nometnēs pēc Otrā pasaules kara
2019
Šajā bakalaura darbā ir pētīti vairāki vēstures zinātnē izplatīti ar kulturālajām mnemotehnikām saistīti jēdzieni un kulturālās identitātes tradīcijas veidi. Kontekstu, kurā notika pētīšana veido trimdas latviešu kulturālās aktivitātes Vācijas DP nometnēs īsi pēc Otrā pasaules kara. Darbs piedāvā ieskatu trimdas latviešu autoru rakstītu literāro darbu (lugu) izvēlē kā arī īsu pārskatu par Vācijas trimdas latviešu autoru un mākslinieku darbos manāmajām tendencēm tēlotājmākslā un teātrī dotajā vēsturiskajā posmā. Darba uzdevums ir atrast un uzsvērt Vācijas trimdas latviešu māksliniecisku aktivitāšu nozīmi Latvijas un Vācijas vēsturē un kultūrā, jo tā veido abu valstu kultūru svarīgo daļu. Pēt…