Search results for "MEF"
showing 10 items of 96 documents
Numerical simulations of turbulent flow in an electromagnetically levitated metallic droplet using k-Ω SST and Reynolds stress models
2020
International audience; Electromagnetic levitation of a metallic droplet in the microgravity conditions is modelled accounting for the droplet shape variation, its displacement and turbulent character of the flow in the system. Three different models are applied for description of turbulent flow in the droplet: k − ω SST model and two models based on Reynolds stresses (RSM), all of them resulted in a qualitatively similar flow inside a droplet. Use of RSM-based models leads to a sharper interface of a droplet in volume-of-fluid calculations compared to the k − ω SST model. Two RSM models predict value of the surface tension close to a theoretical one, yet, both fail in predicting of viscosi…
Induction mechanisms in a von Kármán swirling flow of liquid Gallium
2004
Using in situ magnetic field measurements, we study the induction mechanisms in a swirling flow of liquid Gallium generated inside a cylinder, in the gap between two coaxial rotating discs. The von Kármán flow generated in this manner has both helicity and differential rotation. Magnetic Reynolds numbers Rm up to 7 (based on the disc rim speed) are generated. We study the magnetic induction when an external field is applied successively along the axis, in the azimuthal direction or tranverse to the axis of rotation. In the first two cases, both the flow and the magnetic field are axisymmetric, and an effective mechanism of conversion from poloidal to toroidal field exists but, in agreement …
Age-dependent regulation of antioxidant genes by p38α MAPK in the liver
2018
p38α is a redox sensitive MAPK activated by pro-inflammatory cytokines and environmental, genotoxic and endoplasmic reticulum stresses. The aim of this work was to assess whether p38α controls the antioxidant defense in the liver, and if so, to elucidate the mechanism(s) involved and the age-related changes. For this purpose, we used liver-specific p38α-deficient mice at two different ages: young-mice (4 months-old) and old-mice (24 months-old). The liver of young p38α knock-out mice exhibited a decrease in GSH levels and an increase in GSSG/GSH ratio and malondialdehyde levels. However, old mice deficient in p38α had higher hepatic GSH levels and lower GSSG/GSH ratio than young p38α knock-…
Misdiagnosis of familial Mediterranean fever in patients with Anderson-Fabry disease
2013
Fabry disease (FD) is an underdiagnosed pathology due to its symptomatology that overlaps with various systemic and rheumatic disorders, including familial Mediterranean fever (FMF). We examined the Mediterranean fever (MEFV) and α-galactosidase A (GLA) genes, whose mutations are responsible for FMF and FD, respectively, in 42 unrelated patients diagnosed with FMF, which revealed significant ambiguity regarding some of the symptoms which are also present in FD. The objective of this study was to determine the spectrum of mutations present in these genes, in order to identify cases of mistaken diagnosis of FMF and/or missed diagnosis of FD. Ten out of 42 patients had one mutation in homozyg…
LA DIAGNOSTICA DELLE TUMEFAZIONI PELVICHE NELL'INFANZIE e NELL'ADOLESCENZA
1993
Le tumefazioni pelviche nell'infanzie e nell'adolescenza presentano una eterogeneità etioloogica. Gli autori analizzano gli aspetti diagnostici per imaging.
RARO CASO DI IPERPLASIA ANGIOLINFOIDE CON EOSINOFILIA DELLA REGIONE MASTOIDEA
2011
L’iperplasia angiolinfoide con eosinofilia (ALHE) è una rara malattia benigna ad eziologia poco chiara, anche se la malattia viene considerata dalla maggior parte degli autori un processo reattivo o di natura vascolare amartomatosa. Colpisce con leggera prevalenza il sesso femminile tra la III e la V decade ed è caratterizzata da lesioni papulose e nodulari con sede elettiva al capo, al collo e al condotto uditivo esterno, senza linfadenopatia e con lieve eosinofilia periferica. Dal punto di vista istologico è presente una proliferazione vascolare dermica e/o ipodermica accompagnata da un infiltrato in gran parte costituito da linfociti, istiociti ed eosinofili. Gli autori descrivono un cas…
Non c'é due senza tre: una sindrome autoinfiammatoria "complessa"
2014
Zwitterionic codeine-derived methacrylate monoliths for enantioselective capillary electrochromatography of chiral acids and chiral bases
2018
Thiol-ene click reaction of N-acetyl-L-cysteine methyl ester to codeine, followed by reaction with allyl isocyanate and hydrolysis to the corresponding zwitterionic chiral selector and its subsequent bonding to the surface of a methacrylate monolith provided a new chiral capillary column for enantiomer separation of chiral acids and chiral bases. First, the epoxy groups of a poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith were converted into amine residues, followed by reaction with allylglycidyl ether. In this way, a spacer arm was bonded to the surface before coating and cross-linking poly(3-mercaptopropyl methylsiloxane) (PMPMS) via radical addition (thiol-ene click react…
Caracterización molecular de la pérdida del poder patógeno en Agrobacterium tumefaciens
2003
Agrobacterium tumefaciens es una bacteria fitopatógena causante de tumores en el cuello y raíces de muchas especies vegetales de interés económico. En los viveros e invernaderos es donde más daños produce, al aparecer episodios epidémicos que pueden impedir la comercialización de producciones enteras, porque las plantas afectadas por esta enfermedad no pueden ser comercializadas. Los estudios epidemiológicos y de dinámica de poblaciones del patógeno son poco abundantes y han incidido en aspectos del desarrollo y mantenimiento de la enfermedad producida por la bacteria. Aunque se ha señalado el predominio de cepas no patógenas frente a patógenas en ambientes en los que las cepas productoras …
Overview of the JET results in support to ITER
2017
The 2014–2016 JET results are reviewed in the light of their significance for optimising the ITER research plan for the active and non-active operation. More than 60 h of plasma operation with ITER first wall materials successfully took place since its installation in 2011. New multi-machine scaling of the type I-ELM divertor energy flux density to ITER is supported by first principle modelling. ITER relevant disruption experiments and first principle modelling are reported with a set of three disruption mitigation valves mimicking the ITER setup. Insights of the L–H power threshold in Deuterium and Hydrogen are given, stressing the importance of the magnetic configurations and the recent m…